A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation [0.03%]
构建一个酰基转移酶的化学遗传学体系来分析ZDHHC特异性的S-酰化蛋白地图
Cory A Ocasio,Marc P Baggelaar,James Sipthorp et al.
Cory A Ocasio et al.
The 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S-acyltransferases catalyze long-chain S-acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in...
Cell and gene therapy approvals in Japan and the need for international harmonization [0.03%]
日本的细胞和基因治疗审批及国际协调的需求
Teruyo Arato,Kaori Nomura
Teruyo Arato
It takes two to think [0.03%]
两个人一起思考效果好
Itai Yanai,Martin J Lercher
Itai Yanai
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases [0.03%]
表达IL-10的CAR-T细胞可抵抗功能障碍并持久清除实体瘤和转移瘤
Yang Zhao,Jiangqing Chen,Massimo Andreatta et al.
Yang Zhao et al.
The success of chimeric antigen receptor (CAR) T cell therapy in treating several hematopoietic malignancies has been difficult to replicate in solid tumors, in part because of T cell exhaustion and eventually dysfunction. To counter T cell...
Characterization and visualization of tandem repeats at genome scale [0.03%]
基因组尺度上串联重复的特征提取及可视化技术研究
Egor Dolzhenko,Adam English,Harriet Dashnow et al.
Egor Dolzhenko et al.
Tandem repeat (TR) variation is associated with gene expression changes and numerous rare monogenic diseases. Although long-read sequencing provides accurate full-length sequences and methylation of TRs, there is still a need for computatio...
Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells [0.03%]
基于糖基化酶的碱基编辑器可实现哺乳动物细胞中高效的T-to-G 和C-to-G 编辑
Lijun Ye,Dongdong Zhao,Ju Li et al.
Lijun Ye et al.
Base editors show promise for treating human genetic diseases, but most current systems use deaminases, which cause off-target effects and are limited in editing type. In this study, we constructed deaminase-free base editors for cytosine (...
Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons [0.03%]
组合小分子药物治疗加速人多能干细胞衍生神经元的成熟过程
Emiliano Hergenreder,Andrew P Minotti,Yana Zorina et al.
Emiliano Hergenreder et al.
The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the protracted timing of human brain development, extending over months to years for reaching adult-like function. Prolonged in vitro maturation presents a major ch...