Comprehensive blueprint of Salmonella genomic plasticity identifies hotspots for pathogenicity genes [0.03%]
大肠杆菌基因组可塑性的全局图谱鉴定出致病基因的热点区域
Simran Krishnakant Kushwaha,Yi Wu,Hugo Leonardo Avila et al.
Simran Krishnakant Kushwaha et al.
Understanding the dynamic evolution of Salmonella is vital for effective bacterial infection management. This study explores the role of the flexible genome, organised in regions of genomic plasticity (RGP), in shaping the pathogenicity of ...
Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery [0.03%]
伤寒沙门氏菌利用宿主多胺装配第三类分泌装置
Tsuyoshi Miki,Takeshi Uemura,Miki Kinoshita et al.
Tsuyoshi Miki et al.
Bacterial pathogens utilize the factors of their hosts to infect them, but which factors they exploit remain poorly defined. Here, we show that a pathogenic Salmonella enterica serovar Typhimurium (STm) exploits host polyamines for the func...
Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling [0.03%]
胆固醇依赖的胆囊收缩素受体构象动态变化影响配体结合和G蛋白偶联
Kaleeckal G Harikumar,Peishen Zhao,Brian P Cary et al.
Kaleeckal G Harikumar et al.
Development of optimal therapeutics for disease states that can be associated with increased membrane cholesterol requires better molecular understanding of lipid modulation of the drug target. Type 1 cholecystokinin receptor (CCK1R) agonis...
Hyphae of the fungus Aspergillus nidulans demonstrate chemotropism to nutrients and pH [0.03%]
营养物质和pH值诱导曲霉菌丝趋化运动
Riho Yamamoto,Hinata Miki,Ayaka Itani et al.
Riho Yamamoto et al.
The importance of fungi in ecological systems and pathogenicity hinges on their ability to search for nutrients, substrates, and hosts. Despite this, the question of whether fungal hyphae exhibit chemotropism toward them remains largely unr...
Chengxin Zhang,Lydia Freddolino
Chengxin Zhang
Despite the increasing number of 3D RNA structures in the Protein Data Bank, the majority of experimental RNA structures lack thorough functional annotations. As the significance of the functional roles played by noncoding RNAs becomes incr...
Correction: GABAergic regulation of striatal spiny projection neurons depends upon their activity state [0.03%]
更正：GABA能调节依赖于其活性状态的纹状体棘细胞神经元
Michelle Day,Marziyeh Belal,William C Surmeier et al.
Michelle Day et al.
[This corrects the article DOI: 10.1371/journal.pbio.3002483.]. Copyright: © 2024 Day et al. This is an open access article distributed under the terms ...
Published Erratum
PLoS biology. 2024 Jul 26;22(7):e3002752. DOI:10.1371/journal.pbio.3002752 2024
Alternative TSS use is widespread in Cryptococcus fungi in response to environmental cues and regulated genome-wide by the transcription factor Tur1 [0.03%]
转录因子Tur1调控的一种广泛存在于曲霉属真菌中的替代TSS使用模式对环境刺激有响应作用
Thi Tuong Vi Dang,Corinne Maufrais,Jessie Colin et al.
Thi Tuong Vi Dang et al.
Alternative transcription start site (TSS) usage regulation has been identified as a major means of gene expression regulation in metazoans. However, in fungi, its impact remains elusive as its study has thus far been restricted to model ye...
Prophage induction can facilitate the in vitro dispersal of multicellular Streptomyces structures [0.03%]
诱导前噬菌体可促进多细胞放线菌结构的体外分散
Hoda Jaffal,Mounia Kortebi,Pauline Misson et al.
Hoda Jaffal et al.
Streptomyces are renowned for their prolific production of specialized metabolites with applications in medicine and agriculture. These multicellular bacteria present a sophisticated developmental cycle and play a key role in soil ecology. ...
Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway [0.03%]
Wnt信号通过调节EGF途径调控果蝇翼 imaginal disc的DNA损伤修复反应
Ben Ewen-Campen,Norbert Perrimon
Ben Ewen-Campen
Despite the deep conservation of the DNA damage response (DDR) pathway, cells in different contexts vary widely in their susceptibility to DNA damage and their propensity to undergo apoptosis as a result of genomic lesions. One of the cell ...
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease [0.03%]
选择性抑制星形胶质细胞和少突胶质细胞来源的淀粉样蛋白β缓解阿尔茨海默病小鼠模型的神经元功能障碍
Rikesh M Rajani,Robert Ellingford,Mariam Hellmuth et al.
Rikesh M Rajani et al.
Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's disease (AD), but the underlying assumption that neurons are the main source of pathogenic Aβ is untested. Here, we challenge this prevailing belief by ...