Hyunji Lee,Wilfred A van der Donk
Hyunji Lee
The past decade has seen impressive advances in understanding the biosynthesis of ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most common modifications found in these natural products is macrocycliz...
Influence of Nonspecific Interactions on Protein Associations: Implications for Biochemistry In Vivo [0.03%]
非特异性作用对蛋白质关联的影响：活体生化意义
Germán Rivas,Allen P Minton
Germán Rivas
The cellular interior is composed of a variety of microenvironments defined by distinct local compositions and composition-dependent intermolecular interactions. We review the various types of nonspecific interactions between proteins and b...
Ramanujan S Hegde
Ramanujan S Hegde
The endoplasmic reticulum (ER) is the site of membrane protein insertion, folding, and assembly in eukaryotes. Over the past few years, a combination of genetic and biochemical studies have implicated an abundant factor termed the ER membra...
Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS-cGAMP-STING Pathway [0.03%]
cGAS-cGAMP-STING通路的先天免疫生化、细胞生物学及病理生理学
Christopher Ritchie,Jacqueline A Carozza,Lingyin Li
Christopher Ritchie
In the decade since the discovery of the innate immune cyclic GMP-AMP synthase (cGAS)-2'3'-cyclic GMP-AMP (cGAMP)-stimulator of interferon genes (STING) pathway, its proper activation and dysregulation have been rapidly implicated in many a...
Melinda M Diver,John V Lin King,David Julius et al.
Melinda M Diver et al.
Transient receptor potential (TRP) ion channels are sophisticated signaling machines that detect a wide variety of environmental and physiological signals. Every cell in the body expresses one or more members of the extended TRP channel fam...
Andrei A Korostelev
Andrei A Korostelev
Accurate protein synthesis (translation) relies on translation factors that rectify ribosome fluctuations into a unidirectional process. Understanding this process requires structural characterization of the ribosome and translation-factor ...
Hyun-Kyu Choi,Hyun Gyu Kim,Min Ju Shon et al.
Hyun-Kyu Choi et al.
Single-molecule magnetic tweezers deliver magnetic force and torque to single target molecules, permitting the study of dynamic changes in biomolecular structures and their interactions. Because the magnetic tweezer setups can generate magn...
Role of the TOM Complex in Protein Import into Mitochondria: Structural Views [0.03%]
蛋白导入线粒体中TOM复合体的作用：结构观点
Yuhei Araiso,Kenichiro Imai,Toshiya Endo
Yuhei Araiso
Mitochondria are central to energy production, metabolism and signaling, and apoptosis. To make new mitochondria from preexisting mitochondria, the cell needs to import mitochondrial proteins from the cytosol into the mitochondria with the ...
Ribonucleotide Incorporation by Eukaryotic B-Family Replicases and Its Implications for Genome Stability [0.03%]
欧氏B家族复制酶掺入核糖核苷酸及其对基因组稳定性的影响
Jessica S Williams,Thomas A Kunkel
Jessica S Williams
Our current view of how DNA-based genomes are efficiently and accurately replicated continues to evolve as new details emerge on the presence of ribonucleotides in DNA. Ribonucleotides are incorporated during eukaryotic DNA replication at r...
Evolutionary Dynamics and Molecular Mechanisms of HORMA Domain Protein Signaling [0.03%]
HORMA结构域蛋白信号转导的进化动态和分子机制研究进展
Yajie Gu,Arshad Desai,Kevin D Corbett
Yajie Gu
Controlled assembly and disassembly of multi-protein complexes is central to cellular signaling. Proteins of the widespread and functionally diverse HORMA family nucleate assembly of signaling complexes by binding short peptide motifs throu...