Karin M Reinisch,Pietro De Camilli,Thomas J Melia
Karin M Reinisch
In eukaryotes, lipid building blocks for cellular membranes are made largely in the endoplasmic reticulum and then redistributed to other organelles. Lipids are transported between organelles by vesicular trafficking or else by proteins loc...
Ari Rappoport
Ari Rappoport
I present a theory of Alzheimer's disease (AD) that explains its symptoms, pathology, and risk factors. To do this, I introduce a new theory of brain plasticity that elucidates the physiological roles of AD-related agents. New events genera...
Latika Nagpal,Sining He,Feng Rao et al.
Latika Nagpal et al.
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling metabolites whose versatile modes of action are being increasingly appreciated. These include their emerging roles as energy regulators, phosphodonors, steri...
Arnaud Vanden Broeck,Sebastian Klinge
Arnaud Vanden Broeck
During the last ten years, developments in cryo-electron microscopy have transformed our understanding of eukaryotic ribosome assembly. As a result, the field has advanced from a list of the vast array of ribosome assembly factors toward an...
Noortje de Haan,Mathias I Nielsen,Hans H Wandall
Noortje de Haan
Alexander M Soohoo,Dillon P Cogan,Krystal L Brodsky et al.
Alexander M Soohoo et al.
Three decades of studies on the multifunctional 6-deoxyerythronolide B synthase have laid a foundation for understanding the chemistry and evolution of polyketide antibiotic biosynthesis by a large family of versatile enzymatic assembly lin...
Amanda L Peiffer,A E Dugan,L L Kiessling
Amanda L Peiffer
Human lectins are integral to maintaining microbial homeostasis on the skin, in the blood, and at mucosal barriers. These proteins can recognize microbial glycans and inform the host about its microbial status. In accordance with their role...
Triumphs and Challenges of Natural Product Discovery in the Postgenomic Era [0.03%]
后基因组时代天然产物发现的机遇与挑战
Carolina Cano-Prieto,Agustina Undabarrena,Ana Calheiros de Carvalho et al.
Carolina Cano-Prieto et al.
Natural products have played significant roles as medicine and food throughout human history. Here, we first provide a brief historical overview of natural products, their classification, biosynthetic origins, and the microbiological and ge...
Dario R Alessi,Suzanne R Pfeffer
Dario R Alessi
Activating mutations in leucine-rich repeat kinase 2 (LRRK2) represent the most common cause of monogenic Parkinson's disease. LRRK2 is a large multidomain protein kinase that phosphorylates a specific subset of the ∼65 human Rab GTPases, ...
Harald W Platta,Julia Jeske,Nadine Schmidt et al.
Harald W Platta et al.
Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal (PTS) receptors is an ATP-dependent mechanism. However, the en...