Learning engages transient and sustained cellular mechanisms in the human brain [0.03%]
学习在人脑中启动短暂和持续的细胞机制
Guillermina Griffa,Marco Palombo,Abraham Yeffal et al.
Guillermina Griffa et al.
Structural neuroplasticity supports learning, development, and shapes vulnerability to brain disorders, making it a central priority in neuroscience research. However, progress in humans has remained limited by the inability to probe cellul...
Argonaute 2 drives resistance to immune checkpoint inhibitors in immunorefractory non-small cell lung cancer [0.03%]
Argonaute 2介导非小细胞肺癌免疫治疗耐药性机制研究
Dario Pasquale Anobile,Layla Barbar,Emile Maucotel et al.
Dario Pasquale Anobile et al.
One of the first-line treatments for advanced non-small cell lung cancer (NSCLC) are immune checkpoint inhibitors (ICI), which activate the antitumor immune response. Despite their success, ICI remain ineffective in many patients, highlight...
The microglia-derived protein sema4ab attenuates regenerative neurogenesis after spinal cord injury in zebrafish [0.03%]
来源于小胶质细胞的蛋白sema4ab通过抑制脊髓损伤后的再生性神经发生促进斑马鱼脊髓损伤修复
Alberto Docampo-Seara,Mehmet Ilyas Cosacak,Kim Heilemann et al.
Alberto Docampo-Seara et al.
Zebrafish, in contrast to mammals, regenerate neurons after spinal cord injury, but little is known about the control mechanisms of this process. Here we use scRNA-seq and in vivo experiments to show that sema4ab, mainly expressed by lesion...
Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction [0.03%]
载脂蛋白在热量限制期间对脂质、氨基酸和葡萄糖代谢产生性别差异性影响
Yoshiko M Ikushima,Kuan-Chan Chen,Richard J Sulston et al.
Yoshiko M Ikushima et al.
Adiponectin is the most abundant hormone in the circulation. Plasma adiponectin decreases in obesity but increases in leanness, including during caloric restriction (CR) in animals and humans. In obesity, adiponectin deficiency promotes car...
Lillith C Zijmers,Katie L Abson,Jarrod D Hadfield et al.
Lillith C Zijmers et al.
A population's ability to adapt is determined by its levels of additive genetic variance (VA), and while it is agreed that most organisms have genetic variation for most traits, the extent to which it varies between species is poorly charac...
Marlis Reich
Marlis Reich
Marine fungi were assumed to have a minor role in carbon cycling, unable to compete with bacteria. A new PLOS Biology study challenges this dogma, showing fungi can dominate labile dissolved organic matter assimilation, reshaping our unders...
Ubiquitin-proteasome system regulates pro-crossover protein dynamics during meiosis in Caenorhabditis elegans [0.03%]
泛素-蛋白酶体系统调控秀丽隐杆线虫减数分裂期间促交换蛋白质的动态变化
Hongtao Zhang,Wenqing Liang,Meng Li et al.
Hongtao Zhang et al.
Crossover (CO) formation ensures accurate segregation of homologous chromosomes during the first meiotic division. The pro-crossover proteins are essential for crossover formation and undergo dynamic changes during meiotic prophase I, altho...
Juan Carlos Trejos-Espeleta,James A Bradley,Ömer K Coskun et al.
Juan Carlos Trejos-Espeleta et al.
Fungi serve as critical biological carbon storage reservoirs in soil ecosystems, but whether this fungal trait is also important for marine sediment carbon storage processes is poorly understood. Here, we quantify for the first time assimil...
Asa Farahani,Zhen-Qi Liu,Filip Morys et al.
Asa Farahani et al.
The brain and body undergo coordinated changes throughout the life span, yet studies of aging have traditionally examined these systems as separate entities. Here we ask how brain health relates to aging and peripheral biomarkers of metabol...
Evolutionary analysis of transcription elongation factors reveals conserved and lineage-specific regulatory domains [0.03%]
转录延长因子的进化分析揭示了保守和谱系特异性的调控结构域
Alex M Francette,Aakash Grover,Nathan Clark et al.
Alex M Francette et al.
In eukaryotes, transcription elongation factors (TEFs) associate with RNA Polymerase II (RNAPII) to facilitate gene expression and couple transcription to co-transcriptional processes, including chromatin regulation and RNA processing. To f...