CUL5 E3 ubiquitin ligase regulates the evasion of bladder cancer cells to CD8+ T cell-mediated killing by inhibiting autophagy [0.03%]
CUL5 E3连接酶通过抑制自噬来调控膀胱癌细胞逃避CD8+t细胞介导的杀伤作用
Xincheng Gao,Yanchao Yu,Jiayin Sun et al.
Xincheng Gao et al.
CD8+ T cells are capable of specifically targeting and eliminating malignant tumor cells, but tumor cells can develop resistance mechanisms to escape CD8+ T cell-mediated killing. Here, we performed a whole genome CRISPR-Cas9 knockout scree...
Endocytic protein AP180 assembly domain regulates synaptic vesicle size and release in Caenorhabditis elegans [0.03%]
模式生物秀丽隐杆线虫的内吞蛋白AP180装配结构域调节突触囊泡大小及释放功能
Yu Wang,Lanxi Wu,Lin Zhang et al.
Yu Wang et al.
Neuronal communication relies on neurotransmitter release from synaptic vesicles. The endocytic protein AP180 is critical for efficient vesicle recycling at presynaptic terminals, and its loss impairs neurotransmission, producing reduced re...
Microglia sense fungal infections through capsular components from capillary-bound Cryptococcus neoformans via endothelial nucleotide signaling [0.03%]
小胶质细胞通过内皮核苷酸信号感应芽生菌病中的真菌感染
Chenxu Feng,Ge Wang,Yixuan Wang et al.
Chenxu Feng et al.
Macrophages are essential for host defense, yet how parenchyma-residing macrophages detect pathogens without direct contact remains unclear. Cryptococcus neoformans is an encapsulated fungal pathogen that infects the brain. Using in situ im...
The human dorsal anterior cingulate facilitates acceptance of unfair offers and regulates inequity aversion [0.03%]
人类背侧前扣带回促进不公平提议的接受并调节公平厌恶感
Shotaro Numano,Chris Frith,Masahiko Haruno
Shotaro Numano
Bargaining is a fundamental social behavior in which individuals often accept unfair offers. Traditional behavioral models, based solely on choice data, typically interpret such acceptance as simple reward-maximization. However, regulating ...
Human newborns form musical predictions based on rhythmic but not melodic structure [0.03%]
节奏而非旋律结构影响新生儿的音乐预期能力
Roberta Bianco,Brigitta Tóth,Felix Bigand et al.
Roberta Bianco et al.
The ability to anticipate rhythmic and melodic structures in music is considered a fundamental human trait, present across all cultures and predating linguistic comprehension in human development. Yet, it remains unclear the extent to which...
François Massol
François Massol
While clinical features of bacterial vaginosis have been amply described, its underlying causes are still debated. A new ecological model published in PLOS Biology provides a solid hypothesis corroborated by existing data, hinting at new pr...
Resource landscape shapes the composition and stability of the human vaginal microbiota [0.03%]
资源景观塑造人类阴道微生物群的组成和稳定性
Tsukushi Kamiya,Mircea T Sofonea,Michael France et al.
Tsukushi Kamiya et al.
The vaginal microbiota is associated with the health of women and newborns alike. Despite its comparatively simple composition relative to other human microbiota systems, the mechanisms underpinning the dynamics and stability of vaginal mic...
Recurrent mutations in the stress regulator Cap1 reveal a trade-off between azole resistance and oxidative stress response in Candida albicans [0.03%]
卡氏肺孢菌中应激调节因子Cap1的重复突变揭示了唑类抗性和氧化应激反应之间的权衡关系
Xin Zhou,Audrey Hilk,Norma V Solis et al.
Xin Zhou et al.
Drug resistance is a critical challenge in treating life-threatening fungal infections. Here, we uncover a mechanism of acquired azole resistance in Candida albicans through mutations in CAP1, encoding a conserved fungal transcription facto...
DNA damage induced by HIV-1 Vpr triggers epigenetic remodeling and transcriptional programs to enhance virus transcription and latency reactivation [0.03%]
HIV-1蛋白Vpr通过诱导DNA损伤触发表观遗传修饰和转录程序来增强病毒转录及潜伏感染的激活
Nicholas Saladino,Emily Leavitt,Hoi Tong Wong et al.
Nicholas Saladino et al.
Hijacking of host DNA damage repair (DDR) pathways to facilitate virus replication is broadly conserved amongst diverse viral families. It has been well established that the HIV-1 accessory protein Vpr induces constitutive DDR signaling and...
Grik2b and Grik2c kainate receptors regulate oviposition in Bactrocera dorsalis [0.03%]
番木瓜灰粉甲Grik2b和Grik2c谷氨酸受体调控产卵行为
Bin Liu,Jingwei Yang,Long Ye et al.
Bin Liu et al.
Oviposition holds crucial significance for insect reproduction. Nevertheless, the research on the neural conduction mechanism of oviposition is still rather limited in most agricultural pests. Here, we demonstrate that the conserved Kainate...