Meis1 isoform diversity orchestrates neural progenitor differentiation by regulating ATOH1 degradation at distinct subcellular compartments [0.03%]
Meis1通过在不同的细胞器中调节Atoh1的降解来调控神经前体分化中的异质性
Tomoo Owa,Toma Adachi,Ryo Shiraishi et al.
Tomoo Owa et al.
The development of the complex nervous system is strictly controlled by diverse isoforms produced from individual genes, but the underlying machinery remains unclear. Our long-read cDNA sequencing of mouse cerebellar granule cell progenitor...
Social learning dynamically shapes moral decision-making by biasing subjective valuation [0.03%]
社会学习通过影响主观评价动态地塑造道德决策制定
Julien Benistant,Valentin Guigon,Alain Nicolas et al.
Julien Benistant et al.
Observing immoral behavior increases one's dishonesty by social influence and learning processes. The neurocomputational mechanisms underlying such moral contagion remain unclear. We tested different mechanistic hypotheses to account for mo...
Wanting this, not that: The neural circuit that turns specific expectations into actions [0.03%]
求此避彼：将特定预期转变为行动的神经环路
Joey A Charbonneau,Erin L Rich
Joey A Charbonneau
Neuroeconomics has long focused on reward values, ignoring their identity. A new PLOS Biology study shows that identity-specific reward expectations in the lateral orbitofrontal cortex steer goal-directed choices through a motivational circ...
Dipteran flight diversity is shaped by aerodynamic constraints, scaling, and evolutionary trade-offs [0.03%]
气动约束、尺度及进化权衡影响双翅目昆虫飞行多样性
Camille Le Roy,Ilam Bharathi,Thomas Engels et al.
Camille Le Roy et al.
Flight has been a key innovation in insect evolution, yet the selective and mechanistic pressures shaping their flight motor systems remain poorly understood. Here, we present a comprehensive comparative analysis of flight in Diptera (true ...
Identity-specific reward expectations in orbitofrontal cortex guide goal-directed choices [0.03%]
眶额皮层中的身份特异性奖赏预期指导目标导向性选择
Phillip P Witkowski,Noelle Henein,Nicole Moussa et al.
Phillip P Witkowski et al.
Real-life decisions are typically directed toward specific types of rewards (e.g., a slice of pizza or a bowl of pasta), but reward identity is often neglected in neuroeconomic theories of decision-making. Previous research has shown that t...
GABA neurons in the sublaterodorsal tegmental nucleus suppress wakefulness in healthy and narcoleptic mice [0.03%]
小脑顶核的GABA能神经元通过抑制健康小鼠和发作性睡眠病模型小鼠的清醒状态而发挥作用
HanHee Lee,Jimmy J Fraigne,John H Peever
HanHee Lee
The sleep-wake cycle is generated by competing neural circuits that control the oscillation between wakefulness, rapid eye movement (REM) sleep, and non-REM (NREM) sleep. While the sublaterodorsal tegmental nucleus (SLD) is recognized for i...
A developmental shift in glucocorticoid receptor expression preserves glucocorticoid sensitivity in the adult suprachiasmatic nucleus [0.03%]
糖皮质激素受体表达的发育性变化可保护视交叉上核中糖皮质激素的敏感性
Kristian Händler,Varun K A Sreenivasan,Violetta Pilorz et al.
Kristian Händler et al.
The circadian system synchronizes physiology, improving the adaptation to daily environmental changes. In mammals, the central pacemaker, in the suprachiasmatic nuclei (SCN) of the hypothalamus, coordinates "wake" functions by inducing the ...
Sequential neural dynamics underlie unconscious integration and conscious perception of visual stimuli [0.03%]
序列神经动力学决定了视觉刺激的非意识整合和意识感知
Maëlan Q Menétrey,Michael H Herzog,David Pascucci
Maëlan Q Menétrey
In some forms of postdictive phenomena, later events influence the perception of earlier ones, suggesting that conscious perception may be preceded by extended periods of unconscious processing. An example is the Sequential Metacontrast (SQ...
Engineering resilient gene drives for sustainable malaria control by predicting, testing and overcoming target site resistance in Anopheles gambiae [0.03%]
通过预测、测试和克服冈比亚按蚊中的靶基因抗性来工程设计可持续疟疾控制的稳健基因驱动路径
Ioanna Morianou,Lee Phillimore,Bhavin S Khatri et al.
Ioanna Morianou et al.
CRISPR-based gene drives are selfish genetic elements with the potential to spread through entire insect populations for sustainable vector control. Gene drives designed to disrupt the reproductive capacity of females can suppress laborator...
Shared memories of event details in the human brain are altered by misinformation and test expectations [0.03%]
误导信息及测验预期会影响人脑中对事件细节的共同记忆
Xuhao Shao,Chuansheng Chen,Elizabeth F Loftus et al.
Xuhao Shao et al.
Shared memories of event details are crucial to eyewitness testimony. When different people encode or recall the same event, similar scene-specific neural activity patterns emerge across individual brains. However, it remains unclear whethe...