Splicing deficiency is driven by genomic erosion in non-recombining algal mating-type chromosomes [0.03%]
嫁接缺失由非重组藻类配子型染色体基因组侵蚀驱动
Chris Condon,Andrea Galvez,Alexander Kramer et al.
Chris Condon et al.
Splicing deficiency may represent a critical yet underexplored form of genomic erosion in non-recombining regions. Across four phytoplankton species diverged ~333-639 million years ago, genes within U (female) and V (male) "UV" mating-type ...
Ying Yao,Simon Hanslmayr
Ying Yao
A new study in PLOS Biology shows that neuronal firing is selectively tuned to oscillatory frequency in human intracranial recordings, complementary to phase tuning, suggesting an additional dimension in how brain rhythms may organize neura...
Teemu Kuosmanen,Juhani Rantanen,Dovydas Kičiatovas et al.
Teemu Kuosmanen et al.
Understanding and predicting how communities assemble is a paramount challenge in ecology. Here we address these questions normatively by comparing the observed species abundance distribution to a game-theoretically fair distribution based ...
Longitudinal lineage tracing reveals early clonal attrition during Drosophila midgut aging [0.03%]
纵向系谱追踪揭示了果蝇肠道上皮细胞在衰老过程中克隆选择的早期阶段
Han Gong,Kehui Liu,Shanjun Deng et al.
Han Gong et al.
The dynamics of stem cell maintenance and proliferative patterns are key determinants of tissue aging in multicellular organisms. Leveraging our previously developed SMALT system with enhanced sequencing compatibility, we performed longitud...
Web-based collaborative model development in interdisciplinary consortia: Design principles and practical guidance [0.03%]
基于网络的协作模型开发：跨学科联盟中的设计原则和实用指南
Marvin van Aalst,Alienor Lahlou,Tanvir Hassan et al.
Marvin van Aalst et al.
Web-based modeling platforms can enhance collaboration between modelers and experimentalists during early model development. Drawing on two interdisciplinary case studies, we provide guiding principles on how to build interactive agile mode...
Sleep deprivation increases levels of the synaptic density marker SV2A in the human brain [0.03%]
睡眠剥夺可增加人脑中突触密度标志物SV2A的水平
David Elmenhorst,Anna L Foerges,Ali Gordji-Nejad et al.
David Elmenhorst et al.
Sleep is essential for synaptic homeostasis, a proposed mechanism whereby wakefulness leads to synaptic potentiation and sleep facilitates synaptic down-selection. Synaptic vesicle glycoprotein 2A (SV2A), whose availability is quantifiable ...
Randomized Controlled Trial
PLoS biology. 2026 Jun 23;24(6):e3003816. DOI:10.1371/journal.pbio.3003816 2026
Human neuronal firing varies with the frequency of local field potential oscillations [0.03%]
人类神经元放电随局部场位震荡频率而变化
Zahra Jourahmad,Raissa K Mathura,Layth S Mattar et al.
Zahra Jourahmad et al.
Neural oscillations play a critical role in shaping neuronal firing patterns. While phase-locked neuronal firing ("phase tuning") has been extensively studied in animal models and human invasive recordings, much less is known about whether ...
The total mass, copy number, and distribution of hormones in the human bloodstream [0.03%]
人体血液中激素的总质量、拷贝数和分布状况
Ron Sender,Tal Kedar,Yoav Navon et al.
Ron Sender et al.
The human endocrine system orchestrates critical physiological processes, yet a systematic quantitative synthesis of clinically relevant circulating hormones has been lacking. Here, we present a comprehensive, integrative analysis of circul...
Growth arrest of Mycobacterium tuberculosis in acidic environments enhances their survival of antibiotic treatment [0.03%]
结核分枝杆菌在酸性环境中的生长停滞可增强其对抗生素治疗的抵抗力
Eun Seon Chung,William C Johnson,Maliwan Kamkaew et al.
Eun Seon Chung et al.
The ability of Mycobacterium tuberculosis (Mtb) to dynamically adjust its growth behavior in response to host environments is critical for survival under immune and drug stress, but how these behaviors shift at the single-cell level remains...
Distinct sources of decision-related signals in visual cortex are represented in different local field potential bands [0.03%]
视觉皮层中与决策相关的信号的不同来源在不同的局部场电位频带中得到表示
Yueyue Sapphire Hou,Pooya Laamerad,Liu D Liu et al.
Yueyue Sapphire Hou et al.
Fluctuations in single-neuron activity in the sensory cortex often correlate with perceptual decisions. This kind of correlation is often hypothesized to reflect a causal influence of sensory signals on decisions, but it can be attributed t...