A single-cell spatiotemporal transcriptomic atlas of mouse prefrontal cortex maps dynamics of intratelencephalic neurons during postnatal development [0.03%]
小鼠前额叶皮层单细胞时空转录图谱揭示了后天发育过程中局灶感觉皮质投射神经元的动态变化规律
Hu Zheng,Keji Yan,Xiaojuan Gou et al.
Hu Zheng et al.
In early postnatal brain, the prefrontal cortex (PFC) remains immature and highly plastic, particularly for the intratelencephalic (IT) neurons. However, the spatiotemporal molecular and cellular dynamics of PFC during this period remain po...
Sensory sharpening and semantic prediction errors unify competing models of predictive processing in human speech comprehension [0.03%]
感官敏锐度和语义预测误差统一了人类言语理解中相互竞争的预言加工模型
Fabian Schneider,Helen Blank
Fabian Schneider
The human brain makes abundant predictions in speech comprehension that, in real-world conversations, depend on conversational partners. Yet, tested models of predictive processing diverge on how such predictions are integrated with incomin...
Multi-omics and perturbation screens as discovery tools in immunometabolism [0.03%]
多组学和扰动筛选在免疫代谢中的发现工具作用
Nicole M Chapman,Hongbo Chi
Nicole M Chapman
Metabolic rewiring of immune cells has broad impacts on immune responses and disease outcomes. Systems biology approaches, such as multi-omics profiling and perturbation screening, could uncover new actionable targets and therapeutic avenue...
Ezio Rosato
Ezio Rosato
The timed release of gametes is an important feature of marine organisms, and in hydrozoan jellyfish is usually controlled by light. A recent study in PLOS Biology reveals an emerging endogenous clock controlling rhythmic egg release in a n...
Bottleneck size drives the evolution of cooperative traits in an aggregative multicellular myxobacterium [0.03%]
瓶颈大小驱动聚集性多细胞黏细菌中合作特征的进化
Jyotsna Kalathera,Prakhar Jaiswal,Neha Mandal et al.
Jyotsna Kalathera et al.
Repeated population bottlenecks influence the evolution and maintenance of cooperation. However, it remains unclear whether bottlenecks select all cooperative traits expressed by an organism or only a subset of them. Myxococcus xanthus, a s...
A light-entrained clock mechanism in a hydrozoan jellyfish synchronizes evening gamete release [0.03%]
水母型水母中受光照调控的时钟机制同步黄昏时刻的配子释放
Ruka Kitsui,Noriyo Takeda,Evelyn Houliston et al.
Ruka Kitsui et al.
For marine species that reproduce by external fertilization, spawning is precisely coordinated within a local population to maximize the chances of producing offspring. Gamete release is often synchronized with respect to the diel light cha...
Temperate phage evolve to integrate host stress and quorum signals in lysis-lysogeny decisions [0.03%]
温和噬菌体进化出整合宿主压力和群体信号在裂解溶源决策中的作用
John B Bruce,Robyn Manley,Elvina Smith et al.
John B Bruce et al.
Temperate phage can transmit both horizontally (lytic cycle) and vertically (lysogenic cycle). Many temperate phage have the ability to modify their lysis/lysogeny decisions based on various environmental cues. For instance, many prophage a...
Characterization of RNA interference in the cnidarian Nematostella vectensis reveals partial target silencing but lack of small RNA amplification [0.03%]
棒胚虫(Nematostella vectensis)的RNA干扰表征揭示了部分靶沉默，但缺乏小RNA放大作用
Yael Admoni,Magda Lewandowska,Reuven Aharoni et al.
Yael Admoni et al.
RNA interference (RNAi) is a sequence-specific mRNA degradation mechanism, in which short interfering RNAs (siRNAs) guide Argonaute proteins to complementary targets, resulting in their degradation. In many organisms, RNAi also serves antiv...
The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice [0.03%]
ARHGEF3通过协调细胞命运和P-钙粘蛋白模式在小鼠中调控毛囊芽的形成
Krithika Kalyanakrishnan,Amy Beaudin,Alexandra Jetté et al.
Krithika Kalyanakrishnan et al.
During embryogenesis, cells self-organize into precise patterns that enable tissues and organs to acquire specialized functions. Despite its importance, the molecular choreography driving these collective cellular behaviors remains poorly u...
MMSpa is a deep learning-based tool that enhances the identification of spatial domains in spatial transcriptomics studies [0.03%]
MMSpa：一种基于深度学习的空间转录组学空间域识别增强工具
Yi Liu,Yixiao Zhai,Pinglu Zhang et al.
Yi Liu et al.
Spatial transcriptome (ST) technologies have transformed the study of tissue structure by retaining the spatial distribution of gene expression. One major challenge in accurately identifying spatial domains is to extract domain-related info...