Luke A Yates,Xiaodong Zhang,Peter M Burgers
Luke A Yates
DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to elicit these checkpoints can lead to genomi...
Nihal Altan-Bonnet,Mamata Panigrahi
Nihal Altan-Bonnet
Viruses must egress from the cells in which they have replicated to spread and propagate. Historically, viruses have been classified into enveloped and nonenveloped forms: Enveloped viruses exploit cellular membrane-trafficking pathways to ...
Inhibiting Lipopolysaccharide Biogenesis: The More You Know the Further You Go [0.03%]
知之愈多，前路愈远——抑制脂多糖生物合成研究
Caitlin B Moffatt,Bailey A Plaman,Sebastian J Rowe et al.
Caitlin B Moffatt et al.
Gram-negative bacteria are intrinsically resistant to many antibiotics because they are surrounded by an outer membrane that creates a robust permeability barrier. The outer membrane has an unusual asymmetric structure with a periplasmic le...
Paul J Lehner
Paul J Lehner
Retroviral and retrotransposon invasion pose a constant threat to genome integrity and have driven the evolution of host defense pathways able to counter these attacks. The human silencing hub (HUSH complex) is an epigenetic transcriptional...
Eukaryotic Microproteins [0.03%]
真核微生物蛋白
Nadiya Jaunbocus,Valerie Ebenki,Haomiao Su et al.
Nadiya Jaunbocus et al.
Microproteins are polypeptides of 100-150 amino acids or fewer that have not been annotated by genome annotation consortia, given their small size and other noncanonical properties. Translated microproteins are now known to number in the th...
Robert V Farese,Tobias C Walther
Robert V Farese
Lipid droplets (LDs), long overlooked as inert cellular storage organelles, are now recognized for their complex and rich biology as membraneless organelles integral to cell metabolism. Significant advances have revealed that LDs are crucia...
Scott B Hansen
Scott B Hansen
Anesthetics are a chemically diverse collection of molecules that dictate neuronal excitability and form the basis of modern medicine. Their molecular mechanism of action is fundamental to understanding nerve excitability, mood, consciousne...
Chih-Hsiang Yang,Oliver J Rando
Chih-Hsiang Yang
Once considered heretical, the idea that environmental conditions experienced in one generation can influence traits in future generations is now increasingly accepted. In particular, hundreds of studies in mammals have documented effects o...
Vivek B Raina,Aidan Jessop,Eric C Greene
Vivek B Raina
Genetic recombination involves the exchange of genetic material between homologous sequences of DNA. It is employed during meiosis in sexually reproducing organisms or in somatic cells to accurately repair toxic DNA lesions like double-stra...
Sarah R Pope,Molly J McBride,Mrutyunjay A Nair et al.
Sarah R Pope et al.
Heme oxygenase (HO)-like metalloenzymes are an emerging protein superfamily diverse in reaction outcome and mechanism. Found primarily in bacterial biosynthetic pathways, members conserve a flexible protein scaffold shared with the heme cat...