The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination [0.03%]
芽孢和协同芽孢信号在难辨梭菌孢子萌发过程中通过CspC:CspA异二聚体转导
Morgan E McNellis,Gonzalo González-Del Pino,Juan A Serrano-Jiménez et al.
Morgan E McNellis et al.
The clinically significant pathogen Clostridioides difficile lacks the transmembrane nutrient germinant receptors conserved in almost all spore-forming bacteria. Instead, C. difficile initiates spore germination using a unique mechanism tha...
Epimutations driven by RNAi or heterochromatin evoke transient antimicrobial drug resistance in pathogenic Mucor fungi [0.03%]
由RNAi或异染色质驱动的表观遗传变异可使病原黏菌短暂耐受抗菌药物
Ye-Eun Son,Carlos Pérez-Arques,Joseph Heitman
Ye-Eun Son
Antimicrobial resistance (AMR) is a global health threat emerging through microbe adaptation, driven by genetic variation, genome plasticity or epigenetic processes. In this study, we investigated how the Mucor circinelloides species comple...
Knowledge gaps and research priorities to understand sex differences in immunity [0.03%]
探究免疫学性别差异的知识缺口和研究优先事项
Katie L Flanagan,Sabra L Klein
Katie L Flanagan
Differences in immunity in males and females throughout the life span manifest as differences in susceptibility to chronic diseases, infections, cancer, and responses to therapeutic interventions such as immunomodulatory drugs and vaccines....
A gut-activated NHR-86-CYP pathway mediates the neuroprotective effects of Enterococcus faecium probiotics in a nematode model of amyotrophic lateral sclerosis [0.03%]
肠激活的NHR-86-CYP途径介导了枯草芽孢杆菌益生菌在渐冻症线虫模型中的神经保护作用
Yu Sang,Jie Ren,Alejandro Aballay
Yu Sang
Neurodegenerative diseases are often associated with oxidative stress, and while probiotics may influence neuronal health, the underlying mechanisms remain poorly understood. Using the sod-1 A4VM amyotrophic lateral sclerosis (ALS) model in...
Microstructural profiles of the human superficial white matter and their associations to cortical geometry and connectivity [0.03%]
人脑浅白质的微观结构及其与皮层几何和连接的关系
Youngeun Hwang,Raul Rodriguez-Cruces,Jordan DeKraker et al.
Youngeun Hwang et al.
The superficial white matter (SWM), immediately beneath the cortical mantle, is thought to play a major role in cortico-cortical connectivity as well as large-scale brain function. Yet, this compartment remains rarely studied due to its com...
Five energy metabolism pathways show distinct regional distributions and lifespan trajectories in the human brain [0.03%]
五种能量代谢途径在人类大脑中的区域分布和寿命特征各不相同
Moohebat Pourmajidian,Justine Y Hansen,Golia Shafiei et al.
Moohebat Pourmajidian et al.
Energy metabolism involves a series of biochemical reactions that generate ATP, utilizing substrates such as glucose and oxygen supplied via cerebral blood flow. Energy substrates are metabolized in multiple interrelated pathways that are c...
Correction: Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of natural transformation within species [0.03%]
关于质粒和染色体移动遗传元件的基因组内冲突驱使种内自然转化进化观点的更正
Fanny Mazzamurro,Jason Baby Chirakadavil,Isabelle Durieux et al.
Fanny Mazzamurro et al.
[This corrects the article DOI: 10.1371/journal.pbio.3002814.]. Copyright: © 2026 Mazzamurro et al. This is an open access article distributed under the...
Published Erratum
PLoS biology. 2026 Jan 30;24(1):e3003628. DOI:10.1371/journal.pbio.3003628 2026
Correction: Oxygen supersaturation has negligible effects on warming tolerance across diverse aquatic ectotherms [0.03%]
订正：氧气过饱和对多样水生变温动物的耐暖性影响可以忽略不计
Graham D Raby,Jeremy De Bonville,Leroy Reynolds et al.
Graham D Raby et al.
[This corrects the article DOI: 10.1371/journal.pbio.3003413.]. Copyright: © 2026 Raby et al. This is an open access article distributed under the terms...
Published Erratum
PLoS biology. 2026 Jan 28;24(1):e3003626. DOI:10.1371/journal.pbio.3003626 2026
A deep learning-based computational pipeline predicts developmental outcome in retinal organoids [0.03%]
基于深度学习的计算管道预测视网膜类器官的发育结局
Cassian Afting,Norin Bhatti,Christina Schlagheck et al.
Cassian Afting et al.
Retinal organoids have become important models for studying development and disease, yet stochastic heterogeneity in the formation of cell types, tissues, and phenotypes remains a major challenge. This limits our ability to precisely experi...
Joanna Clarke,Claudio Mauro
Joanna Clarke
Immunometabolism describes more than just metabolic shifts in immune cells. A new collection of articles shines a light on the many facets of immunometabolism, exploring the effects of molecular, cellular, and systemic metabolic mechanisms ...