Predictive Models for Health Deterioration: Understanding Disease Pathways for Personalized Medicine [0.03%]
健康恶化预测模型：理解疾病路径以实现个性化医疗
Bjoern M Eskofier,Jochen Klucken
Bjoern M Eskofier
Artificial intelligence (AI) and machine learning (ML) methods are currently widely employed in medicine and healthcare. A PubMed search returns more than 100,000 articles on these topics published between 2018 and 2022 alone. Notwithstandi...
Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function [0.03%]
直接心脏按压装置以增强心脏生物力学和功能
Jean Bonnemain,Pedro J Del Nido,Ellen T Roche
Jean Bonnemain
The treatment of end-stage heart failure has evolved substantially with advances in medical treatment, cardiac transplantation, and mechanical circulatory support (MCS) devices such as left ventricular assist devices and total artificial he...
Mechanical Control of Cell Differentiation: Insights from the Early Embryo [0.03%]
机械控制细胞分化：来自早期胚胎的启示
Celeste M Nelson
Celeste M Nelson
Differentiation is the process by which a cell activates the expression of tissue-specific genes, downregulates the expression of potency markers, and acquires the phenotypic characteristics of its mature fate. The signals that regulate dif...
Wenxuan Du,Praful Nair,Adrian Johnston et al.
Wenxuan Du et al.
Migration is an essential cellular process that regulates human organ development and homeostasis as well as disease initiation and progression. In cancer, immune and tumor cell migration is strongly associated with immune cell infiltration...
Derivation and Differentiation of Human Pluripotent Stem Cells in Microfluidic Devices [0.03%]
微流体装置中的人类多能干细胞的分离和分化
Camilla Luni,Onelia Gagliano,Nicola Elvassore
Camilla Luni
An integrative approach based on microfluidic design and stem cell biology enables capture of the spatial-temporal environmental evolution underpinning epigenetic remodeling and the morphogenetic process. We examine the body of literature t...
Improving Antibody Therapeutics by Manipulating the Fc Domain: Immunological and Structural Considerations [0.03%]
通过操控Fc区改进抗体药物：免疫学和结构方面的考虑
George Delidakis,Jin Eyun Kim,Katia George et al.
George Delidakis et al.
Interactions between the crystallizable fragment (Fc) domain of antibodies and a plethora of cellular Fc receptors (FcRs) or soluble proteins form a critical link between humoral and innate immunity. In particular, the immunoglobulin G Fc d...
Ramakrishna Mukkamala,George S Stergiou,Alberto P Avolio
Ramakrishna Mukkamala
Cuffless blood pressure (BP) measurement has become a popular field due to clinical need and technological opportunity. However, no method has been broadly accepted hitherto. The objective of this review is to accelerate progress in the dev...
Deep Learning and Medical Image Analysis for COVID-19 Diagnosis and Prediction [0.03%]
深度学习与医学图像分析在新冠肺炎诊断和预测中的应用研究
Tianming Liu,Eliot Siegel,Dinggang Shen
Tianming Liu
The coronavirus disease 2019 (COVID-19) pandemic has imposed dramatic challenges to health-care organizations worldwide. To combat the global crisis, the use of thoracic imaging has played a major role in the diagnosis, prediction, and mana...
Technologies to Assess Drug Response and Heterogeneity in Patient-Derived Cancer Organoids [0.03%]
评估患者来源的癌症类器官中药物反应和异质性的技术
Melissa C Skala,Dustin A Deming,Jeremy D Kratz
Melissa C Skala
Patient-derived cancer organoids (PDCOs) are organotypic 3D cultures grown from patient tumor samples. PDCOs provide an exciting opportunity to study drug response and heterogeneity within and between patients. This research can guide new d...
Biomaterials for Hemostasis [0.03%]
用于止血的生物材料
Aryssa Simpson,Anita Shukla,Ashley C Brown
Aryssa Simpson
Uncontrolled bleeding is a major problem in trauma and emergency medicine. While materials for trauma applications would certainly find utility in traditional surgical settings, the unique environment of emergency medicine introduces additi...