Glucose-Dependent Insulinotropic Polypeptide-A Postprandial Hormone with Unharnessed Metabolic Potential [0.03%]
葡萄糖依赖性胰岛素多肽-一种具有未开发代谢潜能的餐后激素
Nunzio Guccio,Fiona M Gribble,Frank Reimann
Nunzio Guccio
Glucose-dependent insulinotropic polypeptide (GIP) is released from the upper small intestine in response to food intake and contributes to the postprandial control of nutrient disposition, including of sugars and fats. Long neglected as a ...
Han Fang,Kirsten P Stone,Desiree Wanders et al.
Han Fang et al.
The original description of dietary methionine restriction (MR) used semipurified diets to limit methionine intake to 20% of normal levels, and this reduction in dietary methionine increased longevity by ∼30% in rats. The MR diet also prod...
Reprogramming of Hepatic Metabolism and Microenvironment in Nonalcoholic Steatohepatitis [0.03%]
非酒精性 steatohepatitis 中肝脏代谢和微环境的重编程
Liangyou Rui,Jiandie D Lin
Liangyou Rui
Nonalcoholic fatty liver disease (NAFLD), a spectrum of metabolic liver disease associated with obesity, ranges from relatively benign hepatic steatosis to nonalcoholic steatohepatitis (NASH). The latter is characterized by persistent liver...
The Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease [0.03%]
神奇的脂肪酸：营养相关慢性病中的固醇类脂质
Rebekah J Nicholson,Marie K Norris,Annelise M Poss et al.
Rebekah J Nicholson et al.
Diet influences onset, progression, and severity of several chronic diseases, including heart failure, diabetes, steatohepatitis, and a subset of cancers. The prevalence and clinical burden of these obesity-linked diseases has risen over th...
The Oscillating Gut Microbiome and Its Effects on Host Circadian Biology [0.03%]
波动的肠道微生物组及其对宿主昼夜生物学的影响
Lev Litichevskiy,Christoph A Thaiss
Lev Litichevskiy
The microbial community colonizing the gastrointestinal tract, collectively termed the gut microbiota, is an important element of the host organism due to its impact on multiple aspects of health. The digestion of food, secretion of immunos...
Sohini Dutt,Iqbal Hamza,Thomas Benedict Bartnikas
Sohini Dutt
An abundant metal in the human body, iron is essential for key biological pathways including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound to heme but it can also be incorporated into iron-sulfur clusters ...
Long Noncoding RNAs That Function in Nutrition: Lnc-ing Nutritional Cues to Metabolic Pathways [0.03%]
在营养中的作用的长链非编码RNA：将营养信号与代谢途径联系起来的长链非编码RNA
Claudia D Lovell,Montserrat C Anguera
Claudia D Lovell
Long noncoding RNAs (lncRNAs) are sensitive to changing environments and play key roles in health and disease. Emerging evidence indicates that lncRNAs regulate gene expression to shape metabolic processes in response to changing nutritiona...
Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models [0.03%]
营养研究中的性作为生物学变量：从人类研究到动物模型
Yilin Chen,Minhoo Kim,Sanjana Paye et al.
Yilin Chen et al.
Biological sex is a fundamental source of phenotypic variability across species. Males and females have different nutritional needs and exhibit differences in nutrient digestion and utilization, leading to different health outcomes througho...
Shiriki K Kumanyika
Shiriki K Kumanyika
Population-based solutions are needed to stabilize and then reverse the continued upward trends in obesity prevalence in the US population and worldwide. This review focuses on the related, urgent issue of disparities in obesity prevalence ...
Katherine M Flegal
Katherine M Flegal
After a long career at the National Center for Health Statistics, I retired and joined the Stanford Prevention Research Center as an unpaid associate. I was once described by a former US Food and Drug Administration commissioner as "one of ...