Stephen J Benkovic
Stephen J Benkovic
I endeavor to share how various choices-some deliberate, some unconscious-and the unmistakable influence of many others shaped my scientific pursuits. I am fascinated by how two long-term, major streams of my research, DNA replication and p...
Short- and Long-Term Adaptation to Altered Levels of Glucose: Fifty Years of Scientific Adventure [0.03%]
血糖水平变化的短期和长期适应：五十年的科学探索之旅
Kosaku Uyeda
Kosaku Uyeda
My graduate and postdoctoral training in metabolism and enzymology eventually led me to study the short- and long-term regulation of glucose and lipid metabolism. In the early phase of my career, my trainees and I identified, purified, and ...
Gunnar von Heijne
Gunnar von Heijne
This volume of the Annual Review of Biochemistry contains three reviews on membrane channel proteins: the first by Szczot et al., titled The Form and Function of PIEZO2; the second by Ruprecht & Kunji, titled Structural Mechanism of Transpo...
Xuelang Mu,Cody Gillman,Chi Nguyen et al.
Xuelang Mu et al.
The bedrock of drug discovery and a key tool for understanding cellular function and drug mechanisms of action is the structure determination of chemical compounds, peptides, and proteins. The development of new structure characterization t...
Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol [0.03%]
胆固醇合成限速酶HMGCoA还原酶的翻译后调节机制研究进展
Marc M Schumacher,Russell A DeBose-Boyd
Marc M Schumacher
The polytopic, endoplasmic reticulum (ER) membrane protein 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase produces mevalonate, the key intermediate in the synthesis of cholesterol and many nonsterol isoprenoids including geranylg...
John D Bagert,Tom W Muir
John D Bagert
The field of epigenetics has exploded over the last two decades, revealing an astonishing level of complexity in the way genetic information is stored and accessed in eukaryotes. This expansion of knowledge, which is very much ongoing, has ...
Marcin Szczot,Alec R Nickolls,Ruby M Lam et al.
Marcin Szczot et al.
Mechanosensation is the ability to detect dynamic mechanical stimuli (e.g., pressure, stretch, and shear stress) and is essential for a wide variety of processes, including our sense of touch on the skin. How touch is detected and transduce...
The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes [0.03%]
漫谈RNA聚合酶II转录起始及相关的综合症机制研究进展
Emmanuel Compe,Jean-Marc Egly
Emmanuel Compe
In eukaryotes, transcription of protein-coding genes requires the assembly at core promoters of a large preinitiation machinery containing RNA polymerase II (RNAPII) and general transcription factors (GTFs). Transcription is potentiated by ...
Daniel R Semlow,Johannes C Walter
Daniel R Semlow
DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer predisposition syndrome, Fanconi anemia, and upregulation ...
A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters [0.03%]
天然产物化学家激活沉默型生物合成基因簇的指南
Brett C Covington,Fei Xu,Mohammad R Seyedsayamdost
Brett C Covington
Microbial natural products have provided an important source of therapeutic leads and motivated research and innovation in diverse scientific disciplines. In recent years, it has become evident that bacteria harbor a large, hidden reservoir...