Christopher R Jacobs,Sara Temiyasathit,Alesha B Castillo
Christopher R Jacobs
An impressive range of tissues and cells are regulated by mechanical loading, and this regulation is central to disease processes such as osteoporosis, atherosclerosis, and osteoarthritis. However, other than a small number of specialized e...
Nada N Boustany,Stephen A Boppart,Vadim Backman
Nada N Boustany
Optical contrast based on elastic scattering interactions between light and matter can be used to probe cellular structure, cellular dynamics, and image tissue architecture. The quantitative nature and high sensitivity of light scattering s...
Jens Rittscher
Jens Rittscher
The systems-level analysis of complex biological processes requires methods that enable the quantification of a broad range of phenotypical alterations, the precise localization of signaling events, and the ability to correlate such signali...
Sickle cell biomechanics [0.03%]
镰状细胞生物力学
Gilda A Barabino,Manu O Platt,Dhananjay K Kaul
Gilda A Barabino
As the predominant cell type in blood, red blood cells (RBCs) and their biomechanical properties largely determine the rheological and hemodynamic behavior of blood in normal and disease states. In sickle cell disease (SCD), mechanically fr...
Mechanisms of defibrillation [0.03%]
除颤机制
Derek J Dosdall,Vladimir G Fast,Raymond E Ideker
Derek J Dosdall
Electrical shock has been the one effective treatment for ventricular fibrillation for several decades. With the advancement of electrical and optical mapping techniques, histology, and computer modeling, the mechanisms responsible for defi...
Daniel Irimia
Daniel Irimia
Most cells in the body have the ability to change their physical locations during physiologic or pathologic events such as inflammation, wound healing, or cancer. When cell migration is directed toward sources of cue chemicals, the process ...
Diane Hoffman-Kim,Jennifer A Mitchel,Ravi V Bellamkonda
Diane Hoffman-Kim
In the body, cells encounter a complex milieu of signals, including topographical cues, in the form of the physical features of their surrounding environment. Imposed topography can affect cells on surfaces by promoting adhesion, spreading,...
Richard N Zare,Samuel Kim
Richard N Zare
Microfluidics, the study and control of the fluidic behavior in microstructures, has emerged as an important enabling tool for single-cell chemical analysis. The complex procedures for chemical cytometry experiments can be integrated into a...
Scott Banta,Ian R Wheeldon,Mark Blenner
Scott Banta
Proteins, which are natural heteropolymers, have evolved to exhibit a staggering array of functions and capabilities. As scientists and engineers strive to tackle important challenges in medicine, novel biomaterials continue to be devised, ...
Kevin Cleary,Terry M Peters
Kevin Cleary
Image-guided interventions are medical procedures that use computer-based systems to provide virtual image overlays to help the physician precisely visualize and target the surgical site. This field has been greatly expanded by the advances...