Systems biology through mouse imaging centers: experience and new directions [0.03%]
系统生物成像分析中心的模式与经验：小鼠模型及新方向
R Mark Henkelman
R Mark Henkelman
The completed sequencing of genomes has forced upon us the challenge of understanding how the detailed information in the genome gives rise to the specific characteristics--phenotype--of the individual. This is crucial for understanding not...
Biomechanics of pressure ulcer in body tissues interacting with external forces during locomotion [0.03%]
人体组织在运动中与外力交互作用的压伤生物力学
Arthur F T Mak,Ming Zhang,Eric W C Tam
Arthur F T Mak
Forces acting on the body via various external surfaces during locomotion are needed to support the body under gravity, control posture, and overcome inertia. Examples include the forces acting on the body via the seating surfaces during wh...
Bradley J Nelson,Ioannis K Kaliakatsos,Jake J Abbott
Bradley J Nelson
Microrobots have the potential to revolutionize many aspects of medicine. These untethered, wirelessly controlled and powered devices will make existing therapeutic and diagnostic procedures less invasive and will enable new procedures neve...
Biju Parekkadan,Jack M Milwid
Biju Parekkadan
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a new therapeutic for treating a variety of immune-mediated diseases. First heralded as a regenerative therapy for skeletal tissue repair, MSCs have r...
microRNA: a master regulator of cellular processes for bioengineering systems [0.03%]
微RNA：生物工程系统的细胞过程总调控开关
Wei Sun,Yi-Shuan Julie Li,Hsien-Da Huang et al.
Wei Sun et al.
microRNAs (miRNAs) are small RNAs 18 to 24 nucleotides in length that serve the pivotal function of regulating gene expression. Instead of being translated into proteins, the mature single-stranded miRNA binds to messenger RNAs (mRNAs) to i...
James A Ashton-Miller,John O L Delancey
James A Ashton-Miller
Approximately 11% of U.S. women undergo surgery for pelvic floor dysfunction, including genital organ prolapse and urinary and fecal incontinence. The major risk factor for developing these conditions is giving vaginal birth. Vaginal birth ...
Konstantinos Konstantopoulos,Susan N Thomas
Konstantinos Konstantopoulos
Metastasis is a highly regulated, multistep process in which cancerous cells shed from the primary tumor and enter the circulatory system, where they interact extensively with host cells before they lodge and colonize the target organ. The ...
Michael S Sacks,Frederick J Schoen,John E Mayer
Michael S Sacks
Surgical replacement of diseased heart valves by mechanical and tissue valve substitutes is now commonplace and enhances survival and quality of life for many patients. However, repairs of congenital deformities require very small valve siz...
Living-cell microarrays [0.03%]
活细胞微阵列技术
Martin L Yarmush,Kevin R King
Martin L Yarmush
Living cells are remarkably complex. To unravel this complexity, living-cell assays have been developed that allow delivery of experimental stimuli and measurement of the resulting cellular responses. High-throughput adaptations of these as...
Gang Bao,Won Jong Rhee,Andrew Tsourkas
Gang Bao
Commonly used techniques for analyzing gene expression, such as polymerase chain reaction (PCR), microarrays, and in situ hybridization, have proven invaluable in understanding RNA processing and regulation. However, these techniques rely o...