Yasunori Sasakura
Yasunori Sasakura
Tunicates are the closest living relatives of vertebrates, but many details of their evolutionary history remain unclear. A study published in PLOS Biology explores the unique embryogenesis of Thaliacea, the tunicates that regained mobility...
Fine-tuning ERK activity enables proliferation-differentiation balance during lineage specification of human embryonic stem cells [0.03%]
精 Tuning ERK 活性可在人胚胎干细胞谱系决定过程中使增殖分化保持平衡
Chenyang Ma,Weikang Meng,Jinghan Huang et al.
Chenyang Ma et al.
ERK is a key signaling mediator controlling both proliferation and lineage specification during embryo development. How ERK choreographs differentiation and proliferation to achieve balanced developmental outcomes in lineages with variable ...
The Rpd3 histone deacetylase is a critical regulator of temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma [0.03%]
Rpd3组蛋白脱乙酰基酶是调节人类真菌病原体球孢子菌温控形态生发和致病性的关键因子
Nebat Ali,Mark Voorhies,Rosa A Rodriguez et al.
Nebat Ali et al.
Adaptive responses to environmental stimuli are integral to the survival and virulence of microbial pathogens. The thermally dimorphic human fungal pathogen Histoplasma senses temperature to transition between a mold form in soil and a path...
PLOS Biology
PLOS Biology
[This corrects the article DOI: 10.1371/journal.pbio.0000036.]. Copyright: © 2026 PLOS Biology. This is an open access article distributed under the ter...
Published Erratum
PLoS biology. 2026 Mar 17;24(3):e3003714. DOI:10.1371/journal.pbio.3003714 2026
Systematic identification of Salmonella T6SS effectors uncovers diverse new families and lipid-targeting activities [0.03%]
系统识别沙门氏菌T6SS效应物揭示了新的多功能脂质靶向活性
Gianlucca G Nicastro,Stephanie Sibinelli-Sousa,Julia T Hespanhol et al.
Gianlucca G Nicastro et al.
Bacterial warfare is a widespread phenomenon in which bacteria deploy toxins to inhibit or kill competitors. These toxins disrupt essential cellular processes, and their diversification is driven by an evolutionary arms race involving toxin...
Engineered romidepsin biosynthetic pathways in Escherichia coli Nissle 1917 improve the efficacy of bacteria-mediated cancer therapy [0.03%]
工程化的ромидеپсин生物合成途径改善了大肠杆菌Nissle 1917介导的癌症治疗疗效
Chenghao Ma,Geng Li,Tao Sun et al.
Chenghao Ma et al.
The probiotic strain Escherichia coli Nissle 1917 (EcN), a potential member of tumor-targeting bacteria, shows great promise for cancer treatment. By leveraging engineered EcN, we can design a bacteria-assisted, tumor-targeted therapy for t...
Comparative embryogenesis of two salp species reveals rogue development and evolutionary divergence from sessile tunicates [0.03%]
两种盐藻胚胎发育的比较揭示了叛逆发展和与固着式头索动物的进化分歧
Marie Lebel,Alexandre Alié,Patrick Lemaire et al.
Marie Lebel et al.
Tunicates are the closest living relatives of vertebrates. Recent phylogenies place the little-studied, free-swimming thaliaceans-including salps-within sessile ascidians, highlighting a remarkable ecological transition. Historical reports ...
Comparative Study
PLoS biology. 2026 Mar 17;24(3):e3003636. DOI:10.1371/journal.pbio.3003636 2026
Humza N Zubair,Matthias Stangl,Uros Topalovic et al.
Humza N Zubair et al.
Numerous studies across species emphasize the importance of theta oscillations within medial temporal lobe (MTL) regions, such as the hippocampus, in relation to memory. In rodents, physical movement strongly influences theta activity, whil...
Behavioral engagement facilitates auditory neuron responses beyond their receptive fields [0.03%]
行为参与可使听觉神经元在其感受野之外产生反应
Chenggang Chen,Evan D Remington,Xiaoqin Wang
Chenggang Chen
In the auditory cortex, neural responses to stimuli inside receptive fields (RFs) can be further facilitated by behavioral demands, such as attending to a spatial location. It is less clear how off-RF stimuli modulate neural responses and c...
Non-peptide dysbiosis metabolites reprogram a peptide quorum-sensing receptor to induce sustained predation in beneficial streptococci [0.03%]
非肽类菌群失调代谢产物可重编程肽类群体感应受体以诱导有益链球菌产生持续捕食效应
Guillaume Cerckel,Denis Dereinne,Laura Ledesma-García et al.
Guillaume Cerckel et al.
Cytoplasmic receptors of the RRNPPA superfamily mediate peptide-based quorum sensing in Gram-positive bacteria and are thought to be activated exclusively by short, unmodified pheromones. Here, we show that the RRNPPA regulator ComR in the ...