Now with oligos: antibody-oligonucleotide conjugates are the new drug modality to watch [0.03%]
新型抗体药物偶联物：抗体—寡核苷酸缀合物
Cormac Sheridan
Cormac Sheridan
Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma [0.03%]
工程化双特异性活化T细胞的细胞外囊泡以靶向免疫检查点抑制剂耐药的转移性黑色素瘤
Shuo Liu,Mengrui Liu,Zhenzhen Wang et al.
Shuo Liu et al.
Cancer immunotherapy with immune checkpoint inhibitors (ICIs) is often limited by an immunosuppressive tumor microenvironment (TME). Simultaneous targeting of the TME and immune checkpoints is a promising approach to address this limitation...
CRISPR-Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis [0.03%]
基于CRISPR-Cas3的小鼠转甲状腺素淀粉样变病基因编辑模型中的靶向删除疗法
Saeko Ishida,Yusuke Sato,Keisuke Chosa et al.
Saeko Ishida et al.
CRISPR-Cas3 represents a mechanistically distinct genome-editing system compared to Cas9 that generates long-range deletions rather than small indels, thereby reducing the risk of residual protein function from in-frame mutations. Here we e...
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM [0.03%]
基于空间转录组数据绘制异构体和调控机制的研究——利用SPLISOM方法
Jiayu Su,Yiming Qu,Megan Schertzer et al.
Jiayu Su et al.
Transcript diversity including splicing and alternative 3' end usage is crucial for cellular identity and adaptation, yet its spatial coordination remains poorly understood. Here we present SPLISOSM (spatial isoform statistical modeling), a...
Revealing a coherent cell-state landscape across single-cell datasets with CONCORD [0.03%]
使用CONCORD揭示单细胞数据集中一致的细胞状态景观
Qin Zhu,Zuzhi Jiang,Binyamin Zuckerman et al.
Qin Zhu et al.
Revealing the underlying cell-state landscape from single-cell data requires overcoming the critical obstacles of batch integration, denoising and dimensionality reduction. Here we present CONCORD, a unified framework that simultaneously ad...
Integrated experimental and AI innovations for RNA structure determination [0.03%]
集成实验与人工智能创新的RNA结构测定法
Wenkai Wang,Baoquan Su,Zhenling Peng et al.
Wenkai Wang et al.
RNAs act as crucial 'social' mediators within the cell, orchestrating a wide array of biological processes. Their functionality hinges on their complex three-dimensional structures, which dictate stability, binding specificity and molecular...
Anders Kämpe,Oda Blomqvist Picard,Jesper Eisfeldt et al.
Anders Kämpe et al.
Predicting small molecule-RNA interactions without RNA tertiary structures [0.03%]
无需RNA三级结构的小分子-RNA互作预测模型
Yuhan Fei,Pengfei Wang,Jiasheng Zhang et al.
Yuhan Fei et al.
Small molecules can bind RNAs to regulate their fate and functions, providing promising opportunities for treating human diseases. However, current tools for predicting small molecule-RNA interactions (SRIs) require prior knowledge of RNA t...