C Alberto Figueroa,Krishna Garikipati,Haizhou Yang et al.
C Alberto Figueroa et al.
Digital twins-virtual representations dynamically linked to physical systems-have the potential to transform biomedical engineering by enabling real-time prediction, optimization, and personalization in health and disease. In biofluids, dig...
Natalie M Petryk,Nghia L B Thai,Anita Shukla et al.
Natalie M Petryk et al.
As biomaterials transition from static, inert objects into dynamic scaffolds that augment the healing process, the ability to design large-scale changes in architecture in response to environmental changes is increasingly valuable. To addre...
Emilie Roncali,Amirtahà Taebi
Emilie Roncali
Cancer therapies such as chemotherapy, radiopharmaceutical therapy, and transarterial embolization rely on effective drug or radiation delivery through the bloodstream. Understanding how various drugs and particles, which form and size span...
Collagen Cross-Linking in Tendons: The Role of Lysyl Oxidase and Posttranslational Modifications in Injury, Aging, and Congenital Disorders [0.03%]
肌腱中的胶原交联：赖氨酰氧化酶和翻译后修饰在损伤、衰老和先天性疾病中的作用
Divya S Sivalingam,Ivy Vien,Catherine K Kuo
Divya S Sivalingam
Tendons enable movements by transmitting forces from muscle to bone, requiring highly specialized material properties for their mechanically demanding functions. Unfortunately, tendon material properties are frequently compromised by physic...
Embodied Sensorimotor Control: Computational Modeling of the Neural Control of Movement [0.03%]
具身感觉运动控制：运动神经控制的计算模型
Muhammad Noman Almani,John Lazzari,Jeffrey D Walker et al.
Muhammad Noman Almani et al.
We review how sensorimotor control is dictated by interacting neural populations, optimal feedback mechanisms, and the biomechanics of bodies. First, we outline the distributed anatomical loops that shuttle sensorimotor signals between cort...
Therapeutic Applications of Engineered Cell Death, Arrest, and Persistence [0.03%]
工程化细胞死亡、休眠和持久性的治疗应用
Jared W Lee-Kin,Ofelya Baghdasaryan,Luis E Contreras-Llano et al.
Jared W Lee-Kin et al.
Cells exist along a spectrum from viable to dead. Yet most cell engineering has focused primarily on the live state. This review explores how controlled manipulation of cell death or arrest can be used to build effective, safer, and more pr...
Ziquan Wei,Guorong Wu
Ziquan Wei
Light-sheet fluorescence microscopy (LSFM) has emerged as a revolutionary imaging modality for investigating intact three-dimensional brain structures at the teravoxel scale. In parallel, high-throughput computational methods, especially de...
Clinically Feasible Approaches to the Real-Time Measurement of Drugs, Metabolites, and Biomarkers in the Living Body [0.03%]
临床可行的实时测量活体药物、代谢物和生物标志物的方法
Kristine Y Ma,Heather A Clark,Kevin W Plaxco
Kristine Y Ma
The continuous, real-time measurement of specific molecules in situ in the body promises to revolutionize the precision of drug dosing, the reach of physiological research, and the accuracy and timeliness of clinical diagnostics. Motivated ...
Advancing Drug Delivery Through Complex Physiological Barriers in the Brain, Lymph Node, and Placenta [0.03%]
通过复杂生理屏障推进脑部、淋巴结和胎盘的药物输送技术的发展
Katherine M Nelson,Michael J Donzanti,Omkar S Mhatre et al.
Katherine M Nelson et al.
More than 90% of central nervous system-directed drug candidates fail because they never reach the brain, and similarly formidable physiological tissue barriers protect the placenta and lymph node. These tissues are walled off by tight junc...
Preclinical Models of Metabolic Dysfunction-Associated Steatotic Liver Disease for Therapeutic Testing [0.03%]
代谢功能障碍相关脂肪性肝病的药物研发前期模型试验研究
Alissa M Cutrone,Heidi Yeh,Korkut Uygun et al.
Alissa M Cutrone et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent hepatic pathology worldwide, with significant potential for progression to cirrhosis and ultimately end-stage liver disease. Accordingly, a wide range of...