A chromosomal mutation is superior to a plasmid-encoded mutation for plasmid fitness cost compensation [0.03%]
染色体突变优于质粒编码突变以补偿质粒适应度消耗
Rosanna C T Wright,A Jamie Wood,Michael J Bottery et al.
Rosanna C T Wright et al.
Plasmids are important vectors of horizontal gene transfer in microbial communities but can impose a burden on the bacteria that carry them. Such plasmid fitness costs are thought to arise principally from conflicts between chromosomal- and...
Intracellular polarization of RNAs and proteins in the human small intestinal epithelium [0.03%]
人小肠上皮细胞内RNA和蛋白质的极性分布
Roy Novoselsky,Yotam Harnik,Oran Yakubovsky et al.
Roy Novoselsky et al.
The intestinal epithelium is a polarized monolayer of cells, with an apical side facing the lumen and a basal side facing the blood stream. In mice, both proteins and mRNAs have been shown to exhibit global basal-apical polarization; howeve...
Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia [0.03%]
黑皮质素 1 受体通过与原纤毛中的 BBSome 相互作用介导黑色素生成
Xiaoyu Tian,Hanyu Wang,Song Liu et al.
Xiaoyu Tian et al.
Production of melanin pigments is a protective mechanism of the skin against ultraviolet (UV)-induced damage and carcinogenesis. However, the molecular basis for melanogenesis is still poorly understood. Herein, we demonstrate a critical in...
The thalamus encodes and updates context representations during hierarchical cognitive control [0.03%]
丘脑在层级认知控制过程中编码和更新上下文表征
Xitong Chen,Stephanie C Leach,Juniper Hollis et al.
Xitong Chen et al.
Cognitive flexibility relies on hierarchically structured task representations that organize task contexts, relevant environmental features, and subordinate decisions. Despite ongoing interest in the human thalamus, its role in cognitive co...
Axons compensate for biophysical constraints of variable size to uniformize their action potentials [0.03%]
轴突通过调节大小来补偿其生物物理限制以统一动作电位
János Brunner,Antónia Arszovszki,Gergely Tarcsay et al.
János Brunner et al.
Active conductances tune the kinetics of axonal action potentials (APs) to support specialized functions of neuron types. However, the temporal characteristics of voltage signals strongly depend on the size of neuronal structures, as capaci...
Meta-analysis of single-cell RNA sequencing co-expression in human neural organoids reveals their high variability in recapitulating primary tissue [0.03%]
人源神经类器官单细胞RNA测序共表达的meta分析揭示其再现原始组织的高度变异性
Jonathan M Werner,Jesse Gillis
Jonathan M Werner
Human neural organoids offer an exciting opportunity for studying inaccessible human-specific brain development; however, it remains unclear how precisely organoids recapitulate fetal/primary tissue biology. We characterize field-wide repli...
Meta-Analysis
PLoS biology. 2024 Dec 2;22(12):e3002912. DOI:10.1371/journal.pbio.3002912 2024
Temperature cues are integrated in a flexible circadian neuropeptidergic feedback circuit to remodel sleep-wake patterns in flies [0.03%]
温度线索通过灵活的昼夜神经肽反馈回路整合来重塑果蝇的睡眠-觉醒模式
Xin Yuan,Hailiang Li,Fang Guo
Xin Yuan
Organisms detect temperature signals through peripheral neurons, which relay them to central circadian networks to drive adaptive behaviors. Despite recent advances in Drosophila research, how circadian circuits integrate temperature cues w...
Elevated vesicular Zn2+ in dorsal root ganglion neurons expressing the transporter TMEM163 causes age-associated itchy skin in mice [0.03%]
小鼠背根神经节神经元中转运蛋白TMEM163引起的囊泡锌离子升高导致年龄相关的皮肤瘙痒感
Fang Tong,Shuai Liu,Chen Zhang et al.
Fang Tong et al.
The prevalent itching condition associated with aging, historically referred to as senile pruritus, diminishes quality of life. Despite its impact, effective treatments remain elusive, largely due to an incomplete understanding of its patho...
Renny Ng,Chih-Ying Su
Renny Ng
Intraflagellar transport (IFT) is essential for both ciliary structure and function. A new study in PLOS Biology reveals how IFT-mediated trafficking and ciliary morphology differentially influence chemosensory responses between neuronal ty...
A strategy to design protein-based antagonists against type I cytokine receptors [0.03%]
一类细胞因子受体的蛋白质拮抗剂的设计策略
Timo Ullrich,Olga Klimenkova,Christoph Pollmann et al.
Timo Ullrich et al.
Excessive cytokine signaling resulting from dysregulation of a cytokine or its receptor can be a main driver of cancer, autoimmune, or hematopoietic disorders. Here, we leverage protein design to create tailored cytokine receptor blockers w...