The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease [0.03%]
驱动力：细胞功能、命运和疾病中的核机械转导
Melanie Maurer,Jan Lammerding
Melanie Maurer
Cellular behavior is continuously affected by microenvironmental forces through the process of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical responses. Mounting evidence suggests that the nucleus itse...
Frontiers in Cryo Electron Microscopy of Complex Macromolecular Assemblies [0.03%]
复杂巨分子复合物的冷冻电镜技术进展
Jana Ognjenović,Reinhard Grisshammer,Sriram Subramaniam
Jana Ognjenović
In recent years, cryo electron microscopy (cryo-EM) technology has been transformed with the development of better instrumentation, direct electron detectors, improved methods for specimen preparation, and improved software for data analysi...
Eun Kwang Lee,Min Ku Kim,Chi Hwan Lee
Eun Kwang Lee
Miniaturization of electronic components and advances in flexible and stretchable materials have stimulated the development of wearable health care systems that can reflect and monitor personal health status by health care professionals. Ne...
Yanxiang Deng,Amanda Finck,Rong Fan
Yanxiang Deng
Single-cell omics studies provide unique information regarding cellular heterogeneity at various levels of the molecular biology central dogma. This knowledge facilitates a deeper understanding of how underlying molecular and architectural ...
Barry A Badeau,Cole A DeForest
Barry A Badeau
Stimuli-responsive materials undergo triggered changes when presented with specific environmental cues. These dynamic systems can leverage biological signals found locally within the body as well as exogenous cues administered with spatiote...
Frontiers of Medical Robotics: From Concept to Systems to Clinical Translation [0.03%]
医疗机器人学：从理念到系统再到临床应用的前沿研究
Jocelyne Troccaz,Giulio Dagnino,Guang-Zhong Yang
Jocelyne Troccaz
Medical robotics is poised to transform all aspects of medicine-from surgical intervention to targeted therapy, rehabilitation, and hospital automation. A key area is the development of robots for minimally invasive interventions. This revi...
Hydrogel-Based Strategies to Advance Therapies for Chronic Skin Wounds [0.03%]
基于水凝胶的策略以推进慢性皮肤伤口治疗的发展
Lucília P da Silva,Rui L Reis,Vitor M Correlo et al.
Lucília P da Silva et al.
Chronic skin wounds are the leading cause of nontraumatic foot amputations worldwide and present a significant risk of morbidity and mortality due to the lack of efficient therapies. The intrinsic characteristics of hydrogels allow them to ...
Eleonora Dal Sasso,Andrea Bagno,Silvia T G Scuri et al.
Eleonora Dal Sasso et al.
There are limited therapeutic options for final treatment of end-stage heart failure. Among them, implantation of a total artificial heart (TAH) is an acceptable strategy when suitable donors are not available. TAH development began in the ...
Prevention of Opioid Abuse and Treatment of Opioid Addiction: Current Status and Future Possibilities [0.03%]
阿片类药物滥用的预防和阿片类药物依赖的治疗：现状与未来展望
Kinam Park,Andrew Otte
Kinam Park
Prescription opioid medications have seen a dramatic rise in misuse and abuse, leading regulators and scientists to develop policies and abuse-deterrent technologies to combat the current opioid epidemic. These abuse-deterrent formulations ...
Exploring Dynamics and Structure of Biomolecules, Cryoprotectants, and Water Using Molecular Dynamics Simulations: Implications for Biostabilization and Biopreservation [0.03%]
基于分子动力学模拟探讨生物大分子、保护剂及水的结构和构效关系：对生物稳定化技术的意义
Lindong Weng,Shannon L Stott,Mehmet Toner
Lindong Weng
Successful stabilization and preservation of biological materials often utilize low temperatures and dehydration to arrest molecular motion. Cryoprotectants are routinely employed to help the biological entities survive the physicochemical ...