Chen Xie,Tingting Zhang,Zhenpeng Qin
Chen Xie
Selective and remote manipulation of activity for biomolecules, including protein, DNA, and lipids, is crucial to elucidate their molecular function and to develop biomedical applications. While advances in tool development, such as optogen...
Direct Electron Transfer-Type Oxidoreductases for Biomedical Applications [0.03%]
用于生物医学应用的直接电子转移型氧化还原酶
Keisei Sowa,Junko Okuda-Shimazaki,Eole Fukawa et al.
Keisei Sowa et al.
Among the various types of enzyme-based biosensors, sensors utilizing enzymes capable of direct electron transfer (DET) are recognized as the most ideal. However, only a limited number of redox enzymes are capable of DET with electrodes, th...
Recent Developments in Aerosol Pulmonary Drug Delivery: New Technologies, New Cargos, and New Targets [0.03%]
气溶胶肺部药物递送方面的最新发展：新技术、新载荷和新靶点
Ian R Woodward,Catherine A Fromen
Ian R Woodward
There is nothing like a global pandemic to motivate the need for improved respiratory treatments and mucosal vaccines. Stimulated by the COVID-19 pandemic, pulmonary aerosol drug delivery has seen a flourish of activity, building on the pri...
Samira Musah,Rohan Bhattacharya,Jonathan Himmelfarb
Samira Musah
Kidney disease is a global health crisis affecting more than 850 million people worldwide. In the United States, annual Medicare expenditures for kidney disease and organ failure exceed $81 billion. Efforts to develop targeted therapeutics ...
CRISPR/Cas Technology: The Unique Synthetic Biology Genome-Editing Tool Shifting the Paradigm in Viral Diagnostics, Defense, and Therapeutics [0.03%]
CRISPR/Cas技术：独特的合成生物学基因编辑工具正在改变病毒诊断、防御和治疗的范式
Lang Zhou,Aleksandr L Simonian
Lang Zhou
The emergence of the COVID-19 pandemic has starkly exposed our significantly limited ability to promptly identify and respond to emergent biological threats. Consequently, there is an urgent need to advance biotechnological methods for addr...
Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound [0.03%]
组织拆解术：一种用超声波进行机械性组织消融的方法
Zhen Xu,Tatiana D Khokhlova,Clifford S Cho et al.
Zhen Xu et al.
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to conventional high-intensity focused ultrasound thermal t...
Insertable Biosensors: Combining Implanted Sensing Materials with Wearable Monitors [0.03%]
可植入生物传感器：将植入感应材料与可穿戴设备结合在一起
David Chimene,Kirstie M K Queener,Brian S Ko et al.
David Chimene et al.
Insertable biosensor systems are medical diagnostic devices with two primary components: an implantable biosensor within the body and a wearable monitor that can remotely interrogate the biosensor from outside the body. Because the biosenso...
Conor Loy,Lauren Ahmann,Iwijn De Vlaminck et al.
Conor Loy et al.
This review delves into the rapidly evolving landscape of liquid biopsy technologies based on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in precision medicine. With the advent of high-throughput DN...
3D Traction Force Microscopy in Biological Gels: From Single Cells to Multicellular Spheroids [0.03%]
生物凝胶中的三维牵引力显微镜技术：从单细胞到多细胞类球体
Brian C H Cheung,Rana J Abbed,Mingming Wu et al.
Brian C H Cheung et al.
Cell traction force plays a critical role in directing cellular functions, such as proliferation, migration, and differentiation. Current understanding of cell traction force is largely derived from 2D measurements where cells are plated on...
Advancing Point-of-Care Applications with Droplet Microfluidics: From Single-Cell to Multicellular Analysis [0.03%]
微滴微流控推进现场应用：从单细胞到多细胞分析
Christina Sharkey,Rachel White,Michael Finocchiaro et al.
Christina Sharkey et al.
Recent advances in single-cell and multicellular microfluidics technology have provided powerful tools for studying cancer biology and immunology. The ability to create controlled microenvironments, perform high-throughput screenings, and m...