Transcriptomic analysis of the 12 major human breast cell types reveals mechanisms of cell and tissue function [0.03%]
转录组分析揭示了人类乳腺12种主要细胞类型的细胞和组织功能机制
Katelyn Del Toro,Rosalyn Sayaman,Kate Thi et al.
Katelyn Del Toro et al.
A fundamental question in biology, central to our understanding of cancer and other pathologies, is determining how different cell types coordinate to form and maintain tissues. Recognizing the distinct features and capabilities of the cell...
Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region [0.03%]
基于社区的重建和模拟大鼠海马CA1区域的全尺寸模型
Armando Romani,Alberto Antonietti,Davide Bella et al.
Armando Romani et al.
The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure...
Biomedical researchers' perspectives on the reproducibility of research [0.03%]
biomedical研究人员对科研再现性的看法
Kelly D Cobey,Sanam Ebrahimzadeh,Matthew J Page et al.
Kelly D Cobey et al.
We conducted an international cross-sectional survey of biomedical researchers' perspectives on the reproducibility of research. This study builds on a widely cited 2016 survey on reproducibility and provides a biomedical-specific and conte...
Harnessing plant biosynthesis for the development of next-generation therapeutics [0.03%]
利用植物生物合成开发下一代药物治疗方案
Philip Spence,James Reed,Anne Osbourn
Philip Spence
Genomics-based predictions indicate that plants harbor the ability to make a vast array of as yet undiscovered chemistry. Recent advances open up the potential to harness this capability at unprecedented scale for the discovery and developm...
Climate and ecology predict latitudinal trends in sexual selection inferred from avian mating systems [0.03%]
气候和生态预测了由鸟类交配系统推断出的性选择纬度变化趋势
Robert A Barber,Jingyi Yang,Chenyue Yang et al.
Robert A Barber et al.
Sexual selection, one of the central pillars of evolutionary theory, has powerful effects on organismal morphology, behaviour, and population dynamics. However, current knowledge about geographical variation in this evolutionary mechanism a...
Apoptotic extracellular vesicles carrying Mif regulate macrophage recruitment and compensatory proliferation in neighboring epithelial stem cells during tissue maintenance [0.03%]
凋亡小胞通过携带Mif调节组织稳态下巨噬细胞募集和邻近上皮干细胞的代偿增殖
Safia A Essien,Ivanshi Ahuja,George T Eisenhoffer
Safia A Essien
Apoptotic cells can signal to neighboring cells to stimulate proliferation and compensate for cell loss to maintain tissue homeostasis. While apoptotic cell-derived extracellular vesicles (AEVs) can transmit instructional cues to mediate co...
Amyloid accelerator polyphosphate fits as the mystery density in α-synuclein fibrils [0.03%]
多磷酸盐作为α-突触核蛋白原纤维中的神秘密度促进淀粉样加速剂
Philipp Huettemann,Pavithra Mahadevan,Justine Lempart et al.
Philipp Huettemann et al.
Aberrant aggregation of α-Synuclein is the pathological hallmark of a set of neurodegenerative diseases termed synucleinopathies. Recent advances in cryo-electron microscopy have led to the structural determination of the first synucleinop...
Microglia cannibalism during neurodevelopment results in necroptotic cell death [0.03%]
小胶质细胞在神经发育期间的食我作用导致坏死性细胞死亡
F Chris Bennett,Mariko L Bennett
F Chris Bennett
Clearance of dying neurons by microglia is critical to healthy neurodevelopment, but what else do microglia eat? A new study in PLOS Biology demonstrates that microglia not only eat neurons but each other, and that this "microglia cannibali...
Ortholog of autism candidate gene RBM27 regulates mitoribosomal assembly factor MALS-1 to protect against mitochondrial dysfunction and axon degeneration during neurodevelopment [0.03%]
自闭症候选基因RBM27的ortholog通过调节线粒体核糖体装配因子MALS-1在线神经发生过程中抵抗线粒体功能障碍和轴突变性
Tamjid A Chowdhury,David A Luy,Garrett Scapellato et al.
Tamjid A Chowdhury et al.
Mitochondrial dysfunction is thought to be a key component of neurodevelopmental disorders such as autism, intellectual disability, and attention-deficit hyperactivity disorder (ADHD). However, little is known about the molecular mechanisms...
A multichannel electrophysiological approach to noninvasively and precisely record human spinal cord activity [0.03%]
一种多通道电生理方法，可非侵入性地精确记录人类脊髓活动
Birgit Nierula,Tilman Stephani,Emma Bailey et al.
Birgit Nierula et al.
The spinal cord is of fundamental importance for integrative processing in brain-body communication, yet routine noninvasive recordings in humans are hindered by vast methodological challenges. Here, we overcome these challenges by developi...