Justin Crocker
Justin Crocker
Wherever we look, insect numbers are declining, but most insect life on Earth is found in locations we are not actively monitoring. The defining task of the next decade will be to build the planetary observatory that biodiversity science re...
Stress granules formed during infections with RNA viruses have significant virus-specific differences in generation and composition [0.03%]
感染RNA病毒时形成的应激颗粒在生成和组成上存在显著的病毒特异性差异
Reto M Lang,Silvio Steiner,Jenna Kelly et al.
Reto M Lang et al.
Eukaryotic cells evolved a cellular stress response to cope with extrinsic and intrinsic stress stimuli including virus infections. The major result of this response is the shutdown of bulk translation to prevent damage and allow the reprog...
Julia B Cordero
Julia B Cordero
How developing animals sense nutritional shortages to adjust growth? A new study in PLOS Biology shows that the developing intestine is a central regulator of animal growth in response to microbiome composition and nutritional deficiency. ...
A nutrient-sensitive enterokine coordinates developmental plasticity through inter-organ signaling [0.03%]
一种营养敏感性肠激素通过器官间信号传导协调发育可塑性
Longwei Bai,Jacques Montagne,Cathy Isaura Ramos et al.
Longwei Bai et al.
Animal survival in fluctuating environments depends on the ability to modulate their developmental pace in response to nutrient availability, a phenomenon known as developmental plasticity. In Drosophila larvae, we uncover a critical endocr...
A microRNA atlas of CD4+ T cell subsets in experimental autoimmune encephalomyelitis identifies regulators of disease pathogenesis [0.03%]
实验性自身免疫性脑脊髓炎中CD4+t细胞亚群的微小rna图谱确定疾病发病机制的调节因子
Carolina Cunha,Daniel Inácio,Paula Vargas Romero et al.
Carolina Cunha et al.
MicroRNAs (miRNAs) are key regulators of CD4+ T cell differentiation, but how they contribute to the course of an autoimmune disease in vivo remains poorly studied. Given the known roles in autoimmunity of pro-inflammatory T helper 1 (Th)1 ...
A microRNA atlas of CD4+ T cell subsets in experimental autoimmune encephalomyelitis identifies regulators of disease pathogenesis [0.03%]
实验性自身免疫性脑脊髓炎中CD4+t细胞亚群的微小rna图谱鉴定出疾病发病机制调节物
Carolina Cunha,Daniel Inácio,Paula Vargas Romero et al.
Carolina Cunha et al.
MicroRNAs (miRNAs) are key regulators of CD4+ T cell differentiation, but how they contribute to the course of an autoimmune disease in vivo remains poorly studied. Given the known roles in autoimmunity of pro-inflammatory T helper 1 (Th)1 ...
Neural encoding of pain is robust within but unstable between individuals [0.03%]
疼痛的神经编码在个体内稳健但在个体间不稳定
Laura Tiemann,Felix S Bott,Elisabeth S May et al.
Laura Tiemann et al.
The perception of pain varies both within and between individuals, even when sensory input remains constant. Understanding how the brain encodes these intra- and inter-individual variations is central to elucidating the neural mechanisms of...
Lateralised neural mechanisms facilitate auditory self-other distinction and coordination in human dyads [0.03%]
侧化的神经机制促进人类双人组的听觉自我-他人区分与协调
Manuel Varlet,Tomas Lenc,Sylvie Nozaradan et al.
Manuel Varlet et al.
Coordinating actions with others is essential for successful social interaction. Such coordination, as in sports and musical performances, often relies on sound, requiring the brain to process and integrate acoustic information related to t...
Asymmetric chromatin accessibility underlies anterior-posterior axis specification in moth fly embryos [0.03%]
moth fly胚胎前后轴规范的非对称染色质可及性基础
Ezra E Amiri,Muzi Li,Ayse Tenger-Trolander et al.
Ezra E Amiri et al.
Establishing the anterior-posterior (AP) body axis is a fundamental process during embryogenesis, and the fruit fly, Drosophila melanogaster, provides one of the best-known case studies. But for unknown reasons, different species of flies (...
Meal timing entrains circadian rhythms in the dorsal vagal complex, a brainstem satiety centre [0.03%]
进食时间同步背迷走神经复合体的昼夜节律，背迷走神经复合体是脑干中的一个饱腹中枢
Lukasz Chrobok,Charlotte Muir,Tanya Chonkria Kaur et al.
Lukasz Chrobok et al.
The dorsal vagal complex (DVC) includes a multi-component brainstem satiety centre which has gained attention as a key target of anti-obesity pharmacotherapies. Our recent studies revealed its circadian timekeeping properties, with molecula...