Regulation of cell behavior and tissue patterning by bioelectrical signals: challenges and opportunities for biomedical engineering [0.03%]
生物电信号调控细胞行为和组织模式化：生物医学工程面临的挑战与机遇
Michael Levin,Claire G Stevenson
Michael Levin
Achieving control over cell behavior and pattern formation requires molecular-level understanding of regulatory mechanisms. Alongside transcriptional networks and biochemical gradients, there functions an important system of cellular commun...
Continuum mixture models of biological growth and remodeling: past successes and future opportunities [0.03%]
连续混合模型在生物生长和重塑中的过去成功与未来机遇
G A Ateshian,J D Humphrey
G A Ateshian
Biological growth processes involve mass exchanges that increase, decrease, or replace material that constitutes cells, tissues, and organs. In most cases, such exchanges alter the structural makeup of the material and consequently affect a...
Pramod B Voleti,Mark R Buckley,Louis J Soslowsky
Pramod B Voleti
Injury and degeneration of tendon, the soft tissue that mechanically links muscle and bone, can cause substantial pain and loss of function. This review discusses the composition and function of healthy tendon and describes the structural, ...
Quantitative imaging methods for the development and validation of brain biomechanics models [0.03%]
脑力学模型发展与验证的定量影像方法研究
Philip V Bayly,Erik H Clayton,Guy M Genin
Philip V Bayly
Rapid deformation of brain tissue in response to head impact or acceleration can lead to numerous pathological changes, both immediate and delayed. Modeling and simulation hold promise for illuminating the mechanisms of traumatic brain inju...
Rui P Martins,John D Finan,Farshid Guilak et al.
Rui P Martins et al.
Mechanical loading induces both nuclear distortion and alterations in gene expression in a variety of cell types. Mechanotransduction is the process by which extracellular mechanical forces can activate a number of well-studied cytoplasmic ...
Pietro Valdastri,Massimiliano Simi,Robert J Webster rd
Pietro Valdastri
The gastrointestinal tract is home to some of the most deadly human diseases. Exacerbating the problem is the difficulty of accessing it for diagnosis or intervention and the concomitant patient discomfort. Flexible endoscopy has establishe...
Irene Georgakoudi,Kyle P Quinn
Irene Georgakoudi
Optical microscopic imaging offers opportunities to perform noninvasive assessments of numerous parameters associated with the biochemistry, morphology, and functional state of biological samples. For example, it is possible to detect the e...
Brian Scassellati,Henny Admoni,Maja Matarić
Brian Scassellati
Autism spectrum disorders are a group of lifelong disabilities that affect people's ability to communicate and to understand social cues. Research into applying robots as therapy tools has shown that robots seem to improve engagement and el...
Allen A Cheng,Timothy K Lu
Allen A Cheng
Over the past decade, synthetic biology has emerged as an engineering discipline for biological systems. Compared with other substrates, biology poses a unique set of engineering challenges resulting from an incomplete understanding of natu...
Travis J Gould,Samuel T Hess,Joerg Bewersdorf
Travis J Gould
Recent advances in far-field microscopy have demonstrated that fluorescence imaging is possible at resolutions well below the long-standing diffraction limit. By exploiting photophysical properties of fluorescent probe molecules, this new c...