David J Mogul,Wim van Drongelen
David J Mogul
Epilepsy afflicts approximately 1-2% of the world's population. The mainstay therapy for treating the chronic recurrent seizures that are emblematic of epilepsy are drugs that manipulate levels of neuronal excitability in the brain. However...
B Shapiro,S Kulkarni,A Nacev et al.
B Shapiro et al.
Magnetic fields have the potential to noninvasively direct and focus therapy to disease targets. External magnets can apply forces on drug-coated magnetic nanoparticles, or on living cells that contain particles, and can be used to manipula...
Daniel Thomas Ginat,Rajiv Gupta
Daniel Thomas Ginat
Computed tomography (CT) is an essential tool in diagnostic imaging for evaluating many clinical conditions. In recent years, there have been several notable advances in CT technology that already have had or are expected to have a signific...
Deanna M Thompson,Abigail N Koppes,John G Hardy et al.
Deanna M Thompson et al.
Electrical stimulation to manipulate the central nervous system (CNS) has been applied as early as the 1750s to produce visual sensations of light. Deep brain stimulation (DBS), cochlear implants, visual prosthetics, and functional electric...
Rakesh K Jain,John D Martin,Triantafyllos Stylianopoulos
Rakesh K Jain
Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase c...
Melissa R Warden,Jessica A Cardin,Karl Deisseroth
Melissa R Warden
Genetically encoded optical actuators and indicators have changed the landscape of neuroscience, enabling targetable control and readout of specific components of intact neural circuits in behaving animals. Here, we review the development o...
Joseph M Martel,Mehmet Toner
Joseph M Martel
When Segré and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating at an annulus in the pipe, scientists were perplexed and spent decades learning why such behavior occurred, finally understanding that it was caused ...
Karen K Hirschi,Song Li,Krishnendu Roy
Karen K Hirschi
With the discovery of induced pluripotent stem (iPS) cells, it is now possible to convert differentiated somatic cells into multipotent stem cells that have the capacity to generate all cell types of adult tissues. Thus, there is a wide var...
Effects of biomechanical properties of the bone-implant interface on dental implant stability: from in silico approaches to the patient's mouth [0.03%]
种植体骨界面的生物力学性能对牙种植稳定性的影响：从计算机模拟到患者口腔中的研究
Guillaume Haïat,Hom-Lay Wang,John Brunski
Guillaume Haïat
Dental implants have become a routinely used technique in dentistry for replacing teeth. However, risks of failure are still experienced and remain difficult to anticipate. Multiscale phenomena occurring around the implant interface determi...
Lihong V Wang,Liang Gao
Lihong V Wang
Photoacoustic imaging (PAI) of biological tissue has seen immense growth in the past decade, providing unprecedented spatial resolution and functional information at depths in the optical diffusive regime. PAI uniquely combines the advantag...