Current Understanding of the Mechanism of Water Oxidation in Photosystem II and Its Relation to XFEL Data [0.03%]
关于光系统II中水分解机理的当前认识及其与XFEL数据的关系
Nicholas Cox,Dimitrios A Pantazis,Wolfgang Lubitz
Nicholas Cox
The investigation of water oxidation in photosynthesis has remained a central topic in biochemical research for the last few decades due to the importance of this catalytic process for technological applications. Significant progress has be...
Andrew Field,Karen Adelman
Andrew Field
Cell-type- and condition-specific profiles of gene expression require coordination between protein-coding gene promoters and cis-regulatory sequences called enhancers. Enhancers can stimulate gene activity at great genomic distances from th...
Alan R Davidson,Wang-Ting Lu,Sabrina Y Stanley et al.
Alan R Davidson et al.
Clustered regularly interspaced short palindromic repeats (CRISPR) together with their accompanying cas (CRISPR-associated) genes are found frequently in bacteria and archaea, serving to defend against invading foreign DNA, such as viral ge...
David P Waterman,James E Haber,Marcus B Smolka
David P Waterman
Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cell...
Imaging of DNA and RNA in Living Eukaryotic Cells to Reveal Spatiotemporal Dynamics of Gene Expression [0.03%]
活体真核细胞的DNA和RNA成像以揭示基因表达时空动态规律
Hanae Sato,Sulagna Das,Robert H Singer et al.
Hanae Sato et al.
This review focuses on imaging DNA and single RNA molecules in living cells to define eukaryotic functional organization and dynamic processes. The latest advances in technologies to visualize individual DNA loci and RNAs in real time are d...
The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches [0.03%]
肌球蛋白机械酶家族：从机制到治疗策略
Darshan V Trivedi,Suman Nag,Annamma Spudich et al.
Darshan V Trivedi et al.
Myosins are among the most fascinating enzymes in biology. As extremely allosteric chemomechanical molecular machines, myosins are involved in myriad pivotal cellular functions and are frequently sites of mutations leading to disease phenot...
Rebecca M Sebastian,Matthew D Shoulders
Rebecca M Sebastian
Protein folding in the cell is mediated by an extensive network of >1,000 chaperones, quality control factors, and trafficking mechanisms collectively termed the proteostasis network. While the components and organization of this network ar...
Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity [0.03%]
线粒体蛋白酶：调控线粒体可塑性的多功能调节因子
Soni Deshwal,Kai Uwe Fiedler,Thomas Langer
Soni Deshwal
Mitochondria are essential metabolic hubs that dynamically adapt to physiological demands. More than 40 proteases residing in different compartments of mitochondria, termed mitoproteases, preserve mitochondrial proteostasis and are emerging...
Roland Lill,Sven-A Freibert
Roland Lill
Mitochondria are essential in most eukaryotes and are involved in numerous biological functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and steroid metabolism. Work over the past two decades has uncovere...
Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming [0.03%]
Polycomb和Trithorax在转录编程中的动态竞争关系
Mitzi I Kuroda,Hyuckjoon Kang,Sandip De et al.
Mitzi I Kuroda et al.
Predicting regulatory potential from primary DNA sequences or transcription factor binding patterns is not possible. However, the annotation of the genome by chromatin proteins, histone modifications, and differential compaction is largely ...