Nucleocytoplasmic Transport [0.03%]
George W Mobbs,Stefan Petrovic,André Hoelz
George W Mobbs
Compartmentalization of the genome within the nucleus of eukaryotic cells emerged alongside a two-component molecular machinery for selective transport of macromolecules: a static yet conformationally flexible channel formed by the ∼120-MD...
Rees F Garmann,William M Gelbart
Rees F Garmann
Our double-stranded DNA (dsDNA) genomes are famously compacted by proteins in the nuclei of our cells, resulting in meters of dsDNA being confined in micron-sized volumes. The most prevalent form of viral genomes, however, is single-strande...
Victoria A Federico,David E Cliffel,Jennifer A Gaddy et al.
Victoria A Federico et al.
The gut microbiome governs aspects of human growth and development. While human milk's primary purpose is metabolism, it also provides nonnutritious biologics and macromolecules. This mixture includes the human milk oligosaccharides (HMOs),...
Ashok R Venkitaraman
Ashok R Venkitaraman
Cancer cells acquire hallmark behaviors through adaptations that extend beyond genetic and epigenetic changes. Proteostasis-the biochemical network governing protein synthesis, folding, trafficking, and degradation-is a fundamental, yet und...
Mary O&#x;Reilly,JoAnne Stubbe
Mary O&#x;Reilly
Massachusetts Institute of Technology Professor Emerita JoAnne Stubbe was the chair of Mary O'Reilly's thesis committee. Over a decade later, they became neighbors, and then a global pandemic made them friends. Here they attempt to summariz...
From Cancer, Malate-Aspartate Shuttle, RNA Replicase, and mtDNA to Trypanosomes and Back to Cancer Again [0.03%]
Piet Borst
Piet Borst
I studied medicine to become an endocrinologist but ended up in biochemistry. As a graduate student, I studied tumor mitochondria and discovered the malate-aspartate shuttle (the major route in animal cells for shuttling reducing equivalent...
Radical Chemistry in Metalloenzymes: Bridging Inorganic Centers and Biological Catalysis [0.03%]
金属酶中的自由基化学：无机中心与生物催化之间的桥梁
Maximilian Böhm,Fikret Mamedov,Gustav Berggren et al.
Maximilian Böhm et al.
Radical chemistry, once deemed too reactive for biological systems, is delicately controlled within metalloenzymes to catalyze challenging chemical transformations under physiological conditions. This review explores the diverse strategies ...
Alina Guna,Vy N Nguyen,Taylor A Stevens et al.
Alina Guna et al.
Integral membrane proteins play critical roles in mammalian cells, ranging from mediating cell-cell interactions to regulating apoptosis. These increasingly diverse functions necessitated the evolution of membrane proteins with more complex...
Endogenous Sources of Abasic Sites and Implications for DNA Replication: Mechanisms of Fork Stalling and Recovery [0.03%]
内源性 AP 网点的来源及其对DNA复制的影响：叉停滞与修复机制
Angelo Taglialatela,Alberto Ciccia
Angelo Taglialatela
Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to DNA replication fork progression, lack ...
James H Hurley
James H Hurley
The autophagy core machinery carries out the fundamental reactions of autophagosome biogenesis across all forms of bulk and selective macroautophagy. In humans, the core complexes consist of the ULK1 complex (ULK1C), the class III phosphati...