Control of mammalian gene expression by modulation of polyA signal cleavage at 5' UTR [0.03%]
通过调节5'UTR的多聚A信号切割来控制哺乳动物基因表达
Liming Luo,Jocelyn Duen-Ya Jea,Yan Wang et al.
Liming Luo et al.
The ability to control gene expression in mammalian cells is crucial for safe and efficacious gene therapies and for elucidating gene functions. Current gene regulation systems have limitations such as harmful immune responses or low effici...
Detection of mosaic and population-level structural variants with Sniffles2 [0.03%]
Sniffles2对马赛克变异和群体水平结构变异的检测
Moritz Smolka,Luis F Paulin,Christopher M Grochowski et al.
Moritz Smolka et al.
Calling structural variations (SVs) is technically challenging, but using long reads remains the most accurate way to identify complex genomic alterations. Here we present Sniffles2, which improves over current methods by implementing a rep...
Aji Istadi,Sean Porazinski,Marina Pajic
Aji Istadi
Anne Doerr
Anne Doerr
Anahita Bishop
Anahita Bishop
Kenna Hughes-Castleberry
Kenna Hughes-Castleberry