Electroporation-based technologies for medicine: principles, applications, and challenges [0.03%]
电穿孔的医学应用：原理、应用与挑战
Martin L Yarmush,Alexander Golberg,Gregor Serša et al.
Martin L Yarmush et al.
When high-amplitude, short-duration pulsed electric fields are applied to cells and tissues, the permeability of the cell membranes and tissue is increased. This increase in permeability is currently explained by the temporary appearance of...
3D biofabrication strategies for tissue engineering and regenerative medicine [0.03%]
组织工程与再生医学的三维生物制造策略
Piyush Bajaj,Ryan M Schweller,Ali Khademhosseini et al.
Piyush Bajaj et al.
Over the past several decades, there has been an ever-increasing demand for organ transplants. However, there is a severe shortage of donor organs, and as a result of the increasing demand, the gap between supply and demand continues to wid...
From unseen to seen: tackling the global burden of uncorrected refractive errors [0.03%]
从未被发现到被重视：应对未矫正屈光不正的全球疾病负担
Nicholas J Durr,Shivang R Dave,Eduardo Lage et al.
Nicholas J Durr et al.
Worldwide, more than one billion people suffer from poor vision because they do not have the eyeglasses they need. Their uncorrected refractive errors are a major cause of global disability and drastically reduce productivity, educational o...
John-Michael Williford,Juan Wu,Yong Ren et al.
John-Michael Williford et al.
Inhibiting specific gene expression by short interfering RNA (siRNA) offers a new therapeutic strategy to tackle many diseases, including cancer, metabolic disorders, and viral infections, at the molecular level. The macromolecular and pola...
John M Tarbell,Scott I Simon,Fitz-Roy E Curry
John M Tarbell
Mammals are endowed with a complex set of mechanisms that sense mechanical forces imparted by blood flow to endothelial cells (ECs), smooth muscle cells, and circulating blood cells to elicit biochemical responses through a process referred...
G J Verkerke,S L Thomson
G J Verkerke
Advanced laryngeal cancer sometimes necessitates the removal of the complete larynx. This procedure involves suturing the trachea to an opening in the neck, the most disturbing consequence of which is the loss of voice. Since 1859, several ...
Lonnie D Shea,Teresa K Woodruff,Ariella Shikanov
Lonnie D Shea
Chemo- and radiation therapies used to treat cancer can have the unintended effect of making patients infertile. Clinically established fertility preservation methods, such as egg and embryo cryopreservation, are not applicable to all patie...
Blood substitutes [0.03%]
血液替代品
Andre F Palmer,Marcos Intaglietta
Andre F Palmer
The toxic side effects of early generations of red blood cell substitutes have stimulated development of more safe and efficacious high-molecular-weight polymerized hemoglobins, poly(ethylene glycol)-conjugated hemoglobins, and vesicle-enca...
Wei Sun,Caitlin Martin,Thuy Pham
Wei Sun
In the past two decades, major advances have been made in the clinical evaluation and treatment of valvular heart disease owing to the advent of noninvasive cardiac imaging modalities. In clinical practice, valvular disease evaluation is ty...
Kareen L K Coulombe,Vivek K Bajpai,Stelios T Andreadis et al.
Kareen L K Coulombe et al.
Heart disease is the leading cause of morbidity and mortality worldwide, and regenerative therapies that replace damaged myocardium could benefit millions of patients annually. The many cell types in the heart, including cardiomyocytes, end...