Timothy P Padera,Eelco F J Meijer,Lance L Munn
Timothy P Padera
Advances in our understanding of the structure and function of the lymphatic system have made it possible to identify its role in a variety of disease processes. Because it is involved not only in fluid homeostasis but also in immune cell t...
Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery [0.03%]
新一代药物和疫苗载体的理性设计
Balaji Narasimhan,Jonathan T Goodman,Julia E Vela Ramirez
Balaji Narasimhan
Pattern recognition receptors on innate immune cells play an important role in guiding how cells interact with the rest of the organism and in determining the direction of the downstream immune response. Recent advances have elucidated the ...
Tissue Patterning: Translating Design Principles from In Vivo to In Vitro [0.03%]
组织图案设计：从体内到体外的原理转换
Alison P McGuigan,Sahar Javaherian
Alison P McGuigan
Recapitulating the architecture of native tissue remains a significant challenge, impeding the progress of engineering tissues. Imposing appropriate organization is especially challenging in tissues that contain multiple cellular components...
Hamiltonian Systems and Optimal Control in Computational Anatomy: 100 Years Since D'Arcy Thompson [0.03%]
计算解剖学中的哈密顿系统和最优控制：D'Arcy Thompson 过后的 100 年
Michael I Miller,Alain Trouvé,Laurent Younes
Michael I Miller
The Computational Anatomy project is the morphome-scale study of shape and form, which we model as an orbit under diffeomorphic group action. Metric comparison calculates the geodesic length of the diffeomorphic flow connecting one form to ...
Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems [0.03%]
正电子发射断层扫描：临床和前临床 imaging系统技术进步的现状挑战与机遇
Juan José Vaquero,Paul Kinahan
Juan José Vaquero
Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give P...
V Y Wang,P M F Nielsen,M P Nash
V Y Wang
Personalized biophysical modeling of the heart is a useful approach for noninvasively analyzing and predicting in vivo cardiac mechanics. Three main developments support this style of analysis: state-of-the-art cardiac imaging technologies,...
Biological Soft Robotics [0.03%]
软体机器人学
Adam W Feinberg
Adam W Feinberg
In nature, nanometer-scale molecular motors are used to generate force within cells for diverse processes from transcription and transport to muscle contraction. This adaptability and scalability across wide temporal, spatial, and force reg...
Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease [0.03%]
工程与生物学协同研究骨骼肌损伤和疾病的治疗与建模
Nenad Bursac,Mark Juhas,Thomas A Rando
Nenad Bursac
Although skeletal muscle is one of the most regenerative organs in our body, various genetic defects, alterations in extrinsic signaling, or substantial tissue damage can impair muscle function and the capacity for self-repair. The diversit...
The Mechanobiology of Aging [0.03%]
衰老的机械生物学
Jude M Phillip,Ivie Aifuwa,Jeremy Walston et al.
Jude M Phillip et al.
Aging is a complex, multifaceted process that induces a myriad of physiological changes over an extended period of time. Aging is accompanied by major biochemical and biomechanical changes at macroscopic and microscopic length scales that a...
Alphonsus H C Ng,Bingyu Betty Li,M Dean Chamberlain et al.
Alphonsus H C Ng et al.
Digital microfluidics (DMF) is a droplet-based liquid-handling technology that has recently become popular for cell culture and analysis. In DMF, picoliter- to microliter-sized droplets are manipulated on a planar surface using electric fie...