Jeong Min Oh,Yongkuk Park,Jungwoo Lee et al.
Jeong Min Oh et al.
Despite the advances in detection, diagnosis, and treatments, cancer remains a lethal disease, claiming the lives of more than 600,000 people in the United States alone in 2024. To accelerate the development of new therapeutic strategies wi...
Francesco Andreatta,Delilah Hendriks,Benedetta Artegiani
Francesco Andreatta
Over the last decade, a plethora of organoid models have been generated to recapitulate aspects of human development, disease, tissue homeostasis, and repair. Organoids representing multiple tissues have emerged and are typically categorize...
Dennis Hein,Afshin Bozorgpour,Dorit Merhof et al.
Dennis Hein et al.
Physics-inspired generative models (GMs), in particular diffusion models and Poisson flow models, enhance Bayesian methods and promise great utility in medical imaging. This review examines the transformative role of such generative methods...
Dietmar M Wohlbauer,Norbert Dillier
Dietmar M Wohlbauer
Cochlear implants are the most successful neural prostheses used to restore hearing in severe-to-profound hearing-impaired individuals. The field of cochlear implant coding investigates interdisciplinary approaches to translate acoustic sig...
Conformable Piezoelectric Devices and Systems for Advanced Wearable and Implantable Biomedical Applications [0.03%]
用于先进可穿戴和植入式生物医学应用的顺应性压电器件及系统
Jin-Hoon Kim,Hyeokjun Yoon,Shrihari Viswanath et al.
Jin-Hoon Kim et al.
With increasing demands for continuous health monitoring remotely, wearable and implantable devices have attracted considerable interest. To fulfill such demands, novel materials and device structures have been investigated, since commercia...
Yu Jung Shin,Dina Safina,Ying Zheng et al.
Yu Jung Shin et al.
The microvasculature, a complex network of small blood vessels, connects systemic circulation with local tissues, facilitating the nutrient and oxygen exchange that is critical for homeostasis and organ function. Engineering these structure...
Leveraging Preclinical Modeling for Clinical Advancements in Single Ventricle Physiology: Spotlight on the Fontan Circulation [0.03%]
利用前临床模型推动单心室生理学的临床进展：重点关注Fontan循环
Andreas Escher,Carlos Aguilar Vega,Markus A Horvath et al.
Andreas Escher et al.
Preclinical modeling of human circulation has been instrumental in advancing cardiovascular medicine. Alongside clinical research, the armamentarium of computational (e.g., lumped parameter or computational fluid dynamics) and experimental ...
The Evolution of Systems Biology and Systems Medicine: From Mechanistic Models to Uncertainty Quantification [0.03%]
系统生物学与系统医学的演变：从机制模型到不确定性量化
Lingxia Qiao,Ali Khalilimeybodi,Nathaniel J Linden-Santangeli et al.
Lingxia Qiao et al.
Understanding interaction mechanisms within cells, tissues, and organisms is crucial for driving developments across biology and medicine. Mathematical modeling is an essential tool for simulating such biological systems. Building on experi...
Therapeutic Ultrasound for Multimodal Cancer Treatment: A Spotlight on Breast Cancer [0.03%]
治疗超声在多模式癌症治疗中的应用：聚焦于乳腺癌
Zehra E F Demir,Natasha D Sheybani
Zehra E F Demir
Cancer remains a leading cause of mortality worldwide, and the demand for improved efficacy, precision, and safety of management options has never been greater. Focused ultrasound (FUS) is a rapidly emerging strategy for nonionizing, noninv...
Replicating Host-Microbiome Interactions: Harnessing Organ-on-a-Chip and Organoid Technologies to Model Vaginal and Lung Physiology [0.03%]
宿主-微生物群相互作用的模拟：利用器官芯片和类器官技术来模拟阴道和肺生理功能
Jade Coxon,Emily Linder,Caden Sweet et al.
Jade Coxon et al.
Organ-on-a-chip (OOC) and organoid technologies are at the forefront of developing sophisticated in vitro systems that replicate complex host-microbiome interactions, including those associated with vaginal health and lung infection. We exp...