Melissa A Kotterman,Thomas W Chalberg,David V Schaffer
Melissa A Kotterman
In a range of human trials, viral vectors have emerged as safe and effective delivery vehicles for clinical gene therapy, particularly for monogenic recessive disorders, but there has also been early work on some idiopathic diseases. These ...
Chi Zhang,Delong Zhang,Ji-Xin Cheng
Chi Zhang
Advancements in coherent Raman scattering (CRS) microscopy have enabled label-free visualization and analysis of functional, endogenous biomolecules in living systems. When compared with spontaneous Raman microscopy, a key advantage of CRS ...
Nathan A Hotaling,Li Tang,Darrell J Irvine et al.
Nathan A Hotaling et al.
Strategies to enhance, suppress, or qualitatively shape the immune response are of importance for diverse biomedical applications, such as the development of new vaccines, treatments for autoimmune diseases and allergies, strategies for reg...
Andrew S LaCroix,Katheryn E Rothenberg,Brenton D Hoffman
Andrew S LaCroix
Mechanical stimuli are known to be potent regulators of the form and function of cells and organisms. Although biological regulation has classically been understood in terms of principles from solution biochemistry, advancements in many fie...
Francis Cui,Minsoung Rhee,Anup Singh et al.
Francis Cui et al.
Fast and reliable diagnoses are invaluable in clinical care. Samples (e.g., blood, urine, and saliva) are collected and analyzed for various biomarkers to quickly and sensitively assess disease progression, monitor response to treatment, an...
Julio Saez-Rodriguez,Aidan MacNamara,Simon Cook
Julio Saez-Rodriguez
Cell signaling pathways control cells' responses to their environment through an intricate network of proteins and small molecules partitioned by intracellular structures, such as the cytoskeleton and nucleus. Our understanding of these pat...
Advances in Antibody Design [0.03%]
抗体设计的新进展
Kathryn E Tiller,Peter M Tessier
Kathryn E Tiller
The use of monoclonal antibodies as therapeutics requires optimizing several of their key attributes. These include binding affinity and specificity, folding stability, solubility, pharmacokinetics, effector functions, and compatibility wit...
Qing Zhou,Kyungjin Son,Ying Liu et al.
Qing Zhou et al.
Biosensors first appeared several decades ago to address the need for monitoring physiological parameters such as oxygen or glucose in biological fluids such as blood. More recently, a new wave of biosensors has emerged in order to provide ...
Eric M Darling,Dino Di Carlo
Eric M Darling
Traditionally, cell analysis has focused on using molecular biomarkers for basic research, cell preparation, and clinical diagnostics; however, new microtechnologies are enabling evaluation of the mechanical properties of cells at throughpu...
Majid Ebrahimi Warkiani,Lidan Wu,Andy Kah Ping Tay et al.
Majid Ebrahimi Warkiani et al.
Microfluidic cell-separation technologies have been studied for almost two decades, but the limited throughput has restricted their impact and range of application. Recent advances in microfluidics enable high-throughput cell sorting and se...