Thalamic reticular neurons provide cell type-specific modulation of sound processing in the auditory thalamus [0.03%]
丘脑核团神经元特异调节听觉丘脑的声音处理过程
Solymar Rolón-Martínez,Austin J Mendoza,Christopher F Angeloni et al.
Solymar Rolón-Martínez et al.
Inhibition plays an important role in controlling the flow and processing of auditory information throughout the central auditory pathway, yet how inhibitory circuits shape auditory processing in the medial geniculate body (MGB), the key re...
USP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice [0.03%]
USP7通过调节小鼠肌肉型磷酸果糖激酶的核转位来促进脑肿瘤在葡萄糖剥夺情况下的存活
Siyang Wu,Ruixiu Cao,Xiaolan Huang et al.
Siyang Wu et al.
Cancer cells reprogram the metabolic pathways to adapt to nutrient deficiency, while the underlying mechanism has not been fully understood. Phosphofructokinase 1 muscle type (PFKM) is the second rate-limiting step of glycolysis, catalyzing...
Cortisol treatment impairs path integration and alters grid-like representations in the male human entorhinal cortex [0.03%]
皮质醇治疗损害路径整合并改变男性内侧颞叶脑区的网格状神经元表征
Osman Akan,Varnan Chandreswaran,Henry D Soldan et al.
Osman Akan et al.
Acute stress triggers the release of cortisol, which broadly affects cognitive processes. Path integration, a specific navigational process, relies heavily on grid cells in the entorhinal cortex. The entorhinal cortex contains glucocorticoi...
Manoj Thapa,Anuradha Kumari,Chui-Yoke Chin et al.
Manoj Thapa et al.
Recent advances suggest a correlation between gut dysbiosis and neurological diseases, however, relatively little is known about how gut bacteria impact the brain. Here, we reveal that bacteria can translocate directly from the gut to the b...
A bacterial ecocline in Klebsiella pneumoniae may explain its backboned phylogeny [0.03%]
克雷伯氏肺炎菌中的一条细菌生态梯度可以解释它的主干系统发育关系
Siqi Liu,Sarah L Svensson,Daniel Falush
Siqi Liu
The genetic structure of bacterial species is most often interpreted in terms of demographic processes such as clonal descent, but can also reflect natural selection and hence give functional and ecological insight. Klebsiella pneumoniae (K...
The retrieval of previously learned motor memories is facilitated by the reinstatement of default mode network manifold structures [0.03%]
默认模式网络流形结构的恢复促进先前学习的运动记忆的检索
Ali Rezaei,Corson N Areshenkoff,Daniel J Gale et al.
Ali Rezaei et al.
Motor learning induces alterations in neural activity that can persist long after the effects of such learning have faded. These persistent neural alterations are thought to manifest behaviorally as "savings," or faster relearning, via acce...
Transposable elements contribute substantially to naturally occurring genetic lethality in Drosophila melanogaster [0.03%]
转座子在果蝇自然发生的遗传致死中起重要作用
Sarah B Marion,Katrina Focht,Iman Hamid et al.
Sarah B Marion et al.
Recessive lethal mutations are widespread across studied species, with estimates suggesting that each individual carries at least one. Numerous lethal alleles persist in wild populations at higher frequencies than expected given their extre...
Tom Tregenza,Rolando Rodríguez-Muñoz,Alfredo F Ojanguren et al.
Tom Tregenza et al.
Parental age and inbreeding have both been shown to have substantial fitness effects in laboratory experiments and in observations of wild animals. These demographic effects are likely to be strongly impacted by habitat fragmentation and wa...
Cis-regulatory evolution of Wnt family genes contributes to a morphological difference between silkworm species [0.03%]
丝蛋白基因顺式调控的表观遗传进化是家蚕形态差异的重要因素
Kenta Tomihara,Ana Pinharanda,Young Mi Kwon et al.
Kenta Tomihara et al.
Closely related species often exhibit distinct morphologies that can contribute to species-specific adaptations and reproductive isolation. One example is Lepidopteran caterpillar appendages, such as the "caudal horn" of Bombycoidea moths, ...
Expanding invasive species impact assessments to the ecosystem level with EEICAT [0.03%]
生态系统影响评估入侵物种的影响
Laís Carneiro,Daniel Pincheira-Donoso,Boris Leroy et al.
Laís Carneiro et al.
The ecological impacts of biological invasions vary widely in type, scale, and severity, highlighting the need for consistent assessment tools. The Environmental Impact Classification for Alien Taxa (EICAT) provides a standardized framework...