Soil microbiome engineering for sustainability in a changing environment [0.03%]
变化环境下的土壤微生物组工程与可持续发展
Janet K Jansson,Ryan McClure,Robert G Egbert
Janet K Jansson
Recent advances in microbial ecology and synthetic biology have the potential to mitigate damage caused by anthropogenic activities that are deleteriously impacting Earth's soil ecosystems. Here, we discuss challenges and opportunities for ...
Magdi Elsallab,Marcela V Maus
Magdi Elsallab
Chimeric antigen receptor (CAR) T cells are changing the therapeutic landscape for hematological malignancies. To date, all six CAR T cell products approved by the US Food and Drug Administration (FDA) are autologous and centrally manufactu...
Caroline Seydel
Caroline Seydel
Matthew Hutson
Matthew Hutson
Asuncion Borrero Borrego,Saar Gill
Asuncion Borrero Borrego
Petar Hristov,Ryan A Flynn
Petar Hristov
Scalable genetic screening for regulatory circuits using compressed Perturb-seq [0.03%]
利用压缩Perturb-seq进行调控电路的可扩展遗传筛选
Douglas Yao,Loic Binan,Jon Bezney et al.
Douglas Yao et al.
Pooled CRISPR screens with single-cell RNA sequencing readout (Perturb-seq) have emerged as a key technique in functional genomics, but they are limited in scale by cost and combinatorial complexity. In this study, we modified the design of...
Systematic discovery of neoepitope-HLA pairs for neoantigens shared among patients and tumor types [0.03%]
系统发现患者和肿瘤类型中共有的新抗原neoepitope-HLA配对
Hem R Gurung,Amy J Heidersbach,Martine Darwish et al.
Hem R Gurung et al.
The broad application of precision cancer immunotherapies is limited by the number of validated neoepitopes that are common among patients or tumor types. To expand the known repertoire of shared neoantigen-human leukocyte antigen (HLA) com...
Author Correction: Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning [0.03%]
作者更正：使用CRISPRi筛选、目标库分析和机器学习开发的高效C•G到G•C碱基编辑器
Luke W Koblan,Mandana Arbab,Max W Shen et al.
Luke W Koblan et al.
Published Erratum
Nature biotechnology. 2023 Nov;41(11):1655. DOI:10.1038/s41587-023-02028-8 2023