Anthony M Pedley,Vidhi Pareek,Stephen J Benkovic
Anthony M Pedley
Over the past fifteen years, we have unveiled a new mechanism by which cells achieve greater efficiency in de novo purine biosynthesis. This mechanism relies on the compartmentalization of de novo purine biosynthetic enzymes into a dynamic ...
Eugene Y D Chua,Joshua H Mendez,Micah Rapp et al.
Eugene Y D Chua et al.
Cryo-electron microscopy (cryo-EM) continues its remarkable growth as a method for visualizing biological objects, which has been driven by advances across the entire pipeline. Developments in both single-particle analysis and in situ tomog...
Ellen Youngsoo Rim,Hans Clevers,Roel Nusse
Ellen Youngsoo Rim
The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regul...
Ying Zhou,Hongyan Li,Hongzhe Sun
Ying Zhou
Metals are essential components in life processes and participate in many important biological processes. Dysregulation of metal homeostasis is correlated with many diseases. Metals are also frequently incorporated into diagnosis and therap...
Encapsulins [0.03%]
包涵体蛋白壳层蛋白质
Tobias W Giessen
Tobias W Giessen
Subcellular compartmentalization is a defining feature of all cells. In prokaryotes, compartmentalization is generally achieved via protein-based strategies. The two main classes of microbial protein compartments are bacterial microcompartm...
Pedro Weickert,Julian Stingele
Pedro Weickert
Covalent DNA-protein crosslinks (DPCs) are pervasive DNA lesions that interfere with essential chromatin processes such as transcription or replication. This review strives to provide an overview of the sources and principles of cellular DP...
Kami Ahmad,Steven Henikoff,Srinivas Ramachandran
Kami Ahmad
Gene regulation arises out of dynamic competition between nucleosomes, transcription factors, and other chromatin proteins for the opportunity to bind genomic DNA. The timescales of nucleosome assembly and binding of factors to DNA determin...
The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA-Protein Condensates [0.03%]
DEAD盒ATP酶在基因表达和RNA蛋白凝聚物调控中的作用
Karsten Weis,Maria Hondele
Karsten Weis
DEAD-box ATPases constitute a very large protein family present in all cells, often in great abundance. From bacteria to humans, they play critical roles in many aspects of RNA metabolism, and due to their widespread importance in RNA biolo...
Natalia Ronkina,Matthias Gaestel
Natalia Ronkina
Mitogen-activated protein kinase (MAPK)-activated protein kinases (MAPKAPKs) are defined by their exclusive activation by MAPKs. They can be activated by classical and atypical MAPKs that have been stimulated by mitogens and various stresse...
Lipoproteins in the Central Nervous System: From Biology to Pathobiology [0.03%]
中枢神经系统的脂蛋白：从生物学至病理学
Ana-Caroline Raulin,Yuka A Martens,Guojun Bu
Ana-Caroline Raulin
The brain, as one of the most lipid-rich organs, heavily relies on lipid transport and distribution to maintain homeostasis and neuronal function. Lipid transport mediated by lipoprotein particles, which are complex structures composed of a...