A trimodal protein language model enables advanced protein searches [0.03%]
一种三模式蛋白质语言模型能够实现先进的蛋白质搜索功能
Jin Su,Yan He,Shiyang You et al.
Jin Su et al.
ProTrek unifies protein sequence, structure and natural language function in a trimodal language model through contrastive learning, enabling comprehensive searches between any two modalities, including within modality. ProTrek surpasses cu...
Jin Su,Yan He,Shiyang You et al.
Jin Su et al.
ProTrek unifies protein sequence, structure and natural language function in a trimodal language model through contrastive learning, enabling comprehensive searches between any two modalities, including within modality. ProTrek surpasses cu...
Detecting and quantifying circular RNAs in terabyte-scale RNA-seq datasets with CIRI3 [0.03%]
利用CIRI3检测和量化太字节规模RNA测序数据集中的环状RNA
Xin Zheng,Jinyang Zhang,Lipu Song et al.
Xin Zheng et al.
To address recent challenges in circular RNA (circRNA) analysis, we present CIRI3, a tool for circRNA detection and quantification in terabyte-scale RNA-sequencing datasets. Using dynamic multithreaded task partitioning and a blocking searc...
Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates [0.03%]
优化设计表观遗传调控序列以实现非人灵长类目标基因持久沉默的效果
Shaoshuai Mao,Wenbo Peng,Zhengyan Feng et al.
Shaoshuai Mao et al.
Epigenetic editing is a promising strategy for modifying gene expression while avoiding the permanent alterations and potential genotoxicity of genome-editing technologies. Here we designed optimized epigenetic regulators (EpiRegs) by testi...
Scaling DNA synthesis with a microchip-based massively parallel synthesis system [0.03%]
基于微芯片的大规模并行合成系统的DNA合成.scalingDNA合成
Xiandi Zhang,Xiang&#x;er Jiang,Yun Wang et al.
Xiandi Zhang et al.
Current high-throughput DNA synthesis technologies use intricate chip and microfluidic systems to produce large-scale synthetic oligonucleotides but with low concentration and limited compatibility for long DNA assembly. Here we report a ma...
Xi Chen,Zheng Guo,Xinyi Tong et al.
Xi Chen et al.
Germline-competent embryonic stem (ES) cells have been successfully derived from mice and rats, but not from other species. Here we report the development of culture conditions for deriving ES cells from chickens and seven other avian speci...
Yangqing Lu,Long Xie
Yangqing Lu
Charles Schmidt
Charles Schmidt
From frameworks to finance: how sharing benefits from the use of digital sequence information can evolve to contribute to biodiversity conservation [0.03%]
从框架到资金：如何共享数字序列信息的利益以发展并有助于生物多样性保护
Charlotte Blom,Marcel Jaspars,Jasmina Muminovic Rilak et al.
Charlotte Blom et al.