Organ transformation by environmental disruption of protein integrity and epigenetic memory in Drosophila [0.03%]
环境干扰蛋白质稳定性和表观遗传记忆改变果蝇器官功能转换
Orli Snir,Michael Elgart,Yulia Gnainsky et al.
Orli Snir et al.
Despite significant progress in understanding epigenetic reprogramming of cells, the mechanistic basis of "organ reprogramming" by (epi-)gene-environment interactions remained largely obscure. Here, we use the ether-induced haltere-to-wing ...
Roland G Roberts;PLOS Biology staff editors
Roland G Roberts;PLOS Biology staff editors
The phylogenetic tree has been a core conceptual tool for evolutionary biology for nearly 200 years. This editorial explores the role of the tree as a metaphor, discussing two new PLOS Biology Essays that look to the future. ...
Male allocation to ejaculation and mating effort imposes different life history trade-offs [0.03%]
精子竞争和求偶对雄性生活史产生的不同影响
Meng-Han Joseph Chung,Rebecca J Fox,Michael D Jennions
Meng-Han Joseph Chung
When males compete, sexual selection favors reproductive traits that increase their mating or fertilization success (pre- and postcopulatory sexual selection). It is assumed that males face a trade-off between these 2 types of sexual traits...
Integrating phylogenies into single-cell RNA sequencing analysis allows comparisons across species, genes, and cells [0.03%]
整合系统发育树的单细胞RNA测序分析可实现跨物种、基因和细胞的比较
Samuel H Church,Jasmine L Mah,Casey W Dunn
Samuel H Church
Comparisons of single-cell RNA sequencing (scRNA-seq) data across species can reveal links between cellular gene expression and the evolution of cell functions, features, and phenotypes. These comparisons evoke evolutionary histories, as de...
Comparative Study
PLoS biology. 2024 May 24;22(5):e3002633. DOI:10.1371/journal.pbio.3002633 2024
Assessing the evolution of research topics in a biological field using plant science as an example [0.03%]
以植物科学为例评估生物学领域研究主题的发展演变
Shin-Han Shiu,Melissa D Lehti-Shiu
Shin-Han Shiu
Scientific advances due to conceptual or technological innovations can be revealed by examining how research topics have evolved. But such topical evolution is difficult to uncover and quantify because of the large body of literature and th...
Yersinia pestis can infect the Pawlowsky glands of human body lice and be transmitted by louse bite [0.03%]
耶氏鼠疫菌能够感染体虱的帕沃尔斯基氏腺并通过叮咬传播给宿主
David M Bland,Dan Long,Rebecca Rosenke et al.
David M Bland et al.
Yersinia pestis, the causative agent of plague, is a highly lethal vector-borne pathogen responsible for killing large portions of Europe's population during the Black Death of the Middle Ages. In the wild, Y. pestis cycles between fleas an...
Scaling up area-based conservation to implement the Global Biodiversity Framework's 30x30 target: The role of Nature's Strongholds [0.03%]
扩大基于区域的保护以实施全球生物多样性框架的30×30目标：自然保护区的作用
John G Robinson,Danielle LaBruna,Tim O&#x;Brien et al.
John G Robinson et al.
The Global Biodiversity Framework (GBF), signed in 2022 by Parties to the Convention on Biological Diversity, recognized the importance of area-based conservation, and its goals and targets specify the characteristics of protected and conse...
Jacob L Steenwyk,Nicole King
Jacob L Steenwyk
Reconstructing the tree of life remains a central goal in biology. Early methods, which relied on small numbers of morphological or genetic characters, often yielded conflicting evolutionary histories, undermining confidence in the results....
Simple visual stimuli are sufficient to drive responses in action observation and execution neurons in macaque ventral premotor cortex [0.03%]
简单的视觉刺激足以驱动猕猴腹侧运动前区动作观察和执行神经元的反应
Sofie De Schrijver,Thomas Decramer,Peter Janssen
Sofie De Schrijver
Neurons responding during action execution and action observation were discovered in the ventral premotor cortex 3 decades ago. However, the visual features that drive the responses of action observation/execution neurons (AOENs) have not b...
Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation [0.03%]
茋类OXINDOLE是新型PROTAC构件可募集CRL4-DCAF11E3泛素连接酶复合物降解靶蛋白
Ying Wang,Tianzi Wei,Man Zhao et al.
Ying Wang et al.
Alkenyl oxindoles have been characterized as autophagosome-tethering compounds (ATTECs), which can target mutant huntingtin protein (mHTT) for lysosomal degradation. In order to expand the application of alkenyl oxindoles for targeted prote...