Meagan N Esbin,Trinity Cookis,Sathvik Anantakrishnan et al.
Meagan N Esbin et al.
Gene expression is essential for life and development, allowing the cell to modulate mRNA production in response to intrinsic and extracellular cues. Initiation of gene transcription requires a highly regulated molecular process to assemble...
Endothelial Glycocalyx Turnover in Vascular Health and Disease: Rethinking Endothelial Dysfunction [0.03%]
血管健康与疾病中的内皮糖萼更新：重新审视内皮功能障碍
Alejandro Gomez Toledo,Gregory J Golden,Richard D Cummings et al.
Alejandro Gomez Toledo et al.
The endothelial glycocalyx, a glycan-rich layer on the luminal surface of endothelial cells lining blood and lymphatic vessels, plays a crucial role in vascular homeostasis by regulating vascular permeability, immune cell trafficking, and v...
Anthony C O&#x;Donnell,James M Berger
Anthony C O&#x;Donnell
Topoisomerases are enzymes responsible for recognizing and resolving superhelical crossings and topological tangles in DNA. Topoisomerases also serve as valuable established targets for numerous clinically used antibacterial and antitumor a...
Sophie A S Lawrence,Andrew Dolan,Maya M Miller et al.
Sophie A S Lawrence et al.
In all living organisms, membrane proteins play a crucial role in governing essential biological functions, such as cellular signaling and molecular transport. These functions rely on intricate interactions with a variety of biomolecules, i...
Nicola Porzberg,Klara Gries,Kai Johnsson
Nicola Porzberg
The visualization and manipulation of proteins in live cells are critical for studying complex biological processes. Self-labeling proteins do so by enabling the specific and covalent attachment of synthetic probes, offering unprecedented f...
Jordan Matthew Ngo,Justin Krish Williams,Congyan Zhang et al.
Jordan Matthew Ngo et al.
Extracellular vesicles (EVs) are secreted, membrane-enclosed particles that have been proposed to play a broad role in intercellular communication. Most often, EVs, by analogy to enveloped viruses, are suggested to fuse to or within a targe...
Emerging Approaches for Studying Lipid Dynamics, Metabolism, and Interactions in Cells [0.03%]
研究细胞中脂质动力学、代谢和相互作用的新方法
Lin Luan,Nathan P Frederick,Jeremy M Baskin
Lin Luan
Lipids are a major class of biological molecules, the primary components of cellular membranes, and critical signaling molecules that regulate cell biology and physiology. Due to their dynamic behavior within membranes, rapid transport betw...
Laura Baranello,Fedor Kouzine,David Levens
Laura Baranello
Under hyperproliferative conditions, escalation of genomic activity provokes high levels of DNA mechanical stress. Cancer cells cope with this stress through topoisomerase activity. Topoisomerases support genome-wide programs, including tho...
Jan A van der Knaap,C Peter Verrijzer
Jan A van der Knaap
Metabolism and gene regulation are vital processes that need to be tightly coordinated to maintain homeostasis or to enable growth and development. Recent research has begun to reveal the surprisingly interlaced relationship between metabol...
Joshua A J Burton,Marcus J Edwards,David J Richardson et al.
Joshua A J Burton et al.
Extracellular electron transfer is an ancient and ubiquitous process that is used by a range of microorganisms to exchange electrons between the cell and environment. These electron transfer reactions can impact the solubility and speciatio...