Antonio Pedro Camargo,Simon Roux,Frederik Schulz et al.
Antonio Pedro Camargo et al.
Identifying and characterizing mobile genetic elements in sequencing data is essential for understanding their diversity, ecology, biotechnological applications and impact on public health. Here we introduce geNomad, a classification and an...
Junyi Zou,Koushambi Mitra,Palapuravan Anees et al.
Junyi Zou et al.
Cellular sodium ion (Na+) homeostasis is integral to organism physiology. Our current understanding of Na+ homeostasis is largely limited to Na+ transport at the plasma membrane. Organelles may also contribute to Na+ homeostasis; however, t...
Detecting organelle-specific activity of potassium channels with a DNA nanodevice [0.03%]
具有DNA纳米器件的器官特异性钾通道活性检测技术
Palapuravan Anees,Anand Saminathan,Ezekiel R Rozmus et al.
Palapuravan Anees et al.
Cell surface potassium ion (K+) channels regulate nutrient transport, cell migration and intercellular communication by controlling K+ permeability and are thought to be active only at the plasma membrane. Although these channels transit th...
Detection of transcriptome-wide microRNA-target interactions in single cells with agoTRIBE [0.03%]
基于agoTRIBE在单细胞中检测转录组范围内的microRNA-靶基因相互作用
Vaishnovi Sekar,Emilio Mármol-Sánchez,Panagiotis Kalogeropoulos et al.
Vaishnovi Sekar et al.
MicroRNAs (miRNAs) exert their gene regulatory effects on numerous biological processes based on their selection of target transcripts. Current experimental methods available to identify miRNA targets are laborious and require millions of c...
Supervised discovery of interpretable gene programs from single-cell data [0.03%]
来自单细胞数据的可解释基因程序的监督发现方法
Russell Z Kunes,Thomas Walle,Max Land et al.
Russell Z Kunes et al.
Factor analysis decomposes single-cell gene expression data into a minimal set of gene programs that correspond to processes executed by cells in a sample. However, matrix factorization methods are prone to technical artifacts and poor fact...
Laura S Pfeiffer,Thorsten Stafforst
Laura S Pfeiffer
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule and serves various functions, such as evasion of the endogenous immune system and regulation of protein function. To achieve this, certain enzymes...
Michael Eisenstein
Michael Eisenstein