A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording [0.03%]
哺乳动物基因组工程和分子记录的启动子和gRNA支架清单
Troy A McDiarmid,Megan L Taylor,Wei Chen et al.
Troy A McDiarmid et al.
A standardized 'parts list' of sequences for genetic engineering of microbes has been indispensable to progress in synthetic biology, but few analogous parts exist for mammalian systems. Here we design libraries of extant, ancestral, mutage...
Multimodal learning enables chat-based exploration of single-cell data [0.03%]
多模态学习使基于聊天的单细胞数据分析成为可能
Moritz Schaefer,Peter Peneder,Daniel Malzl et al.
Moritz Schaefer et al.
Single-cell sequencing characterizes biological samples at unprecedented scale and detail, but data interpretation remains challenging. Here, we present CellWhisperer, an artificial intelligence (AI) model and software tool for chat-based i...
Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models [0.03%]
超声清除颅内血肿碎片可减轻出血性卒中模型中的炎症并改善预后
Matine M Azadian,Sepideh Kiani Shabestari,Arjun Rajan et al.
Matine M Azadian et al.
Impaired clearance of neurotoxic debris in the brain exacerbates neurologic disease and presents a promising therapeutic target. Pharmacologic therapies can enhance meningeal lymphatic clearance in preclinical models but may be limited by s...
Zachary Papadopoulos,Max A Tischfield
Zachary Papadopoulos
Publisher Correction: Deep-learning-based virtual screening of antibacterial compounds [0.03%]
出版更正：基于深度学习的抗菌化合物虚拟筛选
Gabriele Scalia,Steven T Rutherford,Ziqing Lu et al.
Gabriele Scalia et al.
Published Erratum
Nature biotechnology. 2025 Nov 7. DOI:10.1038/s41587-025-02941-0 2025
Soo-Jin Jung,Jenny J Seo,Sunghan Lee et al.
Soo-Jin Jung et al.
The limited stability of mRNA in vivo remains a major challenge for vaccines and therapeutics. While alternative RNA formats such as circular RNA or self-amplifying RNA offer greater durability, these modalities often suffer from low transl...
Site-specific DNA insertion into the human genome with engineered recombinases [0.03%]
重组酶定点整合人类基因组中的DNA
Alison Fanton,Liam J Bartie,Juliana Q Martins et al.
Alison Fanton et al.
Insertions of large DNA sequences into the genome are broadly enabling for research and therapeutic applications. Large serine recombinases (LSRs) can mediate direct, site-specific genomic integration of multi-kilobase DNA sequences without...