The Activation Mechanism of the Insulin Receptor: A Structural Perspective [0.03%]
从结构角度解析胰岛素受体的激活机制
Eunhee Choi,Xiao-Chen Bai
Eunhee Choi
The insulin receptor (IR) is a type II receptor tyrosine kinase that plays essential roles in metabolism, growth, and proliferation. Dysregulation of IR signaling is linked to many human diseases, such as diabetes and cancers. The resolutio...
The Inseparable Relationship Between Cholesterol and Hedgehog Signaling [0.03%]
胆固醇与Hedgehog信号通路的相互关系研究
Christian Siebold,Rajat Rohatgi
Christian Siebold
Ligands of the Hedgehog (HH) pathway are paracrine signaling molecules that coordinate tissue development in metazoans. A remarkable feature of HH signaling is the repeated use of cholesterol in steps spanning ligand biogenesis, secretion, ...
Qiushuang Wu,Ariel A Bazzini
Qiushuang Wu
Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the post-transcriptional process that profoundly impact protein production in a cell. While it is widely known that ribosomes produce proteins, studies d...
In Vitro Genetic Code Reprogramming for the Expansion of Usable Noncanonical Amino Acids [0.03%]
体外重编程遗传密码用于扩展非标准氨基酸的使用范围
Takayuki Katoh,Hiroaki Suga
Takayuki Katoh
Genetic code reprogramming has enabled us to ribosomally incorporate various nonproteinogenic amino acids (npAAs) into peptides in vitro. The repertoire of usable npAAs has been expanded to include not only l-α-amino acids with noncanonica...
The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function [0.03%]
SARS-CoV-2细胞内生命周期：复制转录复合体的组装与功能
Zhiyong Lou,Zihe Rao
Zhiyong Lou
The persistence of the coronavirus disease 2019 (COVID-19) pandemic has resulted in increasingly disruptive impacts, and it has become the most devastating challenge to global health in a century. The rapid emergence of severe acute respira...
Nimrod Golan,Yizhaq Engelberg,Meytal Landau
Nimrod Golan
The remarkable variety of microbial species of human pathogens and microbiomes generates significant quantities of secreted amyloids, which are structured protein fibrils that serve diverse functions related to virulence and interactions wi...
Victoria Vu,Magdalena M Szewczyk,David Y Nie et al.
Victoria Vu et al.
Small molecule chemical probes are valuable tools for interrogating protein biological functions and relevance as a therapeutic target. Rigorous validation of chemical probe parameters such as cellular potency and selectivity is critical to...
Kinetic Proofreading [0.03%]
动力学校验机制
Hinrich Boeger
Hinrich Boeger
Biochemistry and molecular biology rely on the recognition of structural complementarity between molecules. Molecular interactions must be both quickly reversible, i.e., tenuous, and specific. How the cell reconciles these conflicting deman...
Alessandro Costa,John F X Diffley
Alessandro Costa
DNA replication in eukaryotic cells initiates from large numbers of sites called replication origins. Initiation of replication from these origins must be tightly controlled to ensure the entire genome is precisely duplicated in each cell c...
Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory [0.03%]
从大自然和实验室中学习E3连接酶底物特异性调控的原理以实现精准靶向降解蛋白质的技术
Angus D Cowan,Alessio Ciulli
Angus D Cowan
Methods to direct the degradation of protein targets with proximity-inducing molecules that coopt the cellular degradation machinery are advancing in leaps and bounds, and diverse modalities are emerging. The most used and well-studied appr...