Nuclear mechanics in disease [0.03%]
疾病中的核机械学
Monika Zwerger,Chin Yee Ho,Jan Lammerding
Monika Zwerger
Over the past two decades, the biomechanical properties of cells have emerged as key players in a broad range of cellular functions, including migration, proliferation, and differentiation. Although much of the attention has focused on the ...
Technologies for micromanipulating, imaging, and phenotyping small invertebrates and vertebrates [0.03%]
操控、成像和表型化小型无脊椎动物和小型脊椎动物的技术
Mehmet Fatih Yanik,Christopher B Rohde,Carlos Pardo-Martin
Mehmet Fatih Yanik
Small multicellular model organisms such as the invertebrate nematode C. elegans and the vertebrate zebrafish provide unique opportunities for both basic science and pharmaceutical discovery. In recent years, there have been significant bre...
Leaf Huang,Yang Liu
Leaf Huang
RNA interference (RNAi) technology represents a fundamentally new category of treatments for human disease by addressing targets that are traditionally considered undruggable with existing medicines. The major challenge for RNAi-based thera...
Henry Hess
Henry Hess
Biomolecular motors, in particular motor proteins from the kinesin and myosin families, can be used to explore engineering applications of molecular motors in general. Their outstanding performance enables the experimental study of hybrid s...
Song Li,Jeffrey J D Henry
Song Li
Cardiovascular devices such as vascular grafts, stents, and heart valves have been widely used to treat cardiovascular diseases. The failure of these devices is usually initiated by the formation of thrombus and neointima on the device surf...
Philip R LeDuc,William C Messner,John P Wikswo
Philip R LeDuc
Control is intrinsic to biological organisms, whose cells are in a constant state of sensing and response to numerous external and self-generated stimuli. Diverse means are used to study the complexity through control-based approaches in th...
Mapping fetal brain development in utero using magnetic resonance imaging: the Big Bang of brain mapping [0.03%]
应用磁共振成像技术绘制胎儿期大脑发育过程：大脑绘图的“大爆炸”阶段
Colin Studholme
Colin Studholme
The development of tools to construct and investigate probabilistic maps of the adult human brain from magnetic resonance imaging (MRI) has led to advances in both basic neuroscience and clinical diagnosis. These tools are increasingly bein...
Gordana Vunjak-Novakovic,Kathy O Lui,Nina Tandon et al.
Gordana Vunjak-Novakovic et al.
The idea of extending the lifetime of our organs is as old as humankind, fueled by major advances in organ transplantation, novel drugs, and medical devices. However, true regeneration of human tissue has become increasingly plausible only ...
Jeffrey W Ruberti,Abhijit Sinha Roy,Cynthia J Roberts
Jeffrey W Ruberti
The ability to clearly observe one's environment in the visible spectrum provides a tremendous evolutionary advantage in most of the world's habitats. The complex optical processing system that has evolved in higher vertebrate animals gathe...
Daniel J Mirota,Masaru Ishii,Gregory D Hager
Daniel J Mirota
The trend toward minimally invasive surgical interventions has created new challenges for visualization during surgical procedures. However, at the same time, the introduction of high-definition digital endoscopy offers the opportunity to a...