The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model [0.03%]
脂代谢酶HSD17B12通过溶酶体途径降解PD-L1促进小鼠模型中的抗肿瘤免疫反应
Zhihui Zhou,Ying Lu,Pan Li et al.
Zhihui Zhou et al.
The high prevalence of cancer immunotherapy resistance, coupled with substantial tumor heterogeneity, underscores the urgent need for innovative therapeutic targets. A deeper understanding of immunoregulatory mechanisms would provide new ta...
Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells [0.03%]
I型和III型干扰素以剂量依赖的方式激活Hippo通路并抑制人支气管上皮细胞的组织修复功能
Krupakar V Subramaniam,Hui Jing Lim,Bao Wang et al.
Krupakar V Subramaniam et al.
Interferons (IFNs) are potent antiviral cytokines that are rapidly activated when infected cells sense a virus, but continued IFN production following acute infection is linked to impaired recovery. IFNs protect against infection by inducin...
Overexpression of the pioneer transcription factor Nr5a2 promotes the development of mouse somatic cell nuclear transfer embryos [0.03%]
先驱转录因子Nr5a2的过表达促进体细胞核移植胚胎发育
Yanhua Zhao,Meiting Zhang,Yan You et al.
Yanhua Zhao et al.
Somatic cell nuclear transfer (SCNT) is a valuable tool in regenerative medicine, yet its efficiency remains limited by epigenetic reprogramming barriers that have been partially corrected by global regulation of epigenetic enzymes. However...
The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development [0.03%]
Mitochondrial外膜蛋白Mtch在果蝇肠发育中的线粒体自噬中的调控作用
Lucas J Restrepo,Jasmine K Graslie,Tina M Fortier et al.
Lucas J Restrepo et al.
The clearance of mitochondria by autophagy (mitophagy) is important for cell health. Mutations in genes that are required for mitophagy, including Vps13D, PINK1, and Parkin, are associated with movement disorders, but gaps exist in our unde...
Dynamic auxin maxima regulate male-to-hermaphrodite conversion and de novo meristem formation in the fern Ceratopteris gametophytes [0.03%]
动态生长素峰值调节拟齿缘波叶草雄性配子体向两性合子体的转换及新分生组织的发生
Dinh Nhan Lai,Xi Yang,Chong Xie et al.
Dinh Nhan Lai et al.
Land plants alternate between generations of asexual sporophytes and sexual gametophytes. Unlike seed plants, ferns produce free-living gametophytes that grow independently from their sporophytes. Gametophytes of the model fern Ceratopteris...
Optineurin binding to the novel interacting partner Junction plakoglobin prevents muscle atrophy in mice [0.03%]
.optineurin与新型相互作用蛋白连接斑蛋白结合可防止小鼠肌肉萎缩
Xiao Chen Shi,Rui Xin Zhang,Jun Kai Feng et al.
Xiao Chen Shi et al.
Skeletal muscle atrophy is a debilitating condition that significantly affects patients' quality of life and prognosis, yet its underlying mechanisms remain poorly understood. Here, we identify Optineurin (OPTN) as an active regulator for m...
Experimental evidence that penis size, height, and body shape influence assessment of male sexual attractiveness and fighting ability in humans [0.03%]
实验证据表明，阴茎大小、身高和体型影响人类对男性性吸引力和战斗力的评估
Upama Aich,Chloe Tan,Rebecca Bathgate et al.
Upama Aich et al.
Why the human penis is unusually large compared to that of other primates is a long-standing evolutionary question. Sexual selection, through female mate choice and male-male competition, is a likely driver, but confirming this is difficult...
Immunometabolism in obesity: Understanding the beneficial and detrimental roles of inflammation [0.03%]
肥胖免疫代谢：理解炎症的有益和有害作用
Yun Sok Lee
Yun Sok Lee
In obesity, nutrient excess and altered adipocyte secretory profiles reprogram cell-intrinsic metabolism, leading to the activation of immune cells within metabolically active tissues such as adipose tissue. This obesity-associated chronic ...
Pangenome graph analysis reveals evolution of resistance breaking in spinach downy mildew [0.03%]
泛基因组图谱分析揭示了菠菜白粉病菌抗性突破的进化规律
Petros Skiadas,Melanie N Mendel,Joyce Elberse et al.
Petros Skiadas et al.
Filamentous plant pathogens secrete effectors to successfully establish host infections. In resistant crop varieties, plant immunity can be triggered by immune receptors that recognize these effectors. Resistant crop varieties are grown in ...
Komal Panchal Suthar,Caitlin Hounsell,Yun Fan et al.
Komal Panchal Suthar et al.
Caspases, traditionally viewed as mediators of apoptosis and tumor suppressors, have also been shown to promote cell proliferation and to contribute to tumor growth. For example, the initiator caspase Dronc (the Drosophila orthologue of Cas...