The ability of pentose pathways to form all essential metabolites provides clues to the origins of metabolism [0.03%]
戊糖途径能够形成所有必要的代谢物这一能力为揭示新陈代谢的起源提供了线索
Steffen N Lindner,Markus Ralser
Steffen N Lindner
The structure of the early metabolic network is unknown. Here, we report that when considered together, pentose utilization pathways form all life-essential precursors. We speculate that the chemistry preserved in pentose metabolism could t...
Cortical direction selectivity increases from the input to the output layers of visual cortex [0.03%]
视觉皮层的输入和输出层之间的方向选择性增加
Weifeng Dai,Tian Wang,Yang Li et al.
Weifeng Dai et al.
Sensitivity to motion direction is a feature of visual neurons that is essential for motion perception. Recent studies have suggested that direction selectivity is re-established at multiple stages throughout the visual hierarchy, which con...
FLCCR is a fluorescent reporter system that quantifies the duration of different cell cycle phases at the single-cell level in fission yeast [0.03%]
一种能够在裂殖酵母中以单细胞分辨率定量不同细胞周期时长的荧光报告系统
Guillem Murciano-Julià,Marina Francos-Cárdenas,Clàudia Salat-Canela et al.
Guillem Murciano-Julià et al.
Fission yeast is an excellent model system that has been widely used to study the mechanism that control cell cycle progression. However, there is a lack of tools that allow to measure with high precision the duration of the different phase...
Dynamic collateral sensitivity profiles highlight opportunities and challenges for optimizing antibiotic treatments [0.03%]
动态抵押敏感性谱图揭示了优化抗生素治疗的机遇与挑战
Jeff Maltas,Anh Huynh,Kevin B Wood
Jeff Maltas
As failure rates for traditional antimicrobial therapies escalate, recent focus has shifted to evolution-based therapies to slow resistance. Collateral sensitivity-the increased susceptibility to one drug associated with evolved resistance ...
Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron [0.03%]
功能性分析保守的C. elegans bHLH家族成员发现寿命由一种肽能神经元控制
G Robert Aguilar,Berta Vidal,Hongzhu Ji et al.
G Robert Aguilar et al.
Throughout the animal kingdom, several members of the basic helix-loop-helix (bHLH) family act as proneural genes during early steps of nervous system development. Roles of bHLH genes in specifying terminal differentiation of postmitotic ne...
Endocytosis of Wnt ligands from surrounding epithelial cells positions microtubule nucleation sites at dendrite branch points [0.03%]
来自周围上皮细胞的Wnt配体内吞定位微管成核位点以进行树突分支
Pankajam Thyagarajan,Hannah S Mirshahi,Gregory O Kothe et al.
Pankajam Thyagarajan et al.
Microtubule nucleation is important for microtubule organization in dendrites and for neuronal injury responses. The core nucleation protein, γTubulin (γTub), is localized to dendrite branch points in Drosophila sensory neurons by Wnt rec...
SUMO-mediated regulation of H3K4me3 reader SET-26 controls germline development in C. elegans [0.03%]
C.elegans中的SUMO介导的H3K4me3读取器SET-26调控生殖细胞发育
Cátia A Carvalho,Ulrike Bening Abu-Shach,Asha Raju et al.
Cátia A Carvalho et al.
Sumoylation is a posttranslational modification essential for multiple cellular functions in eukaryotes. ULP-2 is a conserved SUMO protease required for embryonic development in Caenorhabditis elegans. Here, we revealed that ULP-2 controls ...
PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish [0.03%]
PRDM9驱动鲑鱼属鱼类重组热点位置的选择及其快速进化
Marie Raynaud,Paola Sanna,Julien Joseph et al.
Marie Raynaud et al.
In many eukaryotes, meiotic recombination occurs preferentially at discrete sites, called recombination hotspots. In various lineages, recombination hotspots are located in regions with promoter-like features and are evolutionarily stable. ...
Terminology in ecology and evolutionary biology disproportionately harms marginalized groups [0.03%]
生态学和进化生物学中的术语对边缘化群体的伤害不成比例
Mallory M Rice,Shersingh Joseph Tumber-Dávila,Marcella D Baiz et al.
Mallory M Rice et al.
The discipline of ecology and evolutionary biology (EEB) has long grappled with issues of inclusivity and representation, particularly for individuals with systematically excluded and marginalized backgrounds or identities. For example, sig...
Cell wall components of gut commensal bacteria stimulate peritrophic matrix formation in malaria vector mosquitoes through activation of the IMD pathway [0.03%]
肠道共生菌的细胞壁成分通过激活IMD途径刺激疟疾媒介蚊虫的中肠黏液形成
Xiumei Song,Han Zhou,Jingwen Wang
Xiumei Song
The peritrophic matrix (PM) acts as a physical barrier that influences the vector competence of mosquitoes. We have previously shown that gut microbiota promotes PM formation in Anopheles stephensi, although the underlying mechanisms remain...