Sabrina Jahn,Jasmine Seror,Jacob Klein
Sabrina Jahn
The major synovial joints such as hips and knees are uniquely efficient tribological systems, able to articulate over a wide range of shear rates with a friction coefficient between the sliding cartilage surfaces as low as 0.001 up to press...
Colin D Paul,Wei-Chien Hung,Denis Wirtz et al.
Colin D Paul et al.
Cells in the body are physically confined by neighboring cells, tissues, and the extracellular matrix. Although physical confinement modulates intracellular signaling and the underlying mechanisms of cell migration, it is difficult to study...
Marco Viceconti,Peter Hunter
Marco Viceconti
Biomedical research and clinical practice are struggling to cope with the growing complexity that the progress of health care involves. The most challenging diseases, those with the largest socioeconomic impact (cardiovascular conditions; m...
Aydogan Ozcan,Euan McLeod
Aydogan Ozcan
High-resolution optical microscopy has traditionally relied on high-magnification and high-numerical aperture objective lenses. In contrast, lensless microscopy can provide high-resolution images without the use of any focusing lenses, offe...
Design of Catalytic Peptides and Proteins Through Rational and Combinatorial Approaches [0.03%]
理性及组合方法的设计催化肽和蛋白质
Yoshiaki Maeda,Olga V Makhlynets,Hiroshi Matsui et al.
Yoshiaki Maeda et al.
This review focuses on recent progress in noncomputational methods to introduce catalytic function into proteins, peptides, and peptide assemblies. We discuss various approaches to creating catalytic activity and classification of noncomput...
Xunrong Luo,Stephen D Miller,Lonnie D Shea
Xunrong Luo
The undesired destruction of healthy cells, either endogenous or transplanted, by the immune system results in the loss of tissue function or limits strategies to restore tissue function. Current therapies typically involve nonspecific immu...
Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy [0.03%]
淋巴结淋巴输送的免疫和免疫治疗含义
Susan N Thomas,Nathan A Rohner,Erin E Edwards
Susan N Thomas
Adaptive immune response consists of many highly regulated, multistep cascades that protect against infection while preserving the health of autologous tissue. The proper initiation, maintenance, and resolution of such responses require the...
Innovative Tools and Technology for Analysis of Single Cells and Cell-Cell Interaction [0.03%]
单细胞及细胞互作分析的创新工具与技术
Tania Konry,Saheli Sarkar,Pooja Sabhachandani et al.
Tania Konry et al.
Heterogeneity in single-cell responses and intercellular interactions results from complex regulation of cell-intrinsic and environmental factors. Single-cell analysis allows not only detection of individual cellular characteristics but als...
Microfluidics for High-Throughput Quantitative Studies of Early Development [0.03%]
微流体技术在早期胚胎发育高通量定量研究中的应用
Thomas J Levario,Bomyi Lim,Stanislav Y Shvartsman et al.
Thomas J Levario et al.
Developmental biology has traditionally relied on qualitative analyses; recently, however, as in other fields of biology, researchers have become increasingly interested in acquiring quantitative knowledge about embryogenesis. Advances in f...
Hang Yin,Aaron D Flynn
Hang Yin
The majority of therapeutics target membrane proteins, accessible on the surface of cells, to alter cellular signaling. Cells use membrane proteins to transduce signals into cells, transport ions and molecules, bind cells to a surface or su...