Regulation of Tumor Invasion by the Physical Microenvironment: Lessons from Breast and Brain Cancer [0.03%]
肿瘤侵袭的物理微环境调控：来自乳腺癌和脑瘤的启示
Garrett F Beeghly,Kwasi Y Amofa,Claudia Fischbach et al.
Garrett F Beeghly et al.
The success of anticancer therapies is often limited by heterogeneity within and between tumors. While much attention has been devoted to understanding the intrinsic molecular diversity of tumor cells, the surrounding tissue microenvironmen...
Detection and Monitoring of Viral Infections via Wearable Devices and Biometric Data [0.03%]
通过可穿戴设备和生物识别数据检测和监测病毒感染
Craig J Goergen,MacKenzie J Tweardy,Steven R Steinhubl et al.
Craig J Goergen et al.
Mounting clinical evidence suggests that viral infections can lead to detectable changes in an individual's normal physiologic and behavioral metrics, including heart and respiration rates, heart rate variability, temperature, activity, and...
Luis Fernando Velásquez-García,Yosef Kornbluth
Luis Fernando Velásquez-García
Additive manufacturing's attributes include print customization, low per-unit cost for small- to mid-batch production, seamless interfacing with mainstream medical 3D imaging techniques, and feasibility to create free-form objects in materi...
Jay D Humphrey,Martin A Schwartz
Jay D Humphrey
Cells of the vascular wall are exquisitely sensitive to changes in their mechanical environment. In healthy vessels, mechanical forces regulate signaling and gene expression to direct the remodeling needed for the vessel wall to maintain op...
Cynthia Hajal,Baptiste Le Roi,Roger D Kamm et al.
Cynthia Hajal et al.
The blood-brain barrier (BBB) is one of the most selective endothelial barriers. An understanding of its cellular, morphological, and biological properties in health and disease is necessary to develop therapeutics that can be transported f...
Deanna Broadwater,Hyllana C D Medeiros,Richard R Lunt et al.
Deanna Broadwater et al.
Photoactive agents are promising complements for both early diagnosis and targeted treatment of cancer. The dual combination of diagnostics and therapeutics is known as theranostics. Photoactive theranostic agents are activated by a specifi...
Lydia Bourouiba
Lydia Bourouiba
The host-to-host transmission of respiratory infectious diseases is fundamentally enabled by the interaction of pathogens with a variety of fluids (gas or liquid) that shape pathogen encapsulation and emission, transport and persistence in ...
Yaron Bram,Duc-Huy T Nguyen,Vikas Gupta et al.
Yaron Bram et al.
Liver disease is an important clinical problem, impacting 600 million people worldwide. It is the 11th-leading cause of death in the world. Despite constant improvement in treatment and diagnostics, the aging population and accumulated risk...
Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science [0.03%]
结合生物材料和基因组编辑方法推动生物医学科学的发展
Amr A Abdeen,Brian D Cosgrove,Charles A Gersbach et al.
Amr A Abdeen et al.
The recent discovery and subsequent development of the CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat-CRISPR-associated protein 9) platform as a precise genome editing tool have transformed biomedicine. As these CRISP...
Jennifer H Hammel,Sophie R Cook,Maura C Belanger et al.
Jennifer H Hammel et al.
Modeling immunity in vitro has the potential to be a powerful tool for investigating fundamental biological questions, informing therapeutics and vaccines, and providing new insight into disease progression. There are two major elements to ...