R Craig MacLean,Adam Mulkern,Liam P Shaw
R Craig MacLean
Why do even closely-related bacteria differ in their capacity to evolve antibiotic resistance? Drawing on evidence from experimental evolution, pathogen genomics, and molecular microbiology, this Essay argues that the evolution of antibioti...
The cell cloud: Adopting systems biology concepts in the era of single-cell immunology [0.03%]
细胞云：单细胞免疫学时代的系统生物学概念的应用
Tal Shay,Christophe O Benoist,Ricardo Grieshaber-Bouyer
Tal Shay
High-throughput single-cell assays reveal data that defies discrete categorization. The 'cell cloud' model, grounded in established systems biology principles, offers a framework to navigate biological plasticity alongside technical variabi...
Disinhibitory signaling enables flexible coding of top-down information in cortical networks [0.03%]
去抑制信号能使皮层网络灵活编码下行信息
Tomas G Aquino,Robert Kim,Nuttida Rungratsameetaweemana
Tomas G Aquino
Flexible behavior requires the ability to modulate sensory processing based on task context, yet the circuit-level mechanisms supporting this capacity remain poorly understood. Here, we combine recurrent neural network modeling and neural r...
Correction: Cdc42 interacts with chaperone Ydj1 to enhance its stability and partitioning during asymmetric cell division and aging in yeast [0.03%]
correction：cdc42与分子伴侣ydj1互作以增强其稳定性及芽殖分裂和酵母衰老过程中的分配非均匀性
PLOS Biology Staff
PLOS Biology Staff
[This corrects the article DOI: 10.1371/journal.pbio.3003306.]. Copyright: © 2026 The PLOS Biology Staff. This is an open access article distributed und...
Published Erratum
PLoS biology. 2026 Jul 2;24(7):e3003891. DOI:10.1371/journal.pbio.3003891 2026
Paulyna Magaña,Piraveen Gopalasingam,Jennifer R Fleming et al.
Paulyna Magaña et al.
Advances in artificial intelligence (AI)-driven bioinformatics promise democratized discovery, yet major inequities persist. Equitable adoption of bioinformatics tools will require sustained investment in infrastructure, training, instituti...
The human claustrum supports cognitive networks for externally and internally driven task demands [0.03%]
人类扣带皮层支持外在和内在任务需求的认知网络
Brent W Stewart,Matthew A Cormie,Michael L Keaser et al.
Brent W Stewart et al.
Cognitive control is believed to arise from task-dependent interactions among networks of brain regions. Although several debilitating neuropsychiatric disorders are characterized by cognitive network dysfunction, the neural circuit mechani...
Unusual decay: Recombination loss leads to splicing errors in green algae [0.03%]
不寻常的衰变：结合损失导致绿藻拼接错误
Anamaria Necsulea
Anamaria Necsulea
Recombination suppression leads to genomic erosion through an accumulation of deleterious mutations. A new study in PLOS Biology reveals an outstanding increase in aberrant splicing in non-recombining genomic regions in green algae. ...
Angptl5 restricts primitive hematopoiesis by promoting retinoic acid signaling in zebrafish [0.03%]
血管生成素样蛋白5通过促进斑马鱼原始造血的视黄酸信号限制原始造血
Jing Mo,Ding-Hao Zhuo,Min Gao et al.
Jing Mo et al.
Homeostasis is essential for hematopoiesis, and its dysregulation can lead to severe pathological conditions. Retinoic acid (RA) is a key regulator that exerts concentration-dependent effects on both embryonic and adult hematopoiesis. Howev...
Engineered bipaternal mice reveal the consequences of life without a maternal genomic contribution [0.03%]
工程化的双父系小鼠揭示了生命中缺乏母源基因组供体的影响
Si-Nan Ma,Fan Li,Yu-Long Zhao et al.
Si-Nan Ma et al.
Successful mammalian development normally requires contributions from both maternal and paternal genomes, yet how these parental components jointly shape organismal development remains incompletely understood. Using engineered bipaternal mi...
Multiple adhesion molecules act together in oligodendrocyte-mediated axonal selection and myelin formation [0.03%]
多种粘附分子在少突胶质细胞介导的轴突选择和髓鞘形成中共同起作用
Swathi Radha,Martina Arends,Georg Kislinger et al.
Swathi Radha et al.
Rapid information processing in complex organisms depends on myelin, which consists of a multilamellar membrane that tightly adheres to the axonal surface along the internode and at paranodal loops, where specialized adhesion proteins maint...