A Theoretical Approach in Applying High-Frequency Acoustic and Elasticity Microscopy to Assess Cells and Tissues [0.03%]
运用高频声学和弹性显微镜评估细胞和组织的理论方法
Frank Winterroth,Jing Wang,Onno Wink et al.
Frank Winterroth et al.
Medical ultrasound is a diagnostic imaging modality used for visualizing internal organs; the frequencies typically used are 2-10 MHz. Scanning acoustic microscopy (SAM) is a form of ultrasound where frequencies typically exceed 50 MHz. Inc...
Lessons Learned and Challenges Ahead in the Translation of Implantable Microscale Sensors and Actuators [0.03%]
植入式微尺度传感器和执行器的研制心得与面临的挑战
Jae Young Park,Nikolas Barrera,Tianyu Bai et al.
Jae Young Park et al.
Microscale sensors and actuators have been widely explored by the scientific community to augment the functionality of conventional medical implants. However, despite the many innovative concepts proposed, a negligible fraction has successf...
Supracortical Microstimulation: Advances in Microelectrode Design and In Vivo Validation [0.03%]
超皮质微刺激：微型电极设计的进展及在体验证
Cecilia Schmitz,J Evan Smith,Iakov Rachinskiy et al.
Cecilia Schmitz et al.
Electrical stimulation of the brain is being developed as a treatment for an increasing number of neurological disorders. Technologies for delivering electrical stimulation are advancing rapidly and vary in specificity, coverage, and invasi...
Emerging Technologies for Multiphoton Writing and Reading of Polymeric Architectures for Biomedical Applications [0.03%]
用于生物医学应用的聚合物结构的多光子写入和读取的新兴技术
Jieliyue Sun,Sixian Jia,Chenhui Shao et al.
Jieliyue Sun et al.
The rise in popularity of two-photon polymerization (TPP) as an additive manufacturing technique has impacted many areas of science and engineering, particularly those related to biomedical applications. Compared with other fabrication meth...
Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion [0.03%]
设计器官：机器灌注时代的伦理基因改良
Irina Filz von Reiterdank,Raphaela Bento,Insoo Hyun et al.
Irina Filz von Reiterdank et al.
Gene therapy is a rapidly developing field, finally yielding clinical benefits. Genetic engineering of organs for transplantation may soon be an option, thanks to convergence with another breakthrough technology, ex vivo machine perfusion (...
Tuba Marjan,Nuria Lafuente-Gómez,Akaansha Rampal et al.
Tuba Marjan et al.
Biochemical signals in native tissue microenvironments instruct cell behavior during many biological processes ranging from developmental morphogenesis and tissue regeneration to tumor metastasis and disease progression. The detection and c...
William J Polacheck,J Brandon Dixon,Wen Yih Aw
William J Polacheck
The lymphatic vasculature plays critical roles in maintaining fluid homeostasis, transporting lipid, and facilitating immune surveillance. A growing body of work has identified lymphatic dysfunction as contributing to the severity of myriad...
Neurons as Immunomodulators: From Rapid Neural Activity to Prolonged Regulation of Cytokines and Microglia [0.03%]
神经元的免疫调节作用：从快速神经活动到长期调控细胞因子和小胶质细胞
Levi B Wood,Annabelle C Singer
Levi B Wood
Regulation of the brain's neuroimmune system is central to development, normal function, and disease. Neuronal communication to microglia, the primary immune cells of the brain, is well known to involve purinergic signaling mediated via ATP...
Sergey D Stavisky
Sergey D Stavisky
People who have lost the ability to speak due to neurological injuries would greatly benefit from assistive technology that provides a fast, intuitive, and naturalistic means of communication. This need can be met with brain-computer interf...
Kevin A Janes,Matthew J Lazzara
Kevin A Janes
Questions in cancer have engaged systems biologists for decades. During that time, the quantity of molecular data has exploded, but the need for abstractions, formal models, and simplifying insights has remained the same. This review brings...