Engineered pattern recognition receptors enhance broad-spectrum plant resistance [0.03%]
工程型模式识别受体可增强广谱植物抗性
Yuankun Yang,Christina E Steidele,Xianlong Huang et al.
Yuankun Yang et al.
Conventional plant resistance breeding has primarily focused on intracellular immune receptors, while cell-surface pattern recognition receptors (PRRs) have been underexplored because of their comparatively modest contributions to resistanc...
Programmable promoter editing for precise control of transgene expression [0.03%]
可编程启动子编辑实现转基因精确表达调控
Sneha R Kabaria,Yunbeen Bae,Mary E Ehmann et al.
Sneha R Kabaria et al.
Subtle changes in gene expression direct cells to distinct cellular states. Identifying and controlling dose-dependent transgenes require tools for precisely titrating expression. Here, we develop a highly modular, extensible framework call...
Tassilo L A Wachsmann,Lei S Qi
Tassilo L A Wachsmann
Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells [0.03%]
公原核胚胎干细胞产生修饰牛和羊
Lei Yang,Anqi Di,Lishuang Song et al.
Lei Yang et al.
In rodents, injection of haploid androgenetic embryonic stem cells (haES cells) into intact oocytes enables full-term development of offspring. The value of this method in research and genome engineering has not been replicated in ruminants...
Björn Oback
Björn Oback
Cholpon Tilegenova,Tun Liu,Qian Zhao et al.
Cholpon Tilegenova et al.
Bispecific antibodies (bsAbs) can enable therapeutic mechanisms, such as dual antigen targeting or receptor agonism, that are impossible using monoclonal antibodies. BsAbs with IgG-like format (bsIgG) are comprised of two unique heavy chain...
Discovery and protein language model-guided design of hyperactive transposases [0.03%]
高活性转座酶的发现和蛋白质语言模型引导的设计
Dimitrije Ivančić,Alejandro Agudelo,Jonathan Lindstrom-Vautrin et al.
Dimitrije Ivančić et al.
The diversity and biochemical potential of the PiggyBac transposase gene insertion system remains largely unexplored. Using a eukaryotic transposon mining pipeline, we expand the explored diversity by two orders of magnitude and experimenta...
Discovery and protein language model-guided design of hyperactive transposases [0.03%]
超强转座酶的发现与蛋白质语言模型引导设计
Dimitrije Ivančić,Alejandro Agudelo,Jonathan Lindstrom-Vautrin et al.
Dimitrije Ivančić et al.
The diversity and biochemical potential of the PiggyBac transposase gene insertion system remains largely unexplored. Using a eukaryotic transposon mining pipeline, we expand the explored diversity by two orders of magnitude and experimenta...