A GABAergic network from AVP- to VIP-neurons in the suprachiasmatic nucleus sets the timing of circadian behavior rhythms [0.03%]
下丘脑血管加压素神经元至肽能神经元的γ-氨基丁酸能神经网络设定昼夜节律行为的时间点
Yubo Peng,Yusuke Tsuno,Takashi Maejima et al.
Yubo Peng et al.
The central circadian clock of the suprachiasmatic nucleus (SCN) consists of a network of multiple types of γ-aminobutyric acid (GABA)-ergic neurons and glial cells. However, the precise role of GABAergic transmission in the SCN remains un...
Sub-daily virus sampling at the Bermuda Atlantic Time Series reveals diel and depth-structured population dynamics without community-level shifts [0.03%]
伯曼达大西洋时间序列的亚日病毒采样揭示了昼夜和深度结构化的人口动态变化，而没有社区层面的变化
Alfonso Carrillo,Emily Hageman,Lauren Chittick et al.
Alfonso Carrillo et al.
Ocean microbes contribute to biogeochemical cycles and ecosystem function, but they do so under top-down pressure imposed by viruses. While viruses are increasingly understood spatially and beginning to be incorporated into predictive model...
The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice [0.03%]
衔接蛋白TASL是小鼠年龄相关B细胞产生和狼疮样疾病发生所必需的
Julia C Johnstone,Robert Mitchell,Timothy J Vyse et al.
Julia C Johnstone et al.
The autoimmune disease systemic lupus erythematosus (SLE) is associated with genetic variants in the X-linked gene CXORF21, which encodes the protein TASL. TASL acts as an adaptor in the IRF5 pathway and is necessary for the phosphorylation...
Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity [0.03%]
GPC3通过选择性抑制饮食诱导的肥胖小鼠的皮下脂肪生成来调节脂肪组织重塑
Yan Li,Ming Tao,Carlos F Ibáñez et al.
Yan Li et al.
Subcutaneous and visceral adipose depots employ distinct expansion strategies in response to dietary cues, yet the molecular regulators underlying these depot-specific adaptations remain poorly understood. Through integrated proteomic profi...
Developing monoclonal antibody therapies for measles could lead to adverse pathogen evolution [0.03%]
针对麻疹开发单克隆抗体疗法可能导致不利的病原体进化
David A Kennedy
David A Kennedy
Monoclonal antibody therapies are being developed to treat measles in response to its recent resurgence. These therapies risk driving measles virus evolution in ways that might undermine the protection offered by vaccination, outweighing po...
Magnesium depletion by Candida albicans unleashes two unusual modes of colistin resistance in Pseudomonas aeruginosa with different fitness costs [0.03%]
白色念珠菌通过消耗镁离子诱导铜绿假单胞菌产生两种罕见的多黏菌素耐药模式及适应性代价
Yu-Ying Phoebe Hsieh,Ian P O&#x;Keefe,Zeqi Wang et al.
Yu-Ying Phoebe Hsieh et al.
Increasing bacterial resistance to colistin, a vital last-resort antibiotic, is an urgent challenge. Previous studies have shown that Mg2+ depletion enables Pseudomonas aeruginosa to become resistant to colistin. Here, we show that magnesiu...
Glutamatergic projections from the substantia nigra pars reticulata to the dorsal raphe nucleus regulate male social hierarchies [0.03%]
中脑黑质网状部的谷氨酸能神经元及其在调控雄性社交地位的作用
Yanzhu Fan,Shaoxiang Ge,Lidi Lu et al.
Yanzhu Fan et al.
Social hierarchy constitutes a fundamental organizational characteristic among various social species, significantly influencing individual survival, health, and reproductive success within these societies. Neurons in the substantia nigra p...
Thomas A O&#x;Shea-Wheller,Katie I Murray
Thomas A O&#x;Shea-Wheller
Creating generalizable models is a conserved aim in deep learning-however, misleading claims of transferability threaten to obfuscate reliable performance evaluation. We outline the severity of this issue in the biosciences, and suggest pot...
Dynamic expectation strength and precision shape human pain perception through shared and dissociable α-oscillatory mechanisms [0.03%]
动态预期强度和精确度通过共享和不同的α振荡机制塑造人类的疼痛感知
Jia Li,Shihao Chen,Libo Zhang et al.
Jia Li et al.
Human pain perception is not solely driven by sensory input but is dynamically modulated by what we expect to feel and how confident we are in those expectations. Yet, the temporal mechanisms through which evolving expectations shape pain r...
Ischemic stroke triggers brain-wide synaptic remodeling within four hours [0.03%]
缺血性脑卒中在四小时内触发全脑范围的突触重塑
Huanhuan Chen,Ye Wei,Luminiţa Ruje et al.
Huanhuan Chen et al.
Physiological mechanisms of the key hyperacute (0-24 hours) stage of stroke are poorly understood, hampering the development of new therapies. Synaptic plasticity has been strongly implicated in early stages of neurodegenerative and neurode...