Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications [0.03%]
合成生物学在工程益生菌和人体微生物群成员以用于生物医学应用方面的研究进展
Josef R Bober,Chase L Beisel,Nikhil U Nair
Josef R Bober
An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights ha...
Advanced Endoscopic Navigation: Surgical Big Data, Methodology, and Applications [0.03%]
先进的内镜导航：手术大数据、方法学和应用
Xiongbiao Luo,Kensaku Mori,Terry M Peters
Xiongbiao Luo
Interventional endoscopy (e.g., bronchoscopy, colonoscopy, laparoscopy, cystoscopy) is a widely performed procedure that involves either diagnosis of suspicious lesions or guidance for minimally invasive surgery in a variety of organs withi...
Facet Joints of the Spine: Structure-Function Relationships, Problems and Treatments, and the Potential for Regeneration [0.03%]
脊柱小关节的结构与功能关系、问题和治疗及潜在再生能力
Siobhan A O&#x;Leary,Nikolaos K Paschos,Jarrett M Link et al.
Siobhan A O&#x;Leary et al.
The zygapophysial joint, a diarthrodial joint commonly referred to as the facet joint, plays a pivotal role in back pain, a condition that has been a leading cause of global disability since 1990. Along with the intervertebral disc, the fac...
Electrophysiological Source Imaging: A Noninvasive Window to Brain Dynamics [0.03%]
脑电生理源成像：窥探大脑动力学的无创窗口
Bin He,Abbas Sohrabpour,Emery Brown et al.
Bin He et al.
Brain activity and connectivity are distributed in the three-dimensional space and evolve in time. It is important to image brain dynamics with high spatial and temporal resolution. Electroencephalography (EEG) and magnetoencephalography (M...
Michael R McDevitt,George Sgouros,Stavroula Sofou
Michael R McDevitt
α-Particle irradiation of cancerous tissue is increasingly recognized as a potent therapeutic option. We briefly review the physics, radiobiology, and dosimetry of α-particle emitters, as well as the distinguishing features that make them...
Jamie Brenner,Jang Hwan Cho,Nicole M L Wong et al.
Jamie Brenner et al.
Cellular immunotherapy holds great promise for the treatment of human disease. Clinical evidence suggests that T cell immunotherapies have the potential to combat cancers that evade traditional immunotherapy. Despite promising results, adve...
Pamela K Kreeger,Laura E Strong,Kristyn S Masters
Pamela K Kreeger
In their native environment, cells are immersed in a complex milieu of biochemical and biophysical cues. These cues may include growth factors, the extracellular matrix, cell-cell contacts, stiffness, and topography, and they are responsibl...
Engineering Hydrogel Microenvironments to Recapitulate the Stem Cell Niche [0.03%]
工程构建凝胶微环境以再现干细胞生态位
Christopher M Madl,Sarah C Heilshorn
Christopher M Madl
Stem cells are a powerful resource for many applications including regenerative medicine, patient-specific disease modeling, and toxicology screening. However, eliciting the desired behavior from stem cells, such as expansion in a naïve st...
Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form [0.03%]
内源生物电信号网络：利用电压梯度控制生长和形态形成
Michael Levin,Giovanni Pezzulo,Joshua M Finkelstein
Michael Levin
Living systems exhibit remarkable abilities to self-assemble, regenerate, and remodel complex shapes. How cellular networks construct and repair specific anatomical outcomes is an open question at the heart of the next-generation science of...
Vineet Gupta,Yusuf Khan,Cory J Berkland et al.
Vineet Gupta et al.
Microspheres have long been used in drug delivery applications because of their controlled release capabilities. They have increasingly served as the fundamental building block for fabricating scaffolds for regenerative engineering because ...