Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets [0.03%]
基于成像的空间转录组学数据集的评估和可重复性标准化指标
Jasmine T Plummer,Felipe Segato Dezem,David P Cook et al.
Jasmine T Plummer et al.
Spatial transcriptomics lacks standardized metrics for evaluating imaging-based in situ hybridization technologies across sites. In this study, we generated the Spatial Touchstone (ST) dataset from six tissue types across several global sit...
Kasey S Love,Kate E Galloway
Kasey S Love
Gabriele et al. reply [0.03%]
盖布拉里等人回复
Sarah M E Gabriele,Matthew J Martin,Aaron S Kesselheim et al.
Sarah M E Gabriele et al.
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia [0.03%]
抗炎脂质递送肽体mRNA治疗多重耐药细菌肺炎
Yonger Xue,Xucheng Hou,Siyu Wang et al.
Yonger Xue et al.
The efficacy of antimicrobial peptides (AMPs) is limited by challenges of delivery and potency. We enhance AMP performance in the lung by converting AMPs to a peptibody format that fuses AMPs with fragment crystallizable domains to activate...
All-optical visualization of specific molecules in the ultrastructural context of brain tissue [0.03%]
全光学脑组织中超结构性背景下的特定分子可视化技术
Ons M&#x;Saad,Allison Cairns,Jonathan Gulcicek et al.
Ons M&#x;Saad et al.
Understanding the molecular anatomy and neural connectivity of the brain requires imaging technologies that can map the three-dimensional nanoscale distribution of specific proteins in the context of brain ultrastructure. Light and electron...
Sevahn K Vorperian,Lucas M Dennis,Anna Hupalowska et al.
Sevahn K Vorperian et al.
Cell-free nucleic acid (cfNA) liquid biopsy offers a versatile, noninvasive alternative to needle biopsy procedures for the diagnosis or surveillance of a broad range of diseases and physiological conditions. Although these noninvasive mole...
Simon Alamos,Lucas Waldburger,Amanda Dee et al.
Simon Alamos et al.
Transcriptional regulators play key roles in plant growth, development and environmental responses; however, understanding how their regulatory activity is encoded at the protein level has been hindered by a lack of multiplexed large-scale ...
Author Correction: Binary vector copy number engineering improves Agrobacterium-mediated transformation [0.03%]
作者更正：二进制载体拷贝数工程可改进农杆菌介导的转化
Matthew J Szarzanowicz,Lucas M Waldburger,Michael Busche et al.
Matthew J Szarzanowicz et al.
Published Erratum
Nature biotechnology. 2025 Nov 24. DOI:10.1038/s41587-025-02959-4 2025
Longfei Jia,Tan-Trung Nguyen,Saori Uematsu et al.
Longfei Jia et al.
Several approaches exist to silence genes, but few tools are available to activate individual mRNAs for translation inside cells. Guiding ribosomes to specific start codons without altering the original sequence remains a formidable task. H...