The long horizon of animal study preregistration: Attitudes, barriers, and myths [0.03%]
动物研究预注册的长期前景：态度、障碍和误区
Pasquale Pellegrini,Ulf Toelch
Pasquale Pellegrini
Nearly half of Swiss animal researchers have never heard of preregistration. A survey published in PLOS Biology maps their attitudes, barriers, and misconceptions, and identifies what it would take to change minds. ...
Editorial Note: A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth [0.03%]
编者按：非酶依赖性inositol要求的酶1控制癌细胞周期进展和肿瘤生长
PLOS Biology Editors
PLOS Biology Editors
Structural snapshots of the glucose-6-phosphate/phosphate exchange cycle [0.03%]
葡萄糖-6-磷酸/磷酸交换循环的结构快照
Lin Kevin Qi,Cheng Shen,Motoyuki Hattori
Lin Kevin Qi
SLC37A4 mediates glucose-6-phosphate transport for glucose homeostasis. Two recent studies in PLOS Biology report its structures and, together with other reports, illuminate the glucose-6-phosphate/phosphate exchange cycle and its inhibitio...
Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4 [0.03%]
人类葡萄糖-6-磷酸盐转运蛋白SLC37A4的底物识别及抑制的结构基础
Hui Li,Xiaomin Peng,Yuwen Huang et al.
Hui Li et al.
Glucose 6 phosphate (G6P) homeostasis is essential for maintaining blood glucose levels and coordinating anabolic and catabolic pathways. A key step in this process is the delivery of G6P into the endoplasmic reticulum (ER), where it is hyd...
A survey of researchers' attitudes to preregistration in animal research reveals multiple perceived barriers to adoption [0.03%]
一项针对动物研究者在预注册态度的调查揭示了多个采纳的障碍
Cristina Priboi,Boris Mayer,Evie Vergauwe et al.
Cristina Priboi et al.
Preregistration is arguably one of the most promising and potentially impactful Open Science practices. Defined as the a priori registration of study designs and analysis plans, preregistration has long been established as standard practice...
Joe G Greener
Joe G Greener
Structural bioinformatics aims to answer biological questions by considering biomolecular structures at scale. We now have accurate predictions and need to ask what we can learn from them. ...
Competing value signals impair reward-learning via dopaminergic mechanisms and increase exploration [0.03%]
竞争的价值信号通过多巴胺机制损害奖励学习并增加探索行为
Wen-Wei Lin,Pei-Yu Lee,Hsin-Yun Tsai et al.
Wen-Wei Lin et al.
Effective reinforcement learning requires balancing exploration of uncertain options with exploitation of known outcomes. In real-world contexts, the same action may yield rewards in some situations and punishments in others, yet how these ...
Cell type-specific Ca2+ signals govern mouse seminiferous tubule physiology [0.03%]
细胞类型特异性钙信号控制小鼠生精小管生理功能
Justine A Fischoeder,David Fleck,Jerome Schröer et al.
Justine A Fischoeder et al.
Spermatogenesis, the complex developmental process of male germ cell proliferation, differentiation, and maturation, is the basis of male fertility. In the seminiferous tubules of the testes, spermatozoa are constantly generated from sperma...
A desynchrony mechanism between events triggers a compensatory delay during Caenorhabditis elegans development [0.03%]
事件脱节机制在秀丽隐杆线虫发育过程中触发补偿性延迟
Francisco Javier Romero-Expósito,Almudena Moreno-Rivero,Marta Muñoz-Barrera et al.
Francisco Javier Romero-Expósito et al.
In multicellular organisms, development entails the progression of diverse cellular processes that need to be temporally coordinated. During Caenorhabditis elegans postembryonic development, the events of molting and cell divisions progress...
Carina F Mugal,Marie Sémon
Carina F Mugal
A new study in PLOS Biology shows that in Drosophila, patterns of molecular evolution differ between genes expressed during oogenesis and spermatogenesis. Their evolutionary framework provides a basis for better understanding the link betwe...