sept-1/zina-1 is an ancient toxin-antidote system in Caenorhabditis elegans [0.03%]
Sept-1/ZIN-1 是Caenorhabditis elegans中的一个古老的毒抗系统
Dongyao Liu,Chaogu Zheng
Dongyao Liu
The toxin-antidote (TA) systems, consisting of two tightly linked genes acting as a postzygotic distorter, are found in several eukaryotic organisms, including three androdioecious Caenorhabditis species. However, the evolutionary history o...
Clonal drift in the aging gut: Mapping the fate of stem cells over time [0.03%]
衰老肠道中的克隆漂变：随时间追踪干细胞的命运
Tzu-Chiao Lu,Hongjie Li
Tzu-Chiao Lu
Aging tissues gradually lose cellular diversity due to stem cell exhaustion. A new PLOS Biology study utilizes advanced lineage tracing to track intestinal stem cell lineages across the life span. The findings reveal clonal attrition happen...
Why biology must prioritize data reanalysis in the era of artificial intelligence [0.03%]
人工智能时代背景下生命科学须重视数据再分析
Daniel Ghaderi,Ali Sahimi,Benjamin Esser et al.
Daniel Ghaderi et al.
New technologies have generated huge volumes of biological data, much of which is underutilized. AI-assisted data reanalysis could drive the next era of biological discovery, but realizing its full potential requires standards, validation, ...
Comparative single-nucleus transcriptomics reveals asymmetric evolution of the Drosophila male and female germlines [0.03%]
比较单细胞核转录组学揭示了果蝇雄性和雌性生殖系的非对称演化
Imtiyaz E Hariyani,Sudeshna Das,Emma M Le et al.
Imtiyaz E Hariyani et al.
Reproductive organs vary widely across species yet share conserved cell types that produce gametes, sustaining species' perpetuation. However, tissue-level comparisons mask critical differences among cell types, obscuring where evolutionary...
Comparative Study
PLoS biology. 2026 Jul 20;24(7):e3003869. DOI:10.1371/journal.pbio.3003869 2026
Noise-invariant representations of sound emerge along the canonical cortical hierarchy [0.03%]
典型皮层层次中声音不变表征的产生
Tomas Suarez Omedas,Ross S Williamson
Tomas Suarez Omedas
Neurons in the auditory system must represent behaviorally relevant sounds in the presence of background noise (BN) to support noise-invariant perception and behavior. Although the primary auditory cortex (ACtx) has been implicated in const...
Retrosplenial cortical reorganization during late adolescence introduces instability of contextual memory circuits [0.03%]
顶叶皮层在青少年晚期的重构会引入情境记忆回路的不稳定性
Hui Zhang,Zorica Petrovic,Elizabeth M Wood et al.
Hui Zhang et al.
Hippocampal and cortical memory circuits, which enable the capacity to remember details from one's past, are believed to reach maturity by early adolescence. Here, we demonstrate that the transition from early to late adolescence involves e...
Neuronal protein Sex-lethal modulates tRNA synthesis via the polymerase III subunit Polr3E in male Drosophila neurons [0.03%]
神经蛋白Sex-lethal通过tRNA合成中的III型聚合酶亚基Polr3E在雄性果蝇神经元中发挥调节作用
Freya Storer,Colin D McClure,Alicia Estacio Gomez et al.
Freya Storer et al.
The RNA-binding protein Sex-lethal (Sxl) is classically known as a master regulator of sex determination and mRNA splicing in Drosophila melanogaster. However, this role is not conserved across species, and functions beyond the canonical pa...
Queuosine tRNA modification regulates translational adaptation and virulence of Leishmania mexicana [0.03%]
Queuosine的tRNA修饰调节莱什曼原虫的翻译适应性和致病性
Bankatesh Kumar,Julie Kovářová,Michala Boudová et al.
Bankatesh Kumar et al.
The complex life cycle of the human parasite Leishmania mexicana requires rapid translational adaptation for survival in two distinct environments: the insect vector and the mammalian host. These protists lack conventional transcriptional c...
A high-resolution phenotypic screen identifies regulators of CNS axon diameter in zebrafish [0.03%]
斑马鱼高通量表型筛选鉴定出调控CNS轴突直径的新基因
Maria A Eichel-Vogel,Daniel Y H Soong,Melody N Sequeira et al.
Maria A Eichel-Vogel et al.
The molecular mechanisms underpinning neuronal morphogenesis remain to be fully understood. A powerful step in uncovering the molecular basis of biological processes is the execution of discovery screens in model systems. Here, we employed ...
The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy [0.03%]
皮质层级精准预测误差权衡中心的灵长类丘脑下板区研究
Yujie Hou,Alessandra Pizzuti,Kenneth Knoblauch et al.
Yujie Hou et al.
Understanding how signals are exchanged across the cerebral cortex is a central challenge for theories of perception and cognition. Although crucial gaps exist in empirical knowledge, evidence is emerging in macaques for complementary funct...