Engineered culture models for studies of tumor-microenvironment interactions [0.03%]
用于研究肿瘤-微环境相互作用的工程化模型细胞文化模型
David W Infanger,Maureen E Lynch,Claudia Fischbach
David W Infanger
Heterogeneous microenvironmental conditions play critical roles in cancer pathogenesis and therapy resistance and arise from changes in tissue dimensionality, cell-extracellular matrix (ECM) interactions, soluble factor signaling, oxygen as...
Scott Banta,Kevin Dooley,Oren Shur
Scott Banta
Nature's reliance on proteins to carry out nearly all biological processes has led to the evolution of biomolecules that exhibit a seemingly endless range of functions. Much research has been devoted toward advancing this process in the lab...
Joseph Walpole,Jason A Papin,Shayn M Peirce
Joseph Walpole
Integration of data across spatial, temporal, and functional scales is a primary focus of biomedical engineering efforts. The advent of powerful computing platforms, coupled with quantitative data from high-throughput experimental methodolo...
Atlas-based neuroinformatics via MRI: harnessing information from past clinical cases and quantitative image analysis for patient care [0.03%]
基于MRI的 atlas 发动的神经信息学：利用过去的临床病例及定量图像分析为患者服务
Susumu Mori,Kenichi Oishi,Andreia V Faria et al.
Susumu Mori et al.
With the ever-increasing amount of anatomical information radiologists have to evaluate for routine diagnoses, computational support that facilitates more efficient education and clinical decision making is highly desired. Despite the rapid...
François A Auger,Laure Gibot,Dan Lacroix
François A Auger
Vascularization is one of the great challenges that tissue engineering faces in order to achieve sizeable tissue and organ substitutes that contain living cells. There are instances, such as skin replacement, in which a tissue-engineered su...
Functional attachment of soft tissues to bone: development, healing, and tissue engineering [0.03%]
软组织与骨的连接：发育、修复和组织工程学问题
Helen H Lu,Stavros Thomopoulos
Helen H Lu
Connective tissues such as tendons or ligaments attach to bone across a multitissue interface with spatial gradients in composition, structure, and mechanical properties. These gradients minimize stress concentrations and mediate load trans...
Gang Bao,Samir Mitragotri,Sheng Tong
Gang Bao
Recent advances in nanotechnology and growing needs in biomedical applications have driven the development of multifunctional nanoparticles. These nanoparticles, through nanocrystalline synthesis, advanced polymer processing, and coating an...
Kristian Franze,Paul A Janmey,Jochen Guck
Kristian Franze
Biological cells are well known to respond to a multitude of chemical signals. In the nervous system, chemical signaling has been shown to be crucially involved in development, normal functioning, and disorders of neurons and glial cells. H...
Thomas V Colace,Garth W Tormoen,Owen J T McCarty et al.
Thomas V Colace et al.
The study of blood ex vivo can occur in closed or open systems, with or without flow. Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate analysis of platelet function, coagulation biology, ce...
Mónica Beato Coelho,Joaquim M S Cabral,Jeffrey M Karp
Mónica Beato Coelho
Stem cells hold significant promise for regeneration of tissue defects and disease-modifying therapies. Although numerous promising stem cell approaches are advancing in clinical trials, intraoperative stem cell therapies offer more immedia...