Daniel R Semlow,Johannes C Walter
Daniel R Semlow
DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer predisposition syndrome, Fanconi anemia, and upregulation ...
A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters [0.03%]
天然产物化学家激活沉默型生物合成基因簇的指南
Brett C Covington,Fei Xu,Mohammad R Seyedsayamdost
Brett C Covington
Microbial natural products have provided an important source of therapeutic leads and motivated research and innovation in diverse scientific disciplines. In recent years, it has become evident that bacteria harbor a large, hidden reservoir...
Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation [0.03%]
哺乳动物丝氨酸和蛋白质赖氨酸酰化的功能研究
Miao Wang,Hening Lin
Miao Wang
Protein lysine acetylation is an important posttranslational modification that regulates numerous biological processes. Targeting lysine acetylation regulatory factors, such as acetyltransferases, deacetylases, and acetyl-lysine recognition...
Yifeng Wei,Yan Zhang
Yifeng Wei
Sulfonates include diverse natural products and anthropogenic chemicals and are widespread in the environment. Many bacteria can degrade sulfonates and obtain sulfur, carbon, and energy for growth, playing important roles in the biogeochemi...
Shinya Ito,Kazuhiro Nagata
Shinya Ito
Collagen is the most abundant protein in mammals. A unique feature of collagen is its triple-helical structure formed by the Gly-Xaa-Yaa repeats. Three single chains of procollagen make a trimer, and the triple-helical structure is then fol...
Yongli Zhang,Frederick M Hughson
Yongli Zhang
SNARE proteins and Sec1/Munc18 (SM) proteins constitute the core molecular engine that drives nearly all intracellular membrane fusion and exocytosis. While SNAREs are known to couple their folding and assembly to membrane fusion, the physi...
Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis [0.03%]
Cullin-RING泛素连接酶调控回路：F-box假说二十五年来的研究进展
J Wade Harper,Brenda A Schulman
J Wade Harper
Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad biological processes through target-specific ubiquitylation. Our knowledge of this system emerged from the F-box hypothesis, posited a quarter century a...
Z W Kockler,B Osia,R Lee et al.
Z W Kockler et al.
Double-strand DNA breaks (DSBs) are the most lethal type of DNA damage, making DSB repair critical for cell survival. However, some DSB repair pathways are mutagenic and promote genome rearrangements, leading to genome destabilization. One ...
Ilan Attali,Michael R Botchan,James M Berger
Ilan Attali
The faithful and timely copying of DNA by molecular machines known as replisomes depends on a disparate suite of enzymes and scaffolding factors working together in a highly orchestrated manner. Large, dynamic protein-nucleic acid assemblie...
Designing Biological Circuits: Synthetic Biology Within the Operon Model and Beyond [0.03%]
生物电路设计——超越操纵子模型的合成生物学
Max A English,Raphaël V Gayet,James J Collins
Max A English
In 1961, Jacob and Monod proposed the operon model of gene regulation. At the model's core was the modular assembly of regulators, operators, and structural genes. To illustrate the composability of these elements, Jacob and Monod linked ph...