Author Correction: Folding-mediated secretion of pure bispecific antibodies [0.03%]
作者更正：介导的纯双特异性抗体分泌折叠
Cholpon Tilegenova,Tun Liu,Qian Zhao et al.
Cholpon Tilegenova et al.
Published Erratum
Nature biotechnology. 2025 Oct 28. DOI:10.1038/s41587-025-02918-z 2025
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels [0.03%]
一种单链整合素活化抗体衍生物可促进基底膜和胶原蛋白水凝胶中类器官的生长
Wim B M de Lau,Joost J A P M Wijnakker,Gijs J F van Son et al.
Wim B M de Lau et al.
Current methods of culturing human epithelial organoids from adult stem cells may not be compatible with clinical applications as they rely on xenogeneic, chemically undefined or non-standardized components such as the basement membrane ext...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions [0.03%]
选择性RNA聚集在生物分子凝聚体内调控细胞命运转变
Patrizia Pessina,Mika Nevo,Junchao Shi et al.
Patrizia Pessina et al.
Controlling stem cell differentiation is a longstanding goal in biomedical research. Here we explore how cell fate is influenced by RNA condensates, specifically P-bodies, which modulate gene expression posttranscriptionally. We profiled th...
Yumeng Zhang,Jiangning Song,Cesar de la Fuente-Nunez
Yumeng Zhang
Gabriele Scalia,Steven T Rutherford,Ziqing Lu et al.
Gabriele Scalia et al.
The increase in multidrug-resistant bacteria underscores an urgent need for additional antibiotics. Here, we integrate small-molecule high-throughput screening with a deep-learning-based virtual screening approach to uncover new antibacteri...
Democratizing protein language model training, sharing and collaboration [0.03%]
蛋白质语言模型的民主化训练、分享与合作
Jin Su,Zhikai Li,Tianli Tao et al.
Jin Su et al.
Training and deploying large-scale protein language models typically requires deep machine learning expertise-a barrier for researchers outside this field. SaprotHub overcomes this challenge by offering an intuitive platform that facilitate...
Benjamin B Larsen,Ofer Kimchi,Owen R S Dunkley et al.
Benjamin B Larsen et al.
Cas13 is activated by the hybridization of a CRISPR RNA to a complementary single-stranded RNA protospacer in a target RNA. While Cas13 is not activated by double-stranded RNA in vitro, it robustly targets RNA in cellular environments where...
Elucidating lipid nanoparticle properties and structure through biophysical analyses [0.03%]
通过生物物理分析阐明脂质纳米颗粒的性质和结构
Marshall S Padilla,Sarah J Shepherd,Andrew R Hanna et al.
Marshall S Padilla et al.
Designing lipid nanoparticle (LNP) delivery systems with specific targeting, potency and minimal side effects is crucial for their clinical use. However, traditional characterization methods, such as dynamic light scattering, cannot accurat...