Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour [0.03%]
室旁丘脑神经元应激后持续过度放电对于应激行为异常至关重要
Anna Jász,László Biró,Zsolt Buday et al.
Anna Jász et al.
A single exposure to a stressful event can result in enduring changes in behaviour. Long-term modifications in neuronal networks induced by stress are well explored but the initial steps leading to these alterations remain incompletely unde...
Cas W Coopmans,Helen de Hoop,Filiz Tezcan et al.
Cas W Coopmans et al.
Studies of perception have long shown that the brain adds information to its sensory analysis of the physical environment. A touchstone example for humans is language use: to comprehend a physical signal like speech, the brain must add ling...
Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution [0.03%]
纵向高时间分辨率探究年轻女性生殖器人乳头瘤病毒感染及免疫动力学
Nicolas Tessandier,Baptiste Elie,Vanina Boué et al.
Nicolas Tessandier et al.
Human papillomavirus (HPV) infections drive one in 20 new cancer cases, exerting a particularly high burden on women. Most anogenital HPV infections are cleared in less than two years, but the underlying mechanisms that favour persistence i...
Observational Study
PLoS biology. 2025 Jan 21;23(1):e3002949. DOI:10.1371/journal.pbio.3002949 2025
Spontaneous slow cortical potentials and brain oscillations independently influence conscious visual perception [0.03%]
自发性的慢皮层电位和脑震荡独立影响视觉感知-consciousness
Lua Koenig,Biyu J He
Lua Koenig
Perceptual awareness results from an intricate interaction between external sensory input and the brain's spontaneous activity. Pre-stimulus ongoing activity influencing conscious perception includes both brain oscillations in the alpha (7 ...
Multi-tissue characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression [0.03%]
多组织表征果蝇构成性异染色质蛋白质组揭示了卫星DNA组织与转座子抑制之间的联系
Ankita Chavan,Lena Skrutl,Federico Uliana et al.
Ankita Chavan et al.
Noncoding satellite DNA repeats are abundant at the pericentromeric heterochromatin of eukaryotic chromosomes. During interphase, sequence-specific DNA-binding proteins cluster these repeats from multiple chromosomes into nuclear foci known...
Jaline Gerardin,Melissa A Penny
Jaline Gerardin
When models are used to inform decision-making, both their strengths and limitations must be considered. Using malaria as an example, we explain how and why models are limited and offer guidance for ensuring a model is well-suited for its i...
Daniel B Sloan,Mark D Stenglein
Daniel B Sloan
"Big data" generated from outsourced or centralized facilities often lacks methodological information. Here, we outline how and why researchers, service providers, and other parties should report on methodology and sample metadata to improv...
Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict [0.03%]
背侧海马在接近回避冲突中表征要接近和回避的位置
Olivia L Calvin,Matthew T Erickson,Cody J Walters et al.
Olivia L Calvin et al.
Worrying about perceived threats is a hallmark of multiple psychological disorders including anxiety. This concern about future events is particularly important when an individual is faced with an approach-avoidance conflict. Potential goal...
Discovery of non-retinoid compounds that suppress the pathogenic effects of misfolded rhodopsin in a mouse model of retinitis pigmentosa [0.03%]
视杆细胞错折叠蛋白诱发色素性视网膜炎的小鼠模型中发现的非维甲酸化合物具有抑制病理性效应的作用
Joseph T Ortega,Jacklyn M Gallagher,Andrew G McKee et al.
Joseph T Ortega et al.
Pathogenic mutations that cause rhodopsin misfolding lead to a spectrum of currently untreatable blinding diseases collectively termed retinitis pigmentosa. Small molecules to correct rhodopsin misfolding are therefore urgently needed. In t...
Subregions in the ventromedial prefrontal cortex integrate threat and protective information to meta-represent safety [0.03%]
腹内侧前额叶皮层亚区整合威胁和保护信息以表征安全属性
Sarah M Tashjian,Joseph Cussen,Wenning Deng et al.
Sarah M Tashjian et al.
Pivotal to self-preservation is the ability to identify when we are safe and when we are in danger. Previous studies have focused on safety estimations based on the features of external threats and do not consider how the brain integrates o...