let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation [0.03%]
LIN28 型 RNA 结合蛋白是线虫发育时间调控中 let-7 miRNA 和 lin-46 mRNA 的重要靶分子
Jana Brunner,Anca Neagu,Dimos Gaidatzis et al.
Jana Brunner et al.
The RNA-binding protein (RBP) LIN28 is a key regulator of temporal cell fates, promoting stem cell identity and suppressing differentiation. It regulates the processing of the let-7 miRNA but additionally binds thousands of mRNAs, suggestin...
TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development [0.03%]
TAK1在非经典的TGFB/BMP信号传导中作用于主纤毛以控制心脏发育
Canan Doganli,Oskar Kaaber Thomsen,Daniel A Baird et al.
Canan Doganli et al.
Pathogenic variants in the genes encoding the non-canonical TGFB signaling components TAK1 (MAP3K7), TAB2 and PKA-Cα (PRKACA) cause rare multisystem disorders, which may include congenital heart disease (CHD). To investigate the role of TA...
John S Tregoning
John S Tregoning
How we write scientific papers does not reflect how we do science. Their formal structure infers a pre-ordained linear process rather than reflecting the messy creativity of research. This matters in the AI age because it masks the human in...
Editorial Note: Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells [0.03%]
编者按：干扰素调节因子4介导多发性骨髓瘤细胞中非酶促IRE1依赖性
PLOS Biology Editors
PLOS Biology Editors
Developmental factors drive the compartmentalized and discontinuous maturation of the small intestinal epithelium during the early postnatal period [0.03%]
发育因素驱动小肠上皮在产后早期阶段的隔室化和不连续成熟
Johannes Schöneich,Aline Dupont,Stefan Schlößer et al.
Johannes Schöneich et al.
The temporal, spatial, and cellular diversity of the small intestinal epithelium during the postnatal period, a critical time window that accompanies the transition from placental energy supply to enteral feeding, and the establishment of t...
The subthalamic nucleus-ventral pallidum projection targeting cholinergic circuits modulates chronic pain [0.03%]
靶向胆碱能环路的底丘脑核-腹侧被盖体投射调节慢性疼痛
Ya-Wei Ji,Xiang-Ying Xu,Qiang-Qiang Zhou et al.
Ya-Wei Ji et al.
The cholinergic system shows promise for pain management. Although cholinergic neurons in the ventral pallidum (VP) are involved in neuropathic pain, the anatomical organization and pharmacology of the cholinergic circuit contributing to th...
grafify online: A web app for graphing and statistical analysis [0.03%]
在线绘图和统计分析的网络应用程序 Grafify Online
Avinash R Shenoy
Avinash R Shenoy
grafify online is a free, browser-based app for generating publication-quality graphs and performing statistical tests and post-hoc comparisons. Users can customize plots and explore statistical results without needing R programming experie...
Endogenous auditory and motor brain rhythms predict individual speech tracking [0.03%]
内源性听觉和运动脑节律预测个体言语跟踪能力
Christina Lubinus,Anne Keitel,Jonas Obleser et al.
Christina Lubinus et al.
Slow, endogenous brain rhythms in the auditory cortex are hypothesized to track acoustic amplitude modulations during speech comprehension. Temporal predictions from the motor system are thought to enhance this tracking. However, direct evi...
Viruses help shape microbiome response to polyphenol rewiring of methane-suppressed peat microcosms [0.03%]
病毒帮助塑造甲烷抑制泥炭微宇宙中多酚重构的微生物组响应
James Riddell V,Rokaiya Nurani Shatadru,Garrett J Smith et al.
James Riddell V et al.
Human activities are accelerating permafrost thaw and subsequent methane emissions from increased microbial activity, prompting microbiome engineering efforts as an emissions mitigation strategy. We recently demonstrated that catechin amend...
siRNA-guided DNA-methylation at a sucrose transporter gene potentially contributes to climatic plant adaptation [0.03%]
基于siRNA引导的蔗糖转运蛋白基因DNA甲基化在植物气候适应性中的潜在作用
Jianqiu Li,Min Song,Qiyu Xu et al.
Jianqiu Li et al.
Climatic adaptation of plants involves the adjustment of carbon transport to achieve an optimal balance between carbon assimilation and carbon utilization. This study describes a potential molecular mechanism of this adjustment by investiga...