New approaches to meta-analyze differences in skewness, kurtosis, and correlation [0.03%]
用于分析偏度、峰度和相关性差异的新方法
Pietro Pollo,Szymon M Drobniak,Hamed Haselimashhadi et al.
Pietro Pollo et al.
Biological differences between males and females are pervasive. Researchers often focus on sex differences in the mean or, occasionally, in variation, albeit other measures can be useful for biomedical and biological research. For instance,...
James E Niemeyer
James E Niemeyer
Epilepsy is thought to develop through pathological connections involving various and widespread brain regions. A new study in PLOS Biology shows how some of these connections are formed across network sites, and how this interconnectivity ...
Synapse types are spatially associated with regional hemodynamics in the mouse brain [0.03%]
小鼠大脑中突触类型与区域血动力学在空间上相关
Justine Y Hansen,Andrea I Luppi,Zhen Qiu et al.
Justine Y Hansen et al.
Synapses are the connections that transform neurons from simple electrically charged cells into complex circuits that support perception, cognition and action. Recent advances in single-punctum synapse mapping in mice make studying synapse ...
Integrated chromatin and transcriptomic profiling reveals sex-specific mechanisms of gene regulation in hepatic nutrient responses [0.03%]
整合染色质和转录组分析揭示了肝脏营养反应中性别特异性基因调控机制
Zhengyi Zhang,Vivien Su,Carrie B Wiese et al.
Zhengyi Zhang et al.
Little is known about how sex and diet interact at the level of chromatin organization. A comprehensive analysis of diet-induced chromatin dynamics can reveal how the liver mounts a rapid adaptive response to environmental cues and uncover ...
Cdc42 interacts with chaperone Ydj1 to enhance its stability and partitioning during asymmetric cell division and aging in yeast [0.03%]
CDC42通过与分子伴侣YDJ1相互作用在酵母的不对称细胞分裂和衰老过程中增强其稳定性和分离子代细胞时的不均等分配
Pil Jung Kang,Hana Mazak,Sung Sik Lee et al.
Pil Jung Kang et al.
Cdc42, a small GTPase essential for cell polarity, often becomes hyperactive with age and promotes senescence in yeast and animal cells. Yet, the mechanisms driving its age-related upregulation remain unclear. Here, we show that in budding ...
Piriform seizures mediated by the piriform-entorhino-dentate circuit induce brain-wide functional reorganization in mice [0.03%]
梨状皮质癫痫通过梨状回-内侧嗅周皮质-齿状回环路诱导全脑功能重塑
Yan Tao,Yuxin Zhao,Wenqi Zhong et al.
Yan Tao et al.
Systematic identification of global epileptic reorganization and critical seizure-controlling circuits is essential for comprehending epilepsy pathophysiology and for developing network-guided targeted therapies. The piriform cortex (PC) is...
Marcus R Munafò,George Davey Smith
Marcus R Munafò
Improvements to scientific methods and approaches should, in theory, mean more robust evidence and inference, and more rapid advances in knowledge. In practice, they have led to an increasing number of poor-quality studies. Can we break thi...
A cost-effective and scalable barcoded library construction method for deep mutational scanning studies [0.03%]
一种用于深度突变扫描研究的低成本且可扩展的条形码库构建方法
Jessica Jann,Isabelle Gagnon-Arsenault,Alicia Pageau et al.
Jessica Jann et al.
Recent developments in DNA synthesis and sequencing allowed the construction of comprehensive gene variant libraries and their functional analysis. Achieving high-replication and thorough mutation characterization remains technically and fi...
Augmentation of frontoparietal gamma-band phase coupling enhances human altruistic behavior [0.03%]
前顶叶γ频段相位耦合增强人类利他行为
Jie Hu,Marius Moisa,Christian C Ruff
Jie Hu
Cooperation, productivity, and cohesion in human societies depend on altruism, the tendency to share resources with others even though this is costly. While altruism is a widely shared social norm, people vary strongly in their inclination ...
Correction: Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in the fungal pathogen Histoplasma [0.03%]
Correction: 一条染色体的快速获得和丢失驱动了重要真菌病原体荚膜组织胞浆菌的关键形态和毒力特征
PLOS Biology Staff
PLOS Biology Staff
[This corrects the article DOI: 10.1371/journal.pbio.3003224.]. Copyright: © 2026 The PLOS Biology Staff. This is an open access article distributed und...
Published Erratum
PLoS biology. 2026 Feb 10;24(2):e3003651. DOI:10.1371/journal.pbio.3003651 2026